Black Seed Oil
15 benefits mapped to clinical evidence across supplements.
Dose per serving from products
482 products in our catalogue print how much Black Seed Oil a serving holds.
Most common: 100 mg to 250 mg, 35% of 482 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 10 |
| 10 mg to 25 mg | 45 |
| 25 mg to 50 mg | 87 |
| 50 mg to 100 mg | 30 |
| 100 mg to 250 mg | 171 |
| 250 mg to 500 mg | 81 |
| 500 mg to 1 g | 41 |
| over 1 g | 17 |
Dose per serving from research
16 study groups in 16 studies say how much Black Seed Oil participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 44% of 16 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg to 500 mg | 2 |
| 500 mg to 1 g | 7 |
| 1 g to 2.5 g | 4 |
| 2.5 g to 5 g | 3 |
Benefit Evidence
Pain/function improved
-34% pain, -28% function
Massage/reflexology eased pain
Pain/function improved
-34% pain, -28% function
Massage/reflexology eased pain
Research sources
Metabolism (10)
- Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus
PubMed ID: 32510754
T2DM RCT improved fasting glucose, lipids and inflammatory markers over 8 weeks.
- A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients
PubMed ID: 33957004
Hypertension study lowered FBS and LDL in addition to BP and oxidative markers.
- Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 34142392
T2D double-blind RCT decreased HbA1c, FBS, TC and anthropometrics.
- Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 33851461
CAD patients had reductions in weight, waist, BP and modest FBS change.
- Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin
PubMed ID: 34006388
Six-month obese prediabetic trial showed weight, glycemic and anti-inflammatory effects similar to metformin for many measures.
- Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial
PubMed ID: 27678438
NSO + calorie restriction markedly lowered TNF‑α and hs‑CRP — improved inflammatory milieu linked to metabolic health.
- The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 33370571
Overweight/obese women lost weight, BMI and body fat over 8 weeks, with appetite reduction.
- The effect of Nigella sativa supplementation on cardiovascular risk factors in obese and overweight women: a crossover, double-blind, placebo-controlled randomized clinical trial
PubMed ID: 32876804
Improved lipid profile and reduced SBP in overweight women, relevant to metabolic syndrome.
- Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial
PubMed ID: 30639231
NAFLD RCT: NS seed oil reduced hepatic steatosis, ALT and improved triglycerides — substantial metabolic relevance.
- Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial
PubMed ID: 26029855
DBPC trial: NSO + low‑calorie diet produced larger weight, waist and triglyceride reductions vs diet alone — strong metabolic benefits.
Heart health (10)
- Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial
PubMed ID: 35871718
Reduced sVCAM-1, sICAM-1 and MDA in CAD patients, indicating improved endothelial/oxidative profile.
- Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 23436437
Randomized DBPC trial: 5 mL/day Nigella sativa oil for 8 weeks significantly lowered systolic and diastolic blood pressure.
- The effect of Nigella sativa supplementation on cardiovascular risk factors in obese and overweight women: a crossover, double-blind, placebo-controlled randomized clinical trial
PubMed ID: 32876804
Raised HDL, lowered LDL and reduced systolic BP in overweight/obese women (crossover RCT).
- Protective role of black seed oil in doxorubicin-induced cardiac toxicity in children with acute lymphoblastic leukemia
PubMed ID: 31964219
In children on doxorubicin, NSO reduced decline in LV systolic function, suggesting cardioprotection.
- Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus
PubMed ID: 32510754
T2DM trial improved lipids and inflammatory markers relevant to cardiovascular risk.
- A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients
PubMed ID: 33957004
Hypertensive trial showed SBP reduction, LDL decrease and improved oxidative markers.
- Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 34142392
T2D trial lowered HbA1c, TC, TG and blood pressure, supportive of heart health.
- Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 33851461
Coronary artery disease patients saw reductions in weight, BP and fasting glucose; cardio-relevant benefits.
- The effect of Nigella sativa oil on vascular dysfunction assessed by flow-mediated dilation and vascular-related biomarkers in subject with cardiovascular disease risk factors: A randomized controlled trial
PubMed ID: 35412685
Improved endothelial function (FMD) and increased plasma NOx versus placebo.
- Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study
PubMed ID: 40048139
Pediatric T1D trial improved LV strain and reduced troponin and LDL over 3 months.
Inflammation (8)
- Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin
PubMed ID: 34006388
Six-month trial in prediabetics reduced TNF-α and systemic inflammation comparably to metformin.
- The Effect of Foot Reflexology and Knee Massage With Black Cumin Seed Oil on Knee Osteoarthritis Symptoms
PubMed ID: 39642267
OA trial combining manual therapy and oil showed reduced pain/fatigue—may reflect anti-inflammatory effects though multi-component.
- Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial
PubMed ID: 27678438
DBPC RCT: NSO + calorie restriction reduced TNF‑α by ~41% and hs‑CRP by ~55% vs smaller declines with placebo — strong anti‑inflammatory evidence.
- Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of Cyclic Mastalgia: A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial
PubMed ID: 26584456
Topical NSO reduced cyclic breast pain similar to diclofenac — suggests anti‑inflammatory/analgesic topical action.
- Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 36150238
Knee OA RCT: large pain and function improvements consistent with anti‑inflammatory/analgesic effects of NSO.
- Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus
PubMed ID: 32510754
T2DM RCT decreased hs-CRP and other inflammatory/oxidative markers.
- A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women
PubMed ID: 38178093
Crossover RCT showed robust reductions in IL-1β, IL-6 and downregulated PBMC inflammatory gene expression.
- Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial
PubMed ID: 35871718
Significant reductions in endothelial adhesion molecules (sVCAM-1, sICAM-1) and MDA in CAD patients.
Weight management (6)
- Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 33851461
Coronary artery disease patients lost weight, BMI and waist circumference in an 8-week RCT.
- Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 34142392
T2D trial reported decreases in BMI and waist circumference alongside metabolic improvements.
- The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 33370571
Crossover double-blind RCT in overweight/obese women showed significant decreases in weight, BMI and body fat over 8 weeks.
- Oxidative Stress Responses to Nigella sativa Oil Concurrent with a Low-Calorie Diet in Obese Women: A Randomized, Double-Blind Controlled Clinical Trial
PubMed ID: 26179113
Randomized trial: NSO with calorie restriction reduced weight substantially vs placebo.
- Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial
PubMed ID: 26029855
DBPC RCT: NSO + low‑calorie diet led to significantly greater weight and waist reductions vs diet alone.
- Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin
PubMed ID: 34006388
Six-month obese prediabetic trial demonstrated weight improvements comparable to metformin.
Respiratory comfort (5)
- Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
PubMed ID: 34407441
Mild COVID trial shortened respiratory symptom durations and increased recovery rate.
- Herbal treatment of allergic rhinitis: the use of Nigella sativa
PubMed ID: 20947211
Randomized DB trial: NSO reduced nasal allergy symptoms over 2 weeks — good evidence for nasal/upper airway symptom relief.
- Topical Nigella Sativa for nasal symptoms in elderly
PubMed ID: 24398317
Crossover RCT in older adults: intranasal NSO relieved nasal dryness/obstruction/crusting vs saline — strong topical nasal benefit.
- Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 28093815
DBPC trial: oral NSO improved asthma control scores and reduced blood eosinophils vs placebo — strong respiratory benefit.
- A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy
PubMed ID: 39121267
Allergy trial reduced nasal symptom scores and ocular symptoms over 15 days.
Allergy relief (4)
- Herbal treatment of allergic rhinitis: the use of Nigella sativa
PubMed ID: 20947211
Randomized DB trial: NSO reduced nasal allergy symptoms over 2 weeks — strong direct evidence for allergic rhinitis.
- Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 28093815
Asthma RCT: improved asthma control and eosinophil reductions — supports allergy/airway inflammation relief.
- A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy
PubMed ID: 39121267
15-day standardized NSO RCT substantially reduced nasal and ocular allergy scores and lowered IgE vs placebo.
- Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases
PubMed ID: 14669258
Pooled small clinical studies: oral NSO improved self‑reported allergy symptoms across four studies.
Antioxidant (4)
- Oxidative Stress Responses to Nigella sativa Oil Concurrent with a Low-Calorie Diet in Obese Women: A Randomized, Double-Blind Controlled Clinical Trial
PubMed ID: 26179113
Randomized trial: NSO + calorie restriction raised RBC SOD substantially — evidence for antioxidant enzyme upregulation.
- Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial
PubMed ID: 35871718
MDA decreased significantly in CAD patients.
- A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients
PubMed ID: 33957004
Hypertension trial reduced MDA and increased glutathione-related markers.
- Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus
PubMed ID: 32510754
T2DM RCT decreased MDA and improved oxidative/inflammatory markers.
Joint comfort (3)
- Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial
PubMed ID: 36150238
Well‑conducted RCT: oral Nigella sativa oil substantially reduced knee osteoarthritis pain and improved function vs placebo.
- Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric individuals
PubMed ID: 29705470
Topical black cumin oil reduced self-reported knee pain in older adults in a randomized trial.
- The Effect of Foot Reflexology and Knee Massage With Black Cumin Seed Oil on Knee Osteoarthritis Symptoms
PubMed ID: 39642267
Massage/reflexology with black cumin oil reduced knee osteoarthritis pain and fatigue; effect multi-component but notable.
Immune support (3)
- A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women
PubMed ID: 38178093
Downregulation of proinflammatory cytokine gene expression and reduced serum IL-1β/IL-6 suggests immune modulation.
- Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
PubMed ID: 34407441
Large RCT in mild COVID-19 increased clinical recovery rate and shortened symptom durations.
- A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy
PubMed ID: 39121267
Randomized trial reduced nasal/ocular allergy symptoms and serum IgE over 15 days.
Liver support (2)
- Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase and lipid levels in non-alcoholic fatty liver disease: A randomized, double-blind and placebo-controlled clinical trial
PubMed ID: 30639231
DBPC NAFLD RCT: standardized NS seed oil improved hepatic steatosis grade and lowered ALT and triglycerides vs placebo.
- Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia
PubMed ID: 25809628
Controlled study in children with ALL: NSO reduced methotrexate‑related liver enzyme rises and improved clinical outcomes.
Oral health (2)
- A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial
PubMed ID: 35685605
Intra-socket application of black seed yielded faster pain relief and healing vs standard dressing or saline in randomized study.
- Comparative evaluation of the efficacy of Nigella sativa (75% v/v) cream and clobetasol propionate (0.05% w/w) gel in oral lichen planus-a double-blinded randomized control trial
PubMed ID: 36547822
Topical black seed cream greatly reduced pain and lesion size in oral lichen planus, comparable to steroid gel.
Skin health (2)
- Comparative evaluation of the efficacy of Nigella sativa (75% v/v) cream and clobetasol propionate (0.05% w/w) gel in oral lichen planus-a double-blinded randomized control trial
PubMed ID: 36547822
Topical NS cream substantially reduced lesion size and burning in oral lichen planus, comparable to steroid.
- A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial
PubMed ID: 35685605
Intra-socket application accelerated pain relief and healing in dry socket vs controls.
Skin repair (2)
- A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial
PubMed ID: 35685605
Black seed application in dry socket accelerated pain relief and mucosal healing versus controls.
- Comparative evaluation of the efficacy of Nigella sativa (75% v/v) cream and clobetasol propionate (0.05% w/w) gel in oral lichen planus-a double-blinded randomized control trial
PubMed ID: 36547822
Topical NS cream produced large reductions in lesion size in oral mucosal disease comparable to steroid.
Hormone balance (2)
- Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 24680621
DBPC RCT: oral Nigella sativa oil improved semen quality (count, motility, morphology) in infertile men suggesting endocrine/reproductive effects.
- A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese women
PubMed ID: 38178093
Marked reduction in serum and gene-expression leptin in overweight women indicates endocrine modulation.
Digestive support (1)
- Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial
PubMed ID: 26386381
Double‑blind RCT: Nigella sativa + honey improved dyspepsia symptoms and reduced H. pylori vs placebo.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Black Seed Oil
Search all681 products whose verified label declares Black Seed Oil — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.