Vitamin D3-K2 10,000

What the brand says

D3-K2 Vitamin 10,000 provides vitamin K2 as menaquinone-7 (MK-7), a highly bioavailable and bioactive form of K2. K2 Vitamin D3 also features vitamin D3 (cholecalciferol), the identical form in which vitamin D is derived in the body from cholesterol and synthesized by sunlight on the skin. Historical use and numerous studies have demonstrated the efficacy of vitamin K supplements for bone and cardiovascular health. MK-7 Bioavailability Increases Extrahepatic Tissue Utilization Schurgers et al conducted human studies to compare the in vivo properties of orally administered K1 and MK-7. The results supported better bioavailability and utilization of MK-7. Expressed as AUC96, MK-7 demonstrated a six-fold better half-life, a seven- to eight-fold higher dose- response level, and a three times higher carboxylated to uncarboxylated osteocalcin ratio (cOC:ucOC). Furthermore, on a molar basis, MK-7 is a three-to-four times more potent antidote for oral anticoagulation than is K1. Researchers note that, aside from sensitive individuals, “MK-7 supplements containing more than 50 mcg/d may interfere with oral anticoagulant treatment, whereas doses of at least 50 mcg are not likely to affect the INR value in a relevant way.”[2] Nonetheless, practitioners should closely monitor patients taking anticoagulants