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Grape Seed Extract

13 benefits mapped to clinical evidence across supplements.

Dose per serving from products

1,856 products in our catalogue print how much Grape Seed Extract a serving holds.

Most common: 50 mg to 100 mg, 33% of 1,856 products.

Dose per servingProducts
2.5 mg or less
37
2.5 mg to 5 mg
83
5 mg to 10 mg
86
10 mg to 25 mg
300
25 mg to 50 mg
377
50 mg to 100 mg
606
100 mg to 250 mg
238
250 mg to 500 mg
113
over 500 mg
16

Dose per serving from research

31 study groups in 26 studies say how much Grape Seed Extract participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 48% of 31 study groups.

Daily doseStudy groups
50 mg or less
1
50 mg to 100 mg
4
100 mg to 250 mg
9
250 mg to 500 mg
15
over 500 mg
2

See every study group

Commonly used together

7 of 31 study groups took Grape Seed Extract with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Arginine
4

Benefit Evidence

BP↓, lipids↓

Hemorrhage↓, circulation↑

1,299 people
Heart health
Moderate

Lipids, −20% LDL

Blood pressure, −13.1 mmHg

Oxidative stress, −37.5% CRP

675 people
Wellbeing
Moderate

Metabolic/inflammatory improvement

Venous symptoms/QoL

903 people

Blood pressure/endothelial +6.4

Venous reflux/bleeding -2490 ms

1,075 people
Antioxidant
Moderate

Antioxidant markers +52%

Oxidative stress ↓

Inflammation ↓

478 people

Skin + density

Lipids, inflammation, BP

421 people
Inflammation
Moderate

↓ TNF-α/hsCRP

↓ inflammatory genes

308 people

Barrier/moisture +1

Pigment/texture/wrinkles +

373 people
Skin repair
Moderate

Healing time -50%

Periodontal scores improved

236 people

Inflammation -IL-6, TNF-α

Antibacterial support -streptococci

130 people

Healing time -6d

Healing score better

164 people

Fatigue threshold +22%

Threshold power +5%

91 people

Hard exudates improved +35.9%

Macular thickness/volume decreased

124 people

Research sources

Blood circulation (12)
  1. Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial

    PubMed ID: 39009117

    Large noninferiority RCT in chronic venous disease demonstrating symptomatic and QoL improvements versus an active flavonoid comparator.

  2. Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial

    PubMed ID: 39410893

    Postpartum trial reported decreased uterine bleeding with grape seed extract (in multi-extract context) indicating an effect on bleeding/hemostasis and local blood-flow/vascular response.

  3. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study

    PubMed ID: 11508317

    Human trial in hypercholesterolemia showed modest lipid changes and reduced oxidized‑LDL antibodies, relevant to vascular health.

  4. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy

    PubMed ID: 31124931

    One-year RCT with GSPE improved retinal exudates and macular measures, directly implicating microvascular (microcirculatory) benefits in the eye.

  5. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial

    PubMed ID: 37375586

    Combination nutraceutical that included GSE produced meaningful LDL reductions vs diet; GSE contribution uncertain but supports circulation benefit.

  6. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery

    PubMed ID: 28074795

    Postoperative improvement in LVEF and reduced oxidative stress implies improved central hemodynamics and perfusion in an ischemia-reperfusion setting.

  7. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia

    PubMed ID: 23437789

    Improved lipid profile and reduced ox-LDL in mild hyperlipidemia can support vascular health.

  8. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial

    PubMed ID: 26568249

    ≈6-week RCT in prehypertensive adults: significant reductions in SBP and DBP (clinically meaningful).

  9. Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed ID: 31757033

    12-week RCT in prehypertensive adults: meaningful reductions in SBP/DBP and large improvements in arterial stiffness (PWV) especially in non-smokers.

  10. Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

    PubMed ID: 33671310

    16-week RCT showed modest overall BP effects with a significant subgroup effect in men.

  11. The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

    PubMed ID: 38755622

    NAFLD RCT produced substantial reductions in SBP and other cardiometabolic parameters, indicating improved vascular/circulatory status.

  12. Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial

    PubMed ID: 41242464

    Large RCT showed objective improvements in venous hemodynamics (venous reflux time) and symptoms in varicose veins.

Heart health (12)
  1. Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed ID: 31757033

    Large BP and arterial-stiffness reductions in prehypertensives, effects relevant to cardiac risk and function.

  2. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study

    PubMed ID: 11508317

    Small RCT in hypercholesterolemics showed modest lipid effects and reduced anti‑OxLDL antibodies; combination with chromium produced larger lipid reductions.

  3. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial

    PubMed ID: 37375586

    Multi-ingredient nutraceutical including GSE lowered LDL in RCT — cardiovascular marker improvement though attribution to GSE alone unclear.

  4. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

    PubMed ID: 19646193

    Type 2 diabetes RCT reduced hsCRP and slightly lowered total cholesterol; anti‑inflammatory/antioxidant changes relevant to cardiac health.

  5. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery

    PubMed ID: 28074795

    Randomized study showed reduced oxidative stress and a clinically relevant +6.4% LVEF improvement after CABG—direct cardiac functional benefit.

  6. Beneficial effects of grape seed extract on malondialdehyde-modified LDL

    PubMed ID: 17616006

    Lowered MDA-LDL/oxidized LDL markers over 6–12 weeks—supports anti-atherogenic cardiac benefit (indirect).

  7. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia

    PubMed ID: 23437789

    Improved LDL and total cholesterol plus reduced oxidized LDL in mild hyperlipidemia (cardiovascular risk reduction).

  8. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial

    PubMed ID: 26568249

    SBP/DBP reductions in prehypertensive adults (cardiac risk factor improvement).

  9. The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

    PubMed ID: 27191247

    Increased PON activity and apo-AI with reductions in LDL/TC/TG—favorable cardiometabolic biomarker changes.

  10. The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

    PubMed ID: 38755622

    NAFLD RCT demonstrated improvements in LDL-C, blood pressure and insulin resistance—markers strongly linked to cardiovascular risk.

  11. Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers

    PubMed ID: 33671310

    Modest BP benefit in men over 16 weeks indicates some cardiovascular support in a subgroup.

  12. Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial

    PubMed ID: 33044768

    12-week trial showed improved lipid profile (lower LDL, higher HDL) alongside calorie restriction, supporting heart-related benefit though diet confounds attribution.

Wellbeing (9)
  1. The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

    PubMed ID: 38755622

    Broad metabolic, BP and liver improvements in NAFLD patients imply substantial overall health/wellness benefit.

  2. Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial

    PubMed ID: 39009117

    VV seed extract produced QoL improvements in chronic venous disease comparable to standard treatment.

  3. The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial

    PubMed ID: 31713941

    12-week trial with calorie restriction: greater weight/waist reductions and lower inflammatory markers—meaningful wellness outcomes.

  4. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study

    PubMed ID: 24518152

    Middle-aged women: reduced hot flashes and insomnia and modest BP reductions—benefits to daily wellness.

  5. Grape seed extract supplementation in non-alcoholic fatty liver disease

    PubMed ID: 38419408

    NAFLD trial showed reduced inflammation/oxidative stress and improved SF-36 quality-of-life scores.

  6. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

    PubMed ID: 19646193

    Human RCT in T2D improved glycemic (fructosamine), antioxidant (GSH), and inflammatory (hsCRP) markers, implying broad wellness benefits.

  7. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer

    PubMed ID: 25150117

    Multi-herb adjunct (includes GSE) in metastatic colorectal cancer lowered progression and severe AEs during treatment — general supportive effect though mixed product.

  8. Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children

    PubMed ID: 37832335

    Adjunctive GSPE reduced iron burden markers and improved oxidative/inflammatory markers in β-thalassemia children — multi-domain clinical improvements.

  9. Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial

    PubMed ID: 41242464

    Large RCT showed clinically meaningful symptom and QoL improvements in patients with varicose veins.

Vascular health (8)
  1. Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial

    PubMed ID: 39410893

    Reduced postpartum bleeding in women taking grape seed extract suggests improved hemostasis/capillary integrity in that clinical setting (multi-extract trial).

  2. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy

    PubMed ID: 31124931

    GSPE produced clinically meaningful improvements in retinal hard exudates and macular volume in diabetic retinopathy — indicates improved microvascular integrity.

  3. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery

    PubMed ID: 28074795

    Improved postoperative LVEF and reduced oxidative stress imply improved myocardial and vascular outcomes in ischemia–reperfusion.

  4. Beneficial effects of grape seed extract on malondialdehyde-modified LDL

    PubMed ID: 17616006

    Reduced oxidized LDL (less vascular oxidative injury) supports vessel health.

  5. The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

    PubMed ID: 27191247

    Improved PON activity and lipid profile may reduce vascular damage and support vessel integrity (indirect).

  6. Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study

    PubMed ID: 31757033

    Substantial reductions in PWV and stiffness β with 12 weeks of GSPE indicate improved vascular (arterial) wall function/strength.

  7. Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial

    PubMed ID: 39009117

    Noninferior symptomatic and QoL improvements versus standard flavonoid therapy in chronic venous disease imply improved venous/vascular strength.

  8. Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial

    PubMed ID: 41242464

    Robust objective improvements in venous reflux time and symptomatic/QoL measures indicate strengthened venous function and vessel competence.

Antioxidant (9)
  1. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery

    PubMed ID: 28074795

    Increased total antioxidant capacity and decreased MDA in CABG patients (direct antioxidant biomarkers).

  2. Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children

    PubMed ID: 37832335

    Pediatric RCT adjunct to chelation increased GSH and decreased MDA — clear antioxidant marker changes in humans.

  3. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

    PubMed ID: 19646193

    Crossover RCT in type 2 diabetes increased whole-blood GSH and lowered hsCRP, consistent with antioxidant activity in humans.

  4. The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

    PubMed ID: 27191247

    Increased paraoxonase activity and apo-AI with concomitant lipid improvements, consistent with antioxidant/anti-atherogenic effects.

  5. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia

    PubMed ID: 23437789

    Reduced oxidized LDL and improved lipid profile in an 8-week RCT (direct oxidation markers).

  6. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects

    PubMed ID: 22776850

    Modulated oxidative-stress biomarkers and redox-related gene expression in obese adults (biological antioxidant activity).

  7. Role of multi-component functional foods in the complex treatment of patients with advanced breast cancer

    PubMed ID: 18389773

    Multi-component diet including grape seed products reduced oxidative-stress markers (confounded but supportive).

  8. Beneficial effects of grape seed extract on malondialdehyde-modified LDL

    PubMed ID: 17616006

    Lowered MDA-LDL and oxidized LDL in mildly hyperlipidemic subjects over 6–12 weeks (direct oxidative stress markers).

  9. Grape seed extract supplementation in non-alcoholic fatty liver disease

    PubMed ID: 38419408

    MDA reductions reported in NAFLD RCT (reduced oxidative stress).

Healthy aging (7)
  1. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects

    PubMed ID: 22776850

    Redox-gene modulation and antioxidant biomarker changes that may contribute to healthy aging (biological plausibility).

  2. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia

    PubMed ID: 23437789

    Reduced oxidized LDL and improved cholesterol profile may reduce age-related vascular risk.

  3. The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

    PubMed ID: 27191247

    Improved PON activity and lipid profile—mechanisms linked to reduced oxidative damage relevant to aging.

  4. The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

    PubMed ID: 38755622

    Improvements in metabolic risk factors, BP and liver health in NAFLD patients support factors associated with healthy aging.

  5. Effect of a novel dietary supplement on skin aging in post-menopausal women

    PubMed ID: 16670692

    6-month multi-ingredient supplement that included grape seed improved facial skin appearance and density in postmenopausal women (clinical outcomes, combo product).

  6. Comparative effect of grape seed extract (Vitis vinifera) and ascorbic acid in oxidative stress induced by on-pump coronary artery bypass surgery

    PubMed ID: 28074795

    Reduced oxidative stress and improved cardiac function post-CABG—supports organ resilience, relevant to aging contexts.

  7. Grape seed extract supplementation in non-alcoholic fatty liver disease

    PubMed ID: 38419408

    Lowered IL‑6 and MDA in NAFLD patients—reduced inflammation/oxidative stress are aging-relevant processes.

Inflammation (7)
  1. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

    PubMed ID: 19646193

    Type 2 diabetes crossover RCT lowered hsCRP markedly, indicating an anti-inflammatory response.

  2. Grape seed extract supplementation in non-alcoholic fatty liver disease

    PubMed ID: 38419408

    Significant IL‑6 reductions and improved oxidative markers in NAFLD patients indicate anti-inflammatory effects.

  3. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects

    PubMed ID: 22776850

    Redox/gene-expression modulation in obese adults consistent with improved inflammatory/redox balance.

  4. The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial

    PubMed ID: 31713941

    Decreases in TNF‑α and hs‑CRP with 12-week GSE during calorie restriction (clear anti-inflammatory biomarker changes).

  5. The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

    PubMed ID: 38755622

    NAFLD RCT showed improvements in liver enzymes and hepatic steatosis, indicating reduced hepatic inflammation and metabolic inflammation.

  6. Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children

    PubMed ID: 37832335

    Pediatric RCT showed reductions in TNF-α and hs-CRP and improved liver enzymes — clear anti-inflammatory changes in humans.

  7. Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults

    PubMed ID: 26652026

    Topical cream with grape-seed procyanidins accelerated improvement in atopic dermatitis severity (clinical anti-inflammatory skin effect; combo product).

Skin appearance (6)
  1. The topical effect of grape seed extract 2% cream on surgery wound healing

    PubMed ID: 25948437

    Topical 2% GSE cream halved average wound-healing time vs placebo (large, clinically meaningful improvement in skin healing/appearance).

  2. Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study

    PubMed ID: 25349107

    Sunscreen supplemented with antioxidant cocktail (includes GSE) reduced IRA-induced MMP-1 upregulation — molecular protection relevant to photoaging.

  3. Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults

    PubMed ID: 26652026

    Topical cream containing grape-seed procyanidins improved mild‑to‑moderate facial atopic dermatitis severity faster vs placebo (clinical skin benefit; combo product).

  4. Effect of grape seed extract ointment on cesarean section wound healing: A double-blind, randomized, controlled clinical trial

    PubMed ID: 31003677

    5% GSE ointment improved cesarean wound REEDA scores at days 6 and 14 vs petrolatum (well-powered RCT showing better healing/appearance).

  5. A new product of multi-plant extracts improved skin photoaging: An oral intake in vivo study

    PubMed ID: 34791771

    Multi-plant oral supplement including GSE produced objective improvements in skin barrier, hydration, elasticity and pigmentation in middle-aged adults (combo product).

  6. Effect of a novel dietary supplement on skin aging in post-menopausal women

    PubMed ID: 16670692

    6-month multi-ingredient supplement (includes GSE) improved facial skin appearance and ultrasound-measured skin density in postmenopausal women.

Skin repair (3)
  1. Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets

    PubMed ID: 34281305

    Intra-pocket application of GSE as adjunct to periodontal therapy improved probing depth and attachment at 3 months, indicating enhanced local wound/healing support.

  2. The topical effect of grape seed extract 2% cream on surgery wound healing

    PubMed ID: 25948437

    Topical 2% GSE cream halved healing time vs placebo with large, statistically significant improvements (direct wound-recovery evidence).

  3. Effect of grape seed extract ointment on cesarean section wound healing: A double-blind, randomized, controlled clinical trial

    PubMed ID: 31003677

    5% GSE ointment significantly improved cesarean wound healing REEDA scores (robust clinical evidence for wound support).

Immune support (3)
  1. Grape seed extract supplementation in non-alcoholic fatty liver disease

    PubMed ID: 38419408

    Reduced IL-6 (inflammatory cytokine) in NAFLD patients, indicating immune/inflammatory modulation.

  2. The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial

    PubMed ID: 31713941

    Decreases in TNF-α and hs-CRP with 12-week GSE during calorie restriction (anti-inflammatory/immune modulation).

  3. Antibacterial Efficacy of Mouthwash Prepared from Pomegranate, Grape Seed and Guava Extracts against Oral Streptococci: An in Vivo Study

    PubMed ID: 29087796

    Topical mouthwash reduced salivary Streptococci in children (antimicrobial effect relevant to oral immune defense).

Joints & tendons (2)
  1. The topical effect of grape seed extract 2% cream on surgery wound healing

    PubMed ID: 25948437

    Marked acceleration of wound re-epithelialization suggests enhanced extracellular matrix/collagen-mediated repair (plausible mechanism).

  2. Effect of grape seed extract ointment on cesarean section wound healing: A double-blind, randomized, controlled clinical trial

    PubMed ID: 31003677

    Improved cesarean wound healing scores with topical GSE consistent with enhanced tissue repair/collagen deposition.

Exercise recovery (2)
  1. Effects of arginine-based supplements on the physical working capacity at the fatigue threshold

    PubMed ID: 20386475

    Four-week arginine-based supplement containing 300 mg GSE increased electromyographic fatigue threshold in men — multi-ingredient but human evidence of improved submaximal performance.

  2. The effects of 4 weeks of an arginine-based supplement on the gas exchange threshold and peak oxygen uptake

    PubMed ID: 20555372

    Arginine-based supplement with 300 mg GSE increased gas-exchange threshold and power at threshold in humans (no peak VO2 change); grape seed was a component.

Eye health (1)
  1. Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy

    PubMed ID: 31124931

    One-year multicenter RCT showed GSPE increased the proportion of diabetic retinopathy patients with improved retinal hard exudates and reduced macular volume — strong eye/microvascular benefit.

Similar by evidence

Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.

Products with Grape Seed Extract

Search all

4124 products whose verified label declares Grape Seed Extract — not every bottle that mentions it in a title.

Being studied right now

Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.