Bromelain
10 benefits mapped to clinical evidence across supplements.
Dose per serving from products
2,382 products in our catalogue print how much Bromelain a serving holds.
Most common: 10 mg to 25 mg, 29% of 2,382 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 118 |
| 5 mg to 10 mg | 127 |
| 10 mg to 25 mg | 691 |
| 25 mg to 50 mg | 326 |
| 50 mg to 100 mg | 356 |
| 100 mg to 250 mg | 400 |
| 250 mg to 500 mg | 265 |
| over 500 mg | 99 |
Dose per serving from research
15 study groups in 12 studies say how much Bromelain participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg, 47% of 15 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 1 |
| 100 mg to 250 mg | 7 |
| 250 mg to 500 mg | 4 |
| 500 mg to 1 g | 2 |
| 1 g to 2.5 g | 0 |
| over 2.5 g | 1 |
Benefit Evidence
Research sources
Pain relief (15)
- Naturopathic treatment of rotator cuff tendinitis among Canadian postal workers: a randomized controlled trial
PubMed ID: 19644905
Naturopathic care package that included Phlogenzym produced greater shoulder pain reduction versus exercise alone (multimodal intervention).
- Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 24589242
Perioperative oral bromelain reduced pain and improved QoL after third‑molar surgery, similar to diclofenac.
- Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study
PubMed ID: 25019111
RCT after third molar surgery: bromelain significantly reduced postoperative pain vs control.
- Perioperative Bromelain Therapy after Wisdom Teeth Extraction - A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study
PubMed ID: 27601419
Dose‑finding study showed symptom benefits with pooled bromelain vs placebo including pain trend.
- Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes
PubMed ID: 32122870
Proteolytic enzyme add‑on reduced VAS pain in lumbar OA (moderate evidence, confounded by concomitant therapy).
- An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study
PubMed ID: 38542694
Pilot RCT: oral bromelain/pineapple extract markedly reduced pain and halved rescue ibuprofen use after wisdom‑tooth removal.
- Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study
PubMed ID: 40534304
Pediatric orchiepididymitis trial: bromelain extract reduced pain scores and NSAID need vs placebo.
- Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial
PubMed ID: 40260785
Triple‑blind RCT: oral bromelain (± turmeric) reduced early orthodontic pain more than ibuprofen.
- Systemic enzyme therapy for postoperative inflammation and wound healing after orthopedic surgery: a randomized, placebo and active controlled clinical study
PubMed ID: 41038853
Large, consistent reductions in post‑operative pain (VAS) versus placebo indicate strong analgesic/anti‑inflammatory effect in surgical patients.
- Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study
PubMed ID: 23043451
Rotator cuff repair trial: multi‑ingredient supplement including bromelain produced significant pain reduction.
- A Nutraceutical Combination of Bromelain and Boswellia Serrata Casperome® in Siben®: Effects on the Postoperative Course of Inguinal Hernioplasty with Mesh at One Year Follow up. A Randomized Multicentric Study
PubMed ID: 38918956
Postoperative hernia trial: bromelain+Boswellia reduced postoperative pain and improved QoL/recovery.
- Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial
PubMed ID: 11584936
Oral enzyme therapy showed at least comparable analgesic effects to diclofenac in knee osteoarthrosis.
- Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults
PubMed ID: 12587686
Open‑label bromelain reduced knee pain vs baseline in mild cases (no placebo).
- Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study
PubMed ID: 15278753
Oral enzyme combo produced pain/function improvements in knee OA comparable to diclofenac.
- Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs
PubMed ID: 16539815
Phlogenzym provided pain, stiffness and function improvements in hip OA similar to diclofenac.
Swelling relief (10)
- Systemic enzyme therapy for postoperative inflammation and wound healing after orthopedic surgery: a randomized, placebo and active controlled clinical study
PubMed ID: 41038853
Orthopedic post‑operative patients experienced marked reductions in swelling/inflammation and biomarkers, directly supporting control of post‑injury/post‑surgical swelling.
- Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
PubMed ID: 39929877
Large RCT after breast surgery: bromelain+Boswellia markedly lowered early postoperative swelling and seroma rates.
- A Nutraceutical Combination of Bromelain and Boswellia Serrata Casperome® in Siben®: Effects on the Postoperative Course of Inguinal Hernioplasty with Mesh at One Year Follow up. A Randomized Multicentric Study
PubMed ID: 38918956
Post‑hernia surgery trial: combined product reduced postoperative swelling and aided faster recovery.
- Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study
PubMed ID: 15278753
Oral enzyme combo reduced joint tenderness/swelling in knee OA similar to diclofenac.
- Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs
PubMed ID: 16539815
Phlogenzym (contains bromelain) gave meaningful OA symptom improvements including measures reflecting swelling.
- A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling
PubMed ID: 23566694
Systemic enzyme therapy significantly reduced postoperative facial edema after orthognathic surgery.
- Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study
PubMed ID: 25019111
RCT after impacted third molar surgery found significant reductions in edema vs control.
- Perioperative Bromelain Therapy after Wisdom Teeth Extraction - A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study
PubMed ID: 27601419
Perioperative dosing reduced postoperative facial swelling (pooled vs placebo) after wisdom‑tooth extraction.
- An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study
PubMed ID: 38542694
Oral bromelain/pineapple extract reduced swelling after wisdom‑tooth removal and improved QoL and analgesic use.
- Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study
PubMed ID: 40534304
Oral bromelain accelerated resolution of edema on ultrasound in pediatric orchiepididymitis.
Tissue repair (8)
- Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study
PubMed ID: 23043451
After rotator cuff repair a multi‑ingredient supplement including bromelain reduced pain and showed modest imaging benefit, consistent with faster recovery (confounded).
- Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
PubMed ID: 39929877
Strong RCT evidence that bromelain+Boswellia greatly reduced oedema/seroma after breast conserving surgery and improved early recovery metrics.
- A Nutraceutical Combination of Bromelain and Boswellia Serrata Casperome® in Siben®: Effects on the Postoperative Course of Inguinal Hernioplasty with Mesh at One Year Follow up. A Randomized Multicentric Study
PubMed ID: 38918956
Multicentre randomized study: short postoperative bromelain+Boswellia reduced pain and sped return to activities after hernia repair.
- Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 24589242
Perioperative use improved pain and QoL after extraction—supports faster functional recovery.
- An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study
PubMed ID: 38542694
Oral bromelain/pineapple extract reduced pain and swelling and halved ibuprofen use post‑extraction, indicating faster symptomatic recovery.
- Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns
PubMed ID: 40117996
Pediatric RCT replicated rapid eschar removal and dramatic reduction in surgical excision vs standard care—strong procedural recovery benefit.
- The Effectiveness of Bromelain on Oedema, Subconjunctival Haemorrhage, and Ecchymosis After Rhinoplasty: A Randomised, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39904804
Rhinoplasty study: bromelain reduced bruising/subconjunctival haemorrhage at day 7—facilitates postoperative cosmetic recovery though oedema unchanged.
- Systemic enzyme therapy for postoperative inflammation and wound healing after orthopedic surgery: a randomized, placebo and active controlled clinical study
PubMed ID: 41038853
In orthopedic surgical patients, the enzyme product with bromelain produced large reductions in pain, swelling and inflammatory markers versus placebo, indicating accelerated clinical recovery after procedures.
Joint comfort (7)
- Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial
PubMed ID: 40803821
Proof‑of‑mechanism crossover in knee OA showed small KOOS symptom/pain improvements and favorable biomarker changes (↑IL‑10, ↓uCTX‑II).
- Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial
PubMed ID: 11584936
Oral enzyme therapy (combination including proteases) at least as effective as diclofenac for knee osteoarthrosis; product not pure bromelain.
- Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults
PubMed ID: 12587686
Open‑label dose-ranging bromelain reduced mild recent knee pain vs baseline (no placebo control).
- Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study
PubMed ID: 15278753
RCT showing oral enzyme combination (includes bromelain) non-inferior to diclofenac with meaningful improvement in knee OA indices.
- Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs
PubMed ID: 16539815
Phlogenzym (contains bromelain) produced clinically similar improvements to diclofenac in hip OA.
- Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes
PubMed ID: 32122870
Proteolytic enzymes including bromelain added to standard therapy reduced pain and disability in lumbar OA (moderate evidence; confounded by concomitant meds).
- Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis
PubMed ID: 27470088
Randomized 16‑week trial showed symptomatic improvement (WOMAC) in knee osteoarthritis vs baseline.
Skin repair (6)
- Bromelain-based debridement versus collagenase ointment debridement of venous leg ulcers: post hoc analysis of the ChronEx trial
PubMed ID: 40368392
Bromelain topical debridement achieved much higher complete debridement and granulation rates vs collagenase in venous leg ulcers.
- Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study
PubMed ID: 23043451
After rotator cuff repair, multi‑ingredient supplement including bromelain reduced pain and improved MRI repair integrity, suggesting modest healing support (attribution uncertain).
- Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
PubMed ID: 39929877
Post‑breast surgery RCT: bromelain+Boswellia markedly reduced edema/seroma—supports faster recovery of surgical wounds.
- A Nutraceutical Combination of Bromelain and Boswellia Serrata Casperome® in Siben®: Effects on the Postoperative Course of Inguinal Hernioplasty with Mesh at One Year Follow up. A Randomized Multicentric Study
PubMed ID: 38918956
Post‑hernia surgery study: bromelain+Boswellia reduced pain and improved return to activities, consistent with faster postoperative recovery.
- Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial
PubMed ID: 34231281
Topical bromelain (EscharEx) increased complete debridement incidence in chronic leg ulcers versus vehicle (improves wound bed preparation).
- Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns
PubMed ID: 40117996
Pediatric multicenter RCT: bromelain‑based debridement removed eschar much faster and avoided most surgical excision vs standard care.
Oral health (4)
- Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study
PubMed ID: 25019111
Clear RCT evidence that bromelain after impacted third‑molar surgery reduced pain, swelling and erythema—improves oral postoperative comfort.
- Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 24589242
Perioperative bromelain reduced pain and improved QoL after third‑molar surgery though swelling effect less consistent.
- Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple-Blind Randomized Clinical Trial
PubMed ID: 40260785
Triple‑blind RCT: bromelain (with/without turmeric) reduced early orthodontic separator pain more than ibuprofen—direct oral comfort benefit.
- Perioperative Bromelain Therapy after Wisdom Teeth Extraction - A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study
PubMed ID: 27601419
Dose‑finding study showed pooled bromelain improved postoperative swelling and some symptom measures after tooth extraction.
Immune support (2)
- Efficacy and safety of phlogenzym--a protease formulation, in sepsis in children
PubMed ID: 12164403
Phlogenzym (contains bromelain) as adjunct in children with sepsis modestly sped fever resolution and restarting feeds; clinical immune/recovery signal.
- Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study
PubMed ID: 41315628
Bromelain supplementation reduced disease activity in ulcerative colitis (immune‑mediated GI disease), consistent with immunomodulation.
Blood circulation (2)
- Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study
PubMed ID: 40534304
Pediatric orchiepididymitis trial: bromelain extract accelerated reduction of hypervascularity on ultrasound indicating improved resolution of inflammatory hyperemia.
- The Effectiveness of Bromelain on Oedema, Subconjunctival Haemorrhage, and Ecchymosis After Rhinoplasty: A Randomised, Double-Blind, Placebo-Controlled Trial
PubMed ID: 39904804
Randomized double‑blind rhinoplasty study showed significant reductions in ecchymosis and subconjunctival haemorrhage on day 7.
Respiratory comfort (1)
- Efficacy and safety of Atusin(®) CAP in the treatment of acute uncomplicated bronchitis in the primary care setting: a multi-center, randomized, double-blind, placebo-controlled study (AABA)
PubMed ID: 41034950
Combination product including bromelain produced faster reduction in bronchitis severity, cough frequency and cough severity versus placebo (direct respiratory symptom benefit, but multi‑ingredient product).
Digestive support (1)
- Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study
PubMed ID: 41315628
Eight‑week bromelain supplementation reduced ulcerative colitis activity (GI disease benefit), though effect is on inflammation/disease activity rather than normal digestion.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Bromelain
Search all5467 products whose verified label declares Bromelain — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.