| Effects of Greenselect Phytosome® on weight maintenance after weight loss in obese women: a randomized placebo-controlled study 2016 · GSP group · Obese Caucasian women referred for a weight-loss lifestyle intervention; age range not stated | 30 mg | 90 days | 20 |
| Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study 2025 · CREP · Obese men and women aged 21–55 years with BMI 30–40 kg/m² | 10 mg | 90 days | 48 |
| A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study 2024 · ARE · Individuals with mild to moderate depression and anxiety | 5 mg | 90 days | 34 |
| A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy 2024 · NSO group · Adult men aged 22–44 with documented seasonal allergic rhinitis and at least two allergy symptoms | 5 mg | 15 days | 33 |
| A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study 2023 · ARE (Ashwagandha root extract) · Adults aged 21–54 years with mild-to-moderate stress and anxiety, without chronic disease | 5 mg | 60 days | 27 |
| The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial 2022 · curcumin-piperine group · Adults aged 18–65 with RT-PCR-confirmed COVID-19 who were outpatients and did not have severe disease requiring hospitalization | 10 mg | 2 weeks | 23 |
| Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients 2024 · Group III · Female patients with systemic lupus erythematosus (SLE); age not reported | 15.8 g | 90 days | 15 |
| Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity 2016 · resveratrol plus piperine · healthy young adults | 10 mg | 4 weeks | — |
| Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial 2025 · curcumin plus piperine · Adults aged 18 years or older with mild to moderate inflammatory bowel disease | 10 mg | 12 weeks | — |
| Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects 2013 · dietary supplement group · Healthy overweight men and women aged 25–45 years with BMI greater than 25 and less than 35 kg/m² | 6 mg | 8 weeks | 50 |
| The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial 2024 · Piperine group · Adults with grade 2 or 3 NAFLD and elevated ALT; men and women, mean age about 42 years | 5 mg | 12 weeks | 34 |
| Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study 2007 · Piperine · Healthy adult males aged 20–40 years | 20 mg | 7 days | 8 |
| Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial 2016 · curcuminoids + piperine combination · Adults with chronic pulmonary complications due to sulfur mustard exposure | 15 mg | 4 weeks | 45 |
| Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study 2022 · CUR group · Single women aged 18–24 with moderate to severe premenstrual syndrome and dysmenorrhea | 5 mg | 90 days | 38 |
| Comparative Pharmacokinetics of Curcuminoids from Water-Dispersible Turmeric Extract Against a Curcuminoids-Piperine Combination: An Open-Label, Randomized, Balanced, 2-Treatment, 2-Sequence, 2-Period Crossover Study 2024 · CPC reference product · healthy adult males; age range not reported | 15 mg | 1 day | 16 |
| Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis 2015 · curcuminoids · Adults with metabolic syndrome diagnosed according to NCEP-ATPIII criteria | 10 mg | 8 weeks | 59 |
| Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus 2017 · curcuminoids versus placebo group · Patients with type 2 diabetes; age and sex not reported | 10 mg | 12 weeks | 50 |
| Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial 2018 · curcuminoids · Adults aged 18–65 with type 2 diabetes mellitus | 5 mg | 90 days | 50 |
| Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial 2023 · Curcumin (CUR) group · Women aged 18–24 with moderate-to-severe premenstrual syndrome and dysmenorrhea | 5 mg | — | 38 |
| The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial 2023 · curcumin-piperine group · Adults aged 20–65 years with ischemic stroke in the rehabilitation phase, 3–6 months after the active stroke attack | 5 mg | 12 weeks | 33 |
| Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial 2025 · intervention group (curcumin-piperine) · Adults aged 20–75 with sepsis admitted to an ICU | 10 mg | 7 days | 33 |
| Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial 2023 · curcumin + piperine · Patients with moderate-to-high non-alcoholic fatty liver disease diagnosed by liver sonography; age and sex not specified | 5 mg | 12 weeks | 30 |
| Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation 2014 · trans-resveratrol with piperine · Adults described as healthy and young; age range and sex not specified | 20 mg | 1 day | 23 |
| Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial 2016 · curcuminoids group · Adults with mild-to-moderate primary knee osteoarthritis | 15 mg | 6 weeks | 19 |
| Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers 2013 · curcuminoid/piperine treatment · Healthy volunteers; age range and sex not specified | 48 mg | 2 days | 8 |
| Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial 2017 · curcuminoids · People with type 2 diabetes | 10 mg | 12 weeks | — |
| Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial 2019 · curcuminoids plus piperine · Adults with ultrasound-determined nonalcoholic fatty liver disease; age and sex not specified | 5 mg | 12 weeks | — |
| Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial 2020 · curcuminoids group · Patients with non-alcoholic fatty liver disease (NAFLD); age and sex not reported | 5 mg | 8 weeks | — |
| Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double-blind placebo-controlled trial 2020 · Curcuminoids · Critically ill patients aged 18–65 years with traumatic brain injury | 5 mg | 7 days | — |
| Ubiquitin Proteasome System Activity is Suppressed by Curcumin following Exercise-Induced Muscle Damage in Human Skeletal Muscle 2021 · curcumin (CUR) group · Recreationally active males and females aged 18–30 | 20 mg | 11 days | — |
| Cost-Effectiveness of Passion Fruit Albedo versus Turmeric in the Glycemic and Lipaemic Control of People with Type 2 Diabetes: Randomized Clinical Trial 2021 · CURPI group · Patients with type 2 diabetes; age and sex not specified | 5 mg | 120 days | — |
| Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial 2021 · Curcuma longa L. group · People with type 2 diabetes; age and sex not specified | 5 mg | 120 days | — |
| Turmeric supplementation with piperine is more effective than turmeric alone in attenuating oxidative stress and inflammation in hemodialysis patients: A randomized, double-blind clinical trial 2022 · turmeric/piperine · Hemodialysis patients aged 20–75 years | 2 mg | 12 weeks | — |
| Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial 2023 · curcumin-piperine · Patients with COVID-19 admitted to the intensive care unit; age and sex not specified | 15 mg | 7 days | — |
| Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery 2024 · Group B · Adults who underwent coronary artery bypass graft surgery | 5 mg | 5 days | — |
| Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery 2024 · Group C · Adults who underwent coronary artery bypass graft surgery | 10 mg | 5 days | — |
| Evaluation of the effectiveness of curcumin and piperine co-supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation, and clinical outcomes after coronary artery bypass graft surgery 2024 · Group D · Adults who underwent coronary artery bypass graft surgery | 15 mg | 5 days | — |
| Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial 2020 · Phytosomal curcumin · Adults aged 18–70 years with overweight (BMI 25–30 kg/m²) and suboptimal fasting plasma glucose (100–125 mg/dL) | 8 mg | 8 weeks | 40 |
