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Piperine and Curcumin: study protocols

24 study groups took Piperine together with Curcumin. These are the doses the studies gave. They are not a recommendation.

Piperine: what the research found →

Dose per serving from research: Piperine

24 study groups in 22 studies say how much Piperine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mg to 5 mg, 38% of 24 study groups.

Daily doseStudy groups
2.5 mg to 5 mg
9
5 mg to 10 mg
8
10 mg to 25 mg
5
25 mg to 50 mg
1
over 50 mg
1

Dose per serving from research: Curcumin

23 study groups in 21 studies say how much Curcumin participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 39% of 23 study groups.

Daily doseStudy groups
250 mg or less
1
250 mg to 500 mg
9
500 mg to 1 g
8
1 g to 2.5 g
5

Commonly used together

2 of 24 study groups took Piperine and Curcumin with something else, but nothing that 3 or more different studies gave.

24 study groups

Study
The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
2022 · curcumin-piperine group · Adults aged 18–65 with RT-PCR-confirmed COVID-19 who were outpatients and did not have severe disease requiring hospitalization
10 mg1 g2 weeks23
Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients
2024 · Group III · Female patients with systemic lupus erythematosus (SLE); age not reported
15.8 g600 mg90 days15
Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial
2025 · curcumin plus piperine · Adults aged 18 years or older with mild to moderate inflammatory bowel disease
10 mg1 g12 weeks—
Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
2016 · curcuminoids + piperine combination · Adults with chronic pulmonary complications due to sulfur mustard exposure
15 mg1.5 g4 weeks45
Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study
2022 · CUR group · Single women aged 18–24 with moderate to severe premenstrual syndrome and dysmenorrhea
5 mg500 mg90 days38
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
2015 · curcuminoids · Adults with metabolic syndrome diagnosed according to NCEP-ATPIII criteria
10 mg1 g8 weeks59
Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus
2017 · curcuminoids versus placebo group · Patients with type 2 diabetes; age and sex not reported
10 mg1 g12 weeks50
Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial
2018 · curcuminoids · Adults aged 18–65 with type 2 diabetes mellitus
5 mg500 mg90 days50
Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial
2023 · Curcumin (CUR) group · Women aged 18–24 with moderate-to-severe premenstrual syndrome and dysmenorrhea
5 mg500 mg—38
The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
2023 · curcumin-piperine group · Adults aged 20–65 years with ischemic stroke in the rehabilitation phase, 3–6 months after the active stroke attack
5 mg500 mg12 weeks33
Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial
2025 · intervention group (curcumin-piperine) · Adults aged 20–75 with sepsis admitted to an ICU
10 mg1 g7 days33
Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial
2023 · curcumin + piperine · Patients with moderate-to-high non-alcoholic fatty liver disease diagnosed by liver sonography; age and sex not specified
5 mg500 mg12 weeks30
Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial
2016 · curcuminoids group · Adults with mild-to-moderate primary knee osteoarthritis
15 mg1.5 g6 weeks19
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
2013 · curcuminoid/piperine treatment · Healthy volunteers; age range and sex not specified
48 mg—2 days8
Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
2017 · curcuminoids · People with type 2 diabetes
10 mg1 g12 weeks—
Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial
2019 · curcuminoids plus piperine · Adults with ultrasound-determined nonalcoholic fatty liver disease; age and sex not specified
5 mg500 mg12 weeks—
Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial
2020 · curcuminoids group · Patients with non-alcoholic fatty liver disease (NAFLD); age and sex not reported
5 mg500 mg8 weeks—
Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double-blind placebo-controlled trial
2020 · Curcuminoids · Critically ill patients aged 18–65 years with traumatic brain injury
5 mg500 mg7 days—
Ubiquitin Proteasome System Activity is Suppressed by Curcumin following Exercise-Induced Muscle Damage in Human Skeletal Muscle
2021 · curcumin (CUR) group · Recreationally active males and females aged 18–30
20 mg2 g11 days—
Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial
2023 · curcumin-piperine · Patients with COVID-19 admitted to the intensive care unit; age and sex not specified
15 mg1.5 g7 days—
Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery
2024 · Group B · Adults who underwent coronary artery bypass graft surgery
5 mg500 mg5 days—
Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery
2024 · Group C · Adults who underwent coronary artery bypass graft surgery
10 mg1 g5 days—
Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery
2024 · Group D · Adults who underwent coronary artery bypass graft surgery
15 mg1.5 g5 days—
Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
2020 · Phytosomal curcumin · Adults aged 18–70 years with overweight (BMI 25–30 kg/m²) and suboptimal fasting plasma glucose (100–125 mg/dL)
8 mg200 mg8 weeks40
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