Diosmin
8 benefits mapped to clinical evidence across supplements.
Dose per serving from products
73 products in our catalogue print how much Diosmin a serving holds.
Most common: 500 mg to 1 g, 48% of 73 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg to 5 mg | 14 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 1 |
| 50 mg to 100 mg | 0 |
| 100 mg to 250 mg | 8 |
| 250 mg to 500 mg | 12 |
| 500 mg to 1 g | 35 |
Dose per serving from research
18 study groups in 15 studies say how much Diosmin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 61% of 18 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg to 500 mg | 5 |
| 500 mg to 1 g | 11 |
| 1 g to 2.5 g | 2 |
Commonly used together
4 of 18 study groups took Diosmin with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Hesperidin | 3 |
Benefit Evidence
Venous tone/hemodynamics
Edema/symptoms -1.3%
Microcirculation/ulcers/healing
Capillary strength +60 mmHg
Venous symptoms -PTS 8.9%
Inflammation/edema improved
Venous tone/hemodynamics
Edema/symptoms -1.3%
Microcirculation/ulcers/healing
Capillary strength +60 mmHg
Venous symptoms -PTS 8.9%
Inflammation/edema improved
Research sources
Blood circulation (24)
- Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial
PubMed ID: 23761871
Increased frequency of clinically meaningful limb‑volume loss implies improved fluid/lymphatic handling.
- Venous tone: are the phlebotonic properties predictive of a therapeutic benefit? A comprehensive view of our experience with Daflon 500 mg
PubMed ID: 1792820
Pharmacoclinical trial showed rapid increases in venous tone and improvements in venous hemodynamic measures.
- A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility
PubMed ID: 8376915
Micronized diosmin+hesperidin markedly increased capillary resistance and reduced bleeding-related symptoms, indicating microvascular strengthening.
- Advantage of a micronized flavonoidic fraction (Daflon 500 mg) in comparison with a nonmicronized diosmin
PubMed ID: 8203783
Micronized diosmin/hesperidin produced better plethysmographic venous parameters vs nonmicronized diosmin.
- Controlled studies of Daflon 500 mg in chronic venous insufficiency
PubMed ID: 8203786
Pooled controlled studies consistently improved venous hemodynamics (capacitance, distensibility, emptying time).
- Laser Doppler and transcutaneous oximetry: modern investigations to assess drug efficacy in chronic venous insufficiency
PubMed ID: 8748889
Small increases in skin tcpO2 and decreases in tcpCO2 indicate improved tissue microcirculatory oxygenation.
- Low-molecular-weight heparins and Daflon for prevention of postoperative thromboembolism
PubMed ID: 8798349
Perioperative reduction of thromboembolic events when combined with LMWH suggests improved vascular outcomes.
- Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients
PubMed ID: 8995348
Adjunct to compression accelerated healing of venous leg ulcers, implying improved local venous circulation.
- Evaluation of haemorheological and microcirculatory disturbances in chronic venous insufficiency: activity of Daflon 500 mg
PubMed ID: 9477042
Two months of Daflon reduced stasis-induced RBC aggregation and favorably altered combined microcirculatory measures.
- Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer)
PubMed ID: 8995350
Daflon improved lymphatic migration speed and colloid half-life on lymphoscintigraphy in patients with more severe lymphedema.
- [Evaluation of clinical efficacy of a venotonic drug: lessons of a therapeutic trial with hemisynthesis diosmin in "heavy legs syndrome"]
PubMed ID: 9608923
Large comparative trial reported relief of ‘heavy legs’ symptoms (leg fatigue) with diosmin formulations.
- Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg ulcers associated with chronic venous insufficiency
PubMed ID: 12771852
Daflon added to compression accelerated venous ulcer healing and improved leg heaviness, indicating improved circulation.
- HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study
PubMed ID: 15678250
Modest decreases in resting skin flux and capillary filtration indicate microcirculatory improvement.
- [Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping]
PubMed ID: 16218350
Perioperative Detralex reduced postoperative hematoma size and bruising after saphenous stripping.
- [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study]
PubMed ID: 22929677
Perioperative use improved clinical severity and QoL after varicose vein treatment — systemic circulatory support implication.
- Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema
PubMed ID: 30343411
Randomized trial in upper‑limb lymphedema: diosmin‑containing product produced large and sustained %REV reductions vs control.
- [Endotheliotropic effects of venotonic drugs in treatment of patients with varicose veins]
PubMed ID: 30531772
Increased nitric‑oxide metabolites and reduced lipid peroxidation suggest improved endothelial/microcirculatory function.
- [Open prospective randomized study of the results of using Venarus in postthrombotic disease]
PubMed ID: 29688200
Improved venous tone and clinical symptoms in post‑thrombotic CVI when Venarus added to care.
- Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren(®)) in addition to conventional treatment in the management of patients with post-trauma/surgery persistent hand edema: a randomized controlled trial
PubMed ID: 30757911
Diosmin mix plus standard care reduced hand swelling and improved function after trauma/surgery, supporting lymphatic drainage.
- Diosmin 600 in adjunction to rivaroxaban reduces the risk of post-thrombotic syndrome after femoropopliteal deep vein thrombosis: results of the RIDILOTT DVT study
PubMed ID: 32348101
Large RCT showed faster/more complete vein recanalization and lower PTS incidence after DVT with diosmin.
- Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33808784
Placebo‑controlled trial showed reduced calf edema and improved VCSS/CIVIQ, reflecting better leg circulation.
- Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial
PubMed ID: 38109425
Strong postoperative RCT evidence (reduced swelling and pain) supports diosmin providing clinically relevant circulatory/venous support in the surgical setting.
- Venoactive drug treatment for patients with pelvic varicose veins: Results of the single-center, randomized, open-label study (VENOTREAT)
PubMed ID: 40855727
Diosmin-containing regimens produced relatively rapid reductions in venous pain in pelvic venous disease, consistent with improved venous function/tonus.
- Use of microcirculatory parameters to evaluate foam sclerotherapy treatment of superficial chronic venous disease, associated or not with venotonic drug: randomized, double-blind trial
PubMed ID: 40100057
MPFF (diosmin-containing) produced greater improvements in dermal microcirculatory parameters vs placebo when added to sclerotherapy, though some differences were borderline.
Vascular health (13)
- A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility
PubMed ID: 8376915
Micronized diosmin+hesperidin substantially increased capillary resistance and reduced capillary fragility symptoms with large measured effects.
- Controlled studies of Daflon 500 mg in chronic venous insufficiency
PubMed ID: 8203786
Pooled controlled trials demonstrated improvements in venous hemodynamics and symptoms in chronic venous insufficiency.
- Low-molecular-weight heparins and Daflon for prevention of postoperative thromboembolism
PubMed ID: 8798349
Perioperative addition of Daflon associated with elimination of symptomatic thromboembolism, suggesting vascular protective effects.
- Evaluation of haemorheological and microcirculatory disturbances in chronic venous insufficiency: activity of Daflon 500 mg
PubMed ID: 9477042
Improvements in RBC aggregation and microcirculatory measures support vascular function.
- [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study]
PubMed ID: 22929677
Perioperative Detralex improved venous clinical severity scores and QoL after endovascular varicose treatment.
- [Adjuvant phlebotrophic therapy and its effect on anti-inflammatory response after sclerotherapy]
PubMed ID: 27935886
Reduction in systemic/local inflammatory markers after sclerotherapy supports vessel health protection.
- Efficacy and Safety of Daflon® in the Treatment of Idiopathic Epistaxis
PubMed ID: 30394805
Large open‑label epistaxis cohort with reduced severe bleeding points to improved mucosal vessel stability.
- [Endotheliotropic effects of venotonic drugs in treatment of patients with varicose veins]
PubMed ID: 30531772
Improved NO metabolites and reduced oxidative stress indicate enhanced endothelial and vascular health.
- Diosmin 600 in adjunction to rivaroxaban reduces the risk of post-thrombotic syndrome after femoropopliteal deep vein thrombosis: results of the RIDILOTT DVT study
PubMed ID: 32348101
Major clinical improvements in PTS prevention and vein recanalization demonstrate strong vascular protective effects.
- Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33808784
Improvements in VCSS, pain and QoL indicate reduced symptoms associated with varicose veins.
- Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial
PubMed ID: 38109425
Clinically meaningful reductions in postoperative swelling and pain imply beneficial effects on venous/vascular function in the surgical setting.
- Venoactive drug treatment for patients with pelvic varicose veins: Results of the single-center, randomized, open-label study (VENOTREAT)
PubMed ID: 40855727
Randomized trial in pelvic venous disease showed clinically meaningful and relatively rapid reductions in venous pain with diosmin-containing regimens; relevant to venous discomfort broadly.
- Use of microcirculatory parameters to evaluate foam sclerotherapy treatment of superficial chronic venous disease, associated or not with venotonic drug: randomized, double-blind trial
PubMed ID: 40100057
MPFF added to sclerotherapy produced modestly better microcirculatory and clinical outcomes, suggesting symptomatic benefit for venous disease adjunctive to procedures.
Tissue repair (9)
- Low-molecular-weight heparins and Daflon for prevention of postoperative thromboembolism
PubMed ID: 8798349
Addition of Daflon to LMWH perioperatively was associated with elimination of symptomatic DVT/PE in the trial, improving postoperative safety.
- Micronized purified flavonoid fraction in pretreating CABG patients
PubMed ID: 20401289
Short pre-op Daflon associated with lower cardiac injury markers and better functional class after CABG.
- How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy
PubMed ID: 21472103
Observer-blinded RCT: diosmin after hemorrhoid surgery reduced pain/bleeding and shortened hospital stay.
- [On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study]
PubMed ID: 22929677
Perioperative Detralex improved clinical severity and QoL when added to endovascular varicose treatment.
- Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial
PubMed ID: 27815700
Post‑hemorrhoid surgery diosmin product lowered postoperative bleeding/thrombosis and pain, speeding recovery.
- [Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping]
PubMed ID: 16218350
Perioperative Detralex reduced pain and hematoma and improved QoL after vein stripping, accelerating recovery.
- Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy
PubMed ID: 7648143
Post-haemorrhoidectomy Daflon reduced secondary bleeding incidence, improving postoperative course.
- Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema
PubMed ID: 30343411
Addition of diosmin improved lymphedema outcomes post‑treatment, suggesting faster functional recovery.
- Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial
PubMed ID: 38109425
Large RCT after knee replacement showed diosmin reduced swelling and pain in the early postoperative period, indicating faster symptomatic recovery.
Swelling relief (11)
- Effect of Pycnogenol on the Healing of Venous Ulcers
PubMed ID: 27521821
Diosmin/hesperidin produced significant decreases in limb circumference in venous ulcer patients.
- [Open prospective randomized study of the results of using Venarus in postthrombotic disease]
PubMed ID: 29688200
Reported symptomatic improvement and venous tone improvement in post‑thrombotic patients includes reduced edema.
- Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren(®)) in addition to conventional treatment in the management of patients with post-trauma/surgery persistent hand edema: a randomized controlled trial
PubMed ID: 30757911
Diosmin product plus standard care significantly reduced hand edema vs control after trauma/surgery.
- Diosmin 600 in adjunction to rivaroxaban reduces the risk of post-thrombotic syndrome after femoropopliteal deep vein thrombosis: results of the RIDILOTT DVT study
PubMed ID: 32348101
Marked clinical improvements after DVT, including less edema and better vein recanalization, reduce ankle swelling risk.
- Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33808784
Placebo‑controlled trial showed significant and clinically meaningful calf circumference decreases at 4 and 8 weeks.
- Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial
PubMed ID: 38109425
Strong multicenter RCT showed consistent, significant reductions in lower-extremity swelling after knee replacement with diosmin vs control.
- Efficacy and Safety of the Phytochemical Product Linfadren in the Management of Patients With Persistent Ankle Edema Following Trauma or Surgery: A Randomized Controlled Trial
PubMed ID: 37724868
Randomized trial of Linfadren (diosmin-containing) showed ~4–5% reduction in ankle circumference vs control at follow-up, a clear effect on ankle swelling (product was multi-ingredient).
- Controlled studies of Daflon 500 mg in chronic venous insufficiency
PubMed ID: 8203786
Pooled studies showed improved venous hemodynamics which are associated with reduced edema in CVI.
- Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer)
PubMed ID: 8995350
Lymphoscintigraphy improvements in severe lymphedema subgroup suggest beneficial effect on swelling in that group.
- Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema
PubMed ID: 30343411
Randomized trial: diosmin‑containing product produced large reductions in excess limb volume and %REV in lymphedema.
- Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial
PubMed ID: 23761871
Increased chance of ≥100 mL limb‑volume loss indicates meaningful reduction of limb swelling.
Bowel regularity (11)
- Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids
PubMed ID: 1425054
Early objective improvement at day 4 (but no sustained benefit at two weeks) indicates transient hemorrhoid symptom benefit.
- Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids
PubMed ID: 8203789
Double-blind trial: micronized flavonoid fraction accelerated symptom relief and reduced analgesic use in acute hemorrhoid attacks.
- Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo
PubMed ID: 8203790
Duplicate entry for emphasis: Daflon strongly reduced hemorrhoid symptoms and attacks vs placebo.
- Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy
PubMed ID: 7648143
Postoperative Daflon reduced secondary bleeding after haemorrhoidectomy, reducing hemorrhoid-related complications.
- Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial
PubMed ID: 10813126
MPFF plus fiber markedly shortened time to cessation of hemorrhoidal bleeding vs fiber or banding.
- The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes
PubMed ID: 16846547
Double‑blind RCT found MPFF significantly reduced pain, oedema and bleeding over 7 days.
- How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy
PubMed ID: 21472103
Post-hemorrhoidectomy diosmin reduced pain and bleeding and shortened hospital stay.
- Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis
PubMed ID: 22069954
Open series of flavonoid/triterpene product produced large rapid improvements in hemorrhoidal grade, bleeding and pain.
- Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial
PubMed ID: 25893991
Randomized triple‑blind trial showed faster control of pain, bleeding and edema in acute hemorrhoids with diosmin mix.
- Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial
PubMed ID: 27815700
Postoperative diosmin‑containing Venoplant significantly reduced bleeding, thrombosis and pain after hemorrhoid surgery.
- [A multicenter, randomized controlled trial of wheat cellulose particles in the treatment of internal hemorrhoids]
PubMed ID: 28722093
Combination of fiber + diosmin greatly increased short‑term clinical effectiveness in internal hemorrhoids vs diosmin alone.
Muscle cramps (6)
- Controlled studies of Daflon 500 mg in chronic venous insufficiency
PubMed ID: 8203786
Pooled studies show clinical symptom improvement in CVI including pain/heaviness which maps to fewer cramps/pain.
- Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients
PubMed ID: 8995348
Improved ulcer healing and symptoms includes pain reductions in venous leg ulcer patients.
- Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg ulcers associated with chronic venous insufficiency
PubMed ID: 12771852
Improvement in heavy‑leg sensation and symptoms with Daflon suggests less pain/cramping.
- Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 33808784
Significant pain (VAS) reduction in placebo‑controlled trial implies fewer leg pain/cramps with diosmin.
- Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial
PubMed ID: 38109425
Diosmin significantly reduced postoperative pain on movement vs control, supporting reduced limb pain in this context.
- Venoactive drug treatment for patients with pelvic varicose veins: Results of the single-center, randomized, open-label study (VENOTREAT)
PubMed ID: 40855727
Diosmin-containing regimens reduced pelvic venous pain substantially; relevant evidence for venous-related pain relief.
Inflammation (3)
- [Adjuvant phlebotrophic therapy and its effect on anti-inflammatory response after sclerotherapy]
PubMed ID: 27935886
Clear, significant reductions in CRP, histamine, IL‑1, TNF‑α and VEGF after sclerotherapy.
- Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial
PubMed ID: 25893991
Faster resolution of edema/thrombosis and pain/bleeding in acute hemorrhoids implies anti‑inflammatory effect.
- How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy
PubMed ID: 21472103
Post-hemorrhoidectomy trial showed reduced pain/bleeding and faster recovery, consistent with anti‑inflammatory or symptomatic anti‑inflammatory effects.
Antioxidant (1)
- [Endotheliotropic effects of venotonic drugs in treatment of patients with varicose veins]
PubMed ID: 30531772
Significant fall in malondialdehyde (lipid peroxidation) after 2 months indicates antioxidant effect.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Diosmin
Search all106 products whose verified label declares Diosmin — not every bottle that mentions it in a title.