Nicotinamide Riboside
8 benefits mapped to clinical evidence across supplements.
Dose per serving from products
205 products in our catalogue print how much Nicotinamide Riboside a serving holds.
Most common: 250 mg to 500 mg, 51% of 205 products.
| Dose per serving | Products |
|---|---|
| 50 mg or less | 9 |
| 50 mg to 100 mg | 19 |
| 100 mg to 250 mg | 24 |
| 250 mg to 500 mg | 104 |
| 500 mg to 1 g | 35 |
| 1 g to 2.5 g | 14 |
Dose per serving from research
25 study groups in 16 studies say how much Nicotinamide Riboside participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 44% of 25 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg or less | 1 |
| 250 mg to 500 mg | 8 |
| 500 mg to 1 g | 11 |
| 1 g to 2.5 g | 4 |
| over 2.5 g | 1 |
Benefit Evidence
Research sources
Immune support (2)
- Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
PubMed ID: 34180141
COVID metabolic activator including NR reduced inflammatory markers and shortened recovery timeāimmunomodulatory signal (multiāagent).
- Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
PubMed ID: 39548320
COPD randomized trial showed reduced sputum ILā8 and neutrophils with NRāstrong evidence of reduced airway inflammation/immune modulation.
Cell health (2)
- Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
PubMed ID: 31278280
Large trial showed doseādependent, robust increases in blood NAD+ indicating strong target engagement for cellular resilience.
- The differential impact of three different NAD(+) boosters on circulatory NAD and microbial metabolism in humans
PubMed ID: 41540253
Wellācontrolled trial: NR/NMN roughly doubled wholeāblood NAD+ and detailed metabolomicsāstrong mechanistic support for cellular resilience.
Brain health (2)
- The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease
PubMed ID: 35235774
Phase I PD trial directly raised brain NAD+, altered cerebral metabolism and reduced inflammatory markersāstrong brain target engagement.
- Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
PubMed ID: 36703196
AD phase II CMA (including NR) improved cognitive scores and MRI/metabolomic markersāsupportive evidence for brain benefit (combination therapy).
Illness recovery (1)
- Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
PubMed ID: 34180141
4ācomponent metabolic activator including NR shortened COVID recovery time substantially versus placebo (attribution to NR uncertain).
Endurance (1)
- Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial
PubMed ID: 38871717
PAD trial increased 6āminute walk distance (clinically meaningful improvement in ambulatory stamina).
Muscle maintenance (1)
- Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial
PubMed ID: 38871717
PAD trial increased satellite cell abundance in muscle and improved walking distanceādirect muscle maintenance signal.
Workout performance (1)
- Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial
PubMed ID: 38871717
PAD randomized trial showed improved 6āminute walk distance and treadmill time in adherent participantsāclinically meaningful performance gains.
Mental clarity (1)
- Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
PubMed ID: 36703196
AD multiācomponent trial (including NR) produced notable cognitive score improvementsāsupports clarity though NR not isolated.
Forms of Nicotinamide Riboside
The form a label may print instead of Nicotinamide Riboside. Each is a different substance with its own identifier, and none of them has research of its own ā the studies are the ones on this page.
Similar by evidence
Supplements the same benefits carry qualifying findings for ā a fact about the evidence graph, not a recommendation to swap.
Products with Nicotinamide Riboside
Search all270 products whose verified label declares Nicotinamide Riboside ā not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet ā this is what the field is asking, not what it found.