Red Clover
10 benefits mapped to clinical evidence across supplements.
Dose per serving from products
98 products in our catalogue print how much Red Clover a serving holds.
Most common: 50 mg to 100 mg, 26% of 98 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 5 |
| 25 mg to 50 mg | 18 |
| 50 mg to 100 mg | 25 |
| 100 mg to 250 mg | 15 |
| 250 mg to 500 mg | 15 |
| 500 mg to 1 g | 20 |
Dose per serving from research
27 study groups in 21 studies say how much Red Clover participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg, 63% of 27 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 8 |
| 50 mg to 100 mg | 17 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 0 |
| 500 mg to 1 g | 1 |
| over 1 g | 1 |
Benefit Evidence
Research sources
Hormone balance (11)
- The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women
PubMed ID: 21870906
Crossover study showed large reductions in hot flushes, night sweats and Kupperman Index â robust menopausal symptom relief.
- Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women
PubMed ID: 16513301
Crossover study in ~109 postmenopausal women found increased testosterone and reduced endometrial thickness â direct hormonal effects.
- The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study
PubMed ID: 16373244
90âday crossover reduced menopausal symptoms (Kupperman index) and improved vaginal cytology â clinically relevant benefit.
- Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo
PubMed ID: 12161042
Randomized doubleâblind trial in postmenopausal women showed a substantial (44%) greater reduction in hot flush frequency vs placebo over 12 weeks â strong evidence for vasomotor symptom relief at tested dose.
- Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms
PubMed ID: 28591133
12âweek RCT (with probiotic) markedly lowered physiological and selfâreported hotâflush frequency/intensity â strong symptomatic benefit.
- Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial
PubMed ID: 41305622
Polyphenol mixture including red clover produced clinically relevant hot-flush and menopause-domain improvements in equol-producer subgroups.
- Disposition of Dietary Polyphenols in Breast Cancer Patients' Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin
PubMed ID: 33939887
Isoflavone-derived metabolites from a multi-extract intervention exhibited estrogenic activity in vitro and were present in tissues â supports hormone-modulating potential.
- Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
PubMed ID: 28768651
Red clover extract plus probiotics altered estrogen metabolite ratios (2âOH:16ÎąâOH) and increased equol production â indicative of hormone metabolism effects (adjuncts given).
- Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial
PubMed ID: 25581426
12âweek red clover leaf RCT significantly reduced Menopause Rating Scale total and symptom domains.
- Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile
PubMed ID: 24283160
150âparticipant RCT showed prompt significant reductions in hot flushes and menopausal index without lipid/coagulation changes.
- Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial
PubMed ID: 39254422
Prospective randomized placebo-controlled trial showed consistent, significant improvements in Menopause Rating Scale scores over 3â6 months.
Heart health (5)
- Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial
PubMed ID: 39254422
Significant improvements in total cholesterol, LDL-C, triglycerides and HDL observed in the isoflavone RCT â metrics linked to cardiovascular risk.
- A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men
PubMed ID: 14985677
Biochaninâenriched red clover lowered LDL by ~9.5% in men â lipid improvement relevant to heart health.
- Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index
PubMed ID: 19031218
90-day crossover reported reductions in total and LDL cholesterol in overweight postmenopausal women (subgroup effect) â supports cardiometabolic benefit in some populations.
- Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women
PubMed ID: 12714433
Formononetinârich isoflavones reduced arterial stiffness and total peripheral resistance â vascular benefit relevant to heart health.
- The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism
PubMed ID: 11449083
Reported significant increases in HDL and decreases in apolipoprotein B â favorable lipid changes relevant to heart health (open-label limitations noted).
Cholesterol (5)
- Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index
PubMed ID: 19031218
Decreases in total and LDL cholesterol in overweight subgroup over 90 days â supports benefit in a defined population.
- Influence of red clover-derived isoflavones on serum lipid profile in postmenopausal women
PubMed ID: 20144173
Oneâyear supplementation study reported improved cholesterol profile (LDL/total down, HDL up) vs controls.
- Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial
PubMed ID: 39254422
RCT reported decreases in total cholesterol and LDL-C and improvements in triglycerides/HDL over 3â6 months.
- The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism
PubMed ID: 11449083
Significant HDL increase and ApoB decrease reported over 6 months â favorable lipid changes relevant to cholesterol health.
- A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men
PubMed ID: 14985677
Biochaninâenriched preparation lowered LDL â9.5% in men (sexâspecific effect).
Wellbeing (4)
- Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial
PubMed ID: 41305622
RCT of a polyphenol mixture including red clover produced meaningful QoL and menopause-domain improvements in equol-producer subgroups.
- Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extracts
PubMed ID: 19948385
Marked reductions in anxiety/depression scores indicate improved overall wellâbeing.
- The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women
PubMed ID: 21870906
Large crossover study with major reductions in vasomotor and menopausal scores â likely improves overall quality of life.
- Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial
PubMed ID: 39254422
Significant reductions in Menopause Rating Scale indicate meaningful improvement in menopausal symptoms and related overall wellâbeing.
Bone health (3)
- Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial
PubMed ID: 28768651
12âmonth RCE + probiotics in osteopenic postmenopausal women attenuated lumbar spine BMD loss and improved bone markers (tested with adjunct supplements).
- The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism
PubMed ID: 11449083
Sixâmonth study reported increased proximal forearm bone density in dose groups, though lacked a concurrent control â supportive but limited.
- The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial
PubMed ID: 14749241
Oneâyear randomized trial showed attenuation of lumbar spine BMD loss and increases in bone formation markersâmoderate-strong direct evidence.
Mood balance (3)
- Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial
PubMed ID: 19609225
12-month RCT showed a statistically significant anxiolytic signal (improved anxiety scores) though vasomotor benefit was not superior to placebo.
- Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial
PubMed ID: 41305622
Polyphenol mixture (incl. red clover) improved quality-of-life measures that include mood/health domains in equol-producers.
- Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extracts
PubMed ID: 19948385
Crossover trial showed large, clinically meaningful reductions in anxiety and depressive symptoms.
Blood circulation (2)
- Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women
PubMed ID: 12714433
Formononetinârich isoflavones decreased pulse wave velocity and total peripheral resistance â clear vascular/circulation benefit.
- The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism
PubMed ID: 11449083
Improvements in HDL and ApoB imply potential circulation/vascular benefit though study design limits certainty.
Detoxification (1)
- Precision health targeting TMAO in postmenopausal women: polyphenol effects modulated by urolithin A and equol metabotypes in a randomised, placebo-controlled crossover trial
PubMed ID: 41642121
Polyphenol mix including red clover lowered urinary TMAO and DMA â direct evidence of altered elimination of microbial metabolites (detox surrogate).
Antioxidant (1)
- Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial
PubMed ID: 41305622
Polyphenol-containing mixture including red clover produced measurable polyphenol exposure and QoL; supports possible antioxidant activity (esp. in equol-producers) but not isolated red clover data.
Urinary comfort (1)
- Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial
PubMed ID: 37836449
Small randomized trial of fermented red clover extract showed a tendency to reduce OAB symptom scores and urgency bother (modest clinical signal).
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Red Clover
Search all386 products whose verified label declares Red Clover â not every bottle that mentions it in a title.