Sesamin
8 benefits mapped to clinical evidence across supplements.
Dose per serving from research
6 study groups in 6 studies say how much Sesamin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 50% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 3 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 0 |
| 50 mg to 100 mg | 1 |
| 100 mg to 250 mg | 2 |
Benefit Evidence
Research sources
Antioxidant (3)
- Improvement of liver function in humans using a mixture of schisandra fruit extract and sesamin
PubMed ID: 22610748
Schisandra+sesamin product improved LDL oxidation lag time and antioxidant markers in people with borderline liver enzymes (combination product).
- Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis
PubMed ID: 26151734
RA trial: sesamin lowered MDA and raised total antioxidant capacity, directly supporting antioxidant activity.
- Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue
PubMed ID: 26153159
Sesame lignans + vitamin E increased LDL resistance to oxidation in a large trial, consistent with antioxidant activity (combination product).
Inflammation (2)
- A randomized, triple-blind, placebo-controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical indices in women with rheumatoid arthritis
PubMed ID: 31309643
Tripleâblind RCT in RA showed significant decreases in hsâCRP, TNFâα, COXâ2 and proteolytic enzymes plus reduced pain and tender jointsâstrong antiâinflammatory evidence in this population.
- Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies
PubMed ID: 19786646
Sesame reduced an inflammatory eicosanoid (20âHETE) by ~30% in a randomized crossover, consistent with antiâinflammatory mechanism via CYP4F2 inhibition.
Vitality (1)
- Sesame Lignans and Vitamin E Supplementation Improve Subjective Statuses and Anti-Oxidative Capacity in Healthy Humans With Feelings of Daily Fatigue
PubMed ID: 26153159
Large RCT of sesame lignans + vitamin E reported improved subjective fatigue, sleep and appearance, supporting perceived energy/vitality improvements (combination product).
Cholesterol (1)
- Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis
PubMed ID: 26151734
RA trial: sesamin increased HDL-cholesterol alongside antioxidant improvements (small study, short duration).
Joint comfort (1)
- A randomized, triple-blind, placebo-controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical indices in women with rheumatoid arthritis
PubMed ID: 31309643
In women with RA, sesamin reduced inflammatory and jointâdamage biomarkers and produced clinically meaningful reductions in pain and tender joint count.
Liver support (1)
- Improvement of liver function in humans using a mixture of schisandra fruit extract and sesamin
PubMed ID: 22610748
Schisandra+sesamin product reduced ALT and AST in people with borderline elevated liver enzymes (randomized controlled trial), supporting liver enzyme improvement albeit as a combo product.
Blood circulation (1)
- Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies
PubMed ID: 19786646
Large reductions in circulating and urinary 20âHETE (~30%) indicate modulation of vasoactive eicosanoids, relevant to vascular/circulatory biology.
Metabolism (1)
- Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies
PubMed ID: 19786646
Sesame reduced circulating and urinary 20âHETE (~30%) by inhibiting CYP4F2-mediated metabolism of eicosanoids, a metabolic enzyme effect.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Sesamin
Search all31 products whose verified label declares Sesamin â not every bottle that mentions it in a title.