Gotu Kola
14 benefits mapped to clinical evidence across supplements.
Dose per serving from products
198 products in our catalogue print how much Gotu Kola a serving holds.
Most common: 50 mg to 100 mg, 21% of 198 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 6 |
| 5 mg to 10 mg | 11 |
| 10 mg to 25 mg | 10 |
| 25 mg to 50 mg | 30 |
| 50 mg to 100 mg | 41 |
| 100 mg to 250 mg | 30 |
| 250 mg to 500 mg | 36 |
| 500 mg to 1 g | 34 |
Dose per serving from research
24 study groups in 16 studies say how much Gotu Kola participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg, 63% of 24 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg or less | 1 |
| 25 mg to 50 mg | 1 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 15 |
| 250 mg to 500 mg | 2 |
| 500 mg to 1 g | 1 |
| over 1 g | 1 |
Benefit Evidence
Pigment/redness improved
Hydration/elasticity +10-25%
Wrinkles/texture better
Plaque stabilization +8.8 GSM
Microcirculation/edema improved
Bleeding/thrombosis reduced
Hydration, elasticity +12%
Wrinkles, thickness, TEWL
Wound healing -6.9d
Pigment/redness improved
Hydration/elasticity +10-25%
Wrinkles/texture better
Plaque stabilization +8.8 GSM
Microcirculation/edema improved
Bleeding/thrombosis reduced
Research sources
Skin repair (9)
- Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
PubMed ID: 40613435
Panthenol mask with Centella accelerated recovery after facial laser (less erythema, pigmentation, improved TEWL) ā strong direct topical repair signal (multiāingredient).
- Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm
PubMed ID: 28248871
Highāquality RCT: topical Centella healed partialāthickness burns ~7 days faster and improved wound scores versus silver sulfadiazine.
- The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients
PubMed ID: 21298840
Large RCT: oral Centella shortened healing time (wound contraction) in diabetic woundsāoral woundāhealing support.
- Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers
PubMed ID: 34214362
Topical Centella in RCT improved skin hydration and pH ā direct barrier/repair benefit.
- The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 32310680
Splitāface RCT: Centella gel reduced postālaser erythema and improved early wound appearanceāsupports topical repair.
- Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds
PubMed ID: 38063299
Centella spray modestly improved wound scores and slightly shortened healing time for acute cleanācontaminated wounds.
- Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery
PubMed ID: 39929877
Oral nutraceutical (includes Centella) reduced early postoperative oedema and seroma after breast surgery ā benefits in early wound recovery (multiāingredient).
- Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema
PubMed ID: 26639477
Topical Centella formulations improved eczema signs (redness, swelling, itching) in large trial ā supports skin repair/antiāinflammatory effects.
- Adding herbal extracts to silicone gel on post-sternotomy scar: a prospective randomised double-blind study
PubMed ID: 32279615
Herbal extracts including Centella added to silicone gel improved scar vascularity/pigmentation ā scar repair benefit (combination product).
Skin appearance (9)
- The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color
PubMed ID: 33938432
Combination serum with Centella significantly reduced melanin and improved lightness in postāacne dark spots ā direct appearance benefit (multiāingredient).
- Adding herbal extracts to silicone gel on post-sternotomy scar: a prospective randomised double-blind study
PubMed ID: 32279615
Herbal + silicone gel improved scar vascularity/pigmentation vs silicone alone ā better scar appearance (combination product).
- Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study
PubMed ID: 37024608
Multiāherbal cream (includes Centella) improved hydration, elasticity and reduced wrinkles ā clear cosmetic improvements (multiāingredient).
- Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema
PubMed ID: 26639477
Topical Centella formulations improved erythema/oedema/itching in eczema ā visible skin improvement in a large trial.
- Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
PubMed ID: 39334942
Serums with meristem extracts including Centella improved facial elasticity and collagen marker in menopausal women ā improved appearance metrics.
- Role of Centella asiatica and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers
PubMed ID: 34214362
Topical Centella improved hydration and skin pH in workers ā contributes to healthier appearance.
- The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
PubMed ID: 32310680
Modest but significant reductions in postālaser erythema and better physicianārated wound appearance on treated side.
- A two-center randomized controlled trial of a repairing mask as an adjunctive treatment for mild to moderate rosacea
PubMed ID: 38831627
Centellaācontaining facial mask adjunct improved rosacea redness/dryness and overall lesion severity versus control.
- An Innovative Cream Improves Signs and Symptoms of Dermatoporosis in Patients Aged 65 and Over
PubMed ID: 40196951
Improved skin thickness, hydration and barrier in older adults indicates visible skin quality improvements relevant to appearance.
Blood circulation (9)
- Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model
PubMed ID: 11666124
6āmonth oral Centella improved multiple microcirculatory parameters in diabetics ā strong microcirculation evidence.
- [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]
PubMed ID: 11292962
Combination product including Centella improved chronic venous symptoms and edema but attribution to Centella alone is uncertain.
- Modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of Centella asiatica: a prospective, randomized, placebo-controlled trial
PubMed ID: 11666127
TTFCA increased femoral plaque echogenicity (plaque stabilization) ā direct vascular benefit.
- [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]
PubMed ID: 7936334
Doubleāblind trial in venous microangiopathy showing doseārelated improvements in skin microcirculation parameters after 60 days.
- Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening
PubMed ID: 21314440
Combination oral vasoactive regimen (including Centella) preserved retinal sensitivity in diabetic CMEāsuggests vascular support though multiāingredient.
- Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial
PubMed ID: 27815700
Venoplant (diosmin + Centella + others) reduced postoperative bleeding/thrombosis ā circulation benefit though multiācomponent.
- Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry
PubMed ID: 11666123
Sixāweek oral Centella RCT in venous hypertension produced objective improvements in blood flow and reduced leg volumeāstrong circulation evidence.
- Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial
PubMed ID: 11666117
Oral Centella reduced resting flux, rate of ankle swelling and capillary filtration ā clear symptomārelief support for tired/edematous legs.
- Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial
PubMed ID: 11666125
TTFCA doseāranging trial produced doseādependent reductions in capillary filtration and ankle edema in venous hypertension ā strong evidence for leg relief.
Healthy aging (4)
- An Innovative Cream Improves Signs and Symptoms of Dermatoporosis in Patients Aged 65 and Over
PubMed ID: 40196951
Centellaācontaining cream improved skin thickness, TEWL and hydration in adults ā„65ādirectly relevant to skin aging support.
- Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm
PubMed ID: 28248871
Faster burn healing and improved wound scores can support resilience of aging skin, though study population was acute burns.
- Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
PubMed ID: 39334942
Plantāmeristem serums including Centella improved elasticity, increased collagen marker and reduced lipid oxidation ā supports skin healthy aging.
- Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study
PubMed ID: 37024608
Multiāherbal cream (includes Centella) improved skin hydration/elasticity and reduced wrinkles over 60 days ā antiāaging skin effects (multiāingredient).
Joints & tendons (4)
- Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry
PubMed ID: 11666123
Improved venoarteriolar response and reduced leg volume suggest beneficial effects on microvascular connective tissue function.
- Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm
PubMed ID: 28248871
Improved burn reāepithelialization and scarārelated VSS score indicates positive effects on dermal repair and matrix remodeling.
- An Innovative Cream Improves Signs and Symptoms of Dermatoporosis in Patients Aged 65 and Over
PubMed ID: 40196951
Centellaācontaining cream increased skin thickness and improved barrier function in older adultsāevidence of connective tissue/dermal support.
- Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
PubMed ID: 39334942
Increased hydroxyproline (collagen marker) and improved elasticity with serums including Centella indicate connective tissue support (multiāingredient).
Digestive support (2)
- Comparison of Flavonoids and Centella asiatica for the treatment of chronic anal fissure. A randomized clinical trial
PubMed ID: 29844250
Randomized trial showed Centella adjunct sped bleeding cessation and earlier pain relief in anal fissureādirect symptom relief in anorectal/digestive domain.
- Comparison of Centella with Flavonoids for Treatment of Symptoms in Hemorrhoidal Disease and After Surgical Intervention: A Randomized Clinical Trial
PubMed ID: 32409760
Large trial in hemorrhoidal disease found faster reduction in anal irritation/pain with Centella adjunctārelevant to digestive/defecation comfort.
Focus & concentration (2)
- A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial
PubMed ID: 20228219
Multiāherbal preparation improved objective attention test scores in children with ADHD ā supports focus/learning (composition unclear).
- [Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy]
PubMed ID: 16729760
Psychometric and EEG improvements with multiāherb addāon (includes Centella) in hepatic encephalopathy imply improved cognitive processing relevant to learning/focus.
Wellbeing (2)
- [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]
PubMed ID: 11292962
Combination product including Centella improved clinical symptoms in chronic venous insufficiencyālikely improved patientāreported wellābeing though Centella attribution uncertain.
- Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm
PubMed ID: 28248871
Faster burn healing and better wound scores plausibly improve patient wellābeing and recovery experience.
Antioxidant (1)
- Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
PubMed ID: 39334942
Serums including Centella reduced skin lipid oxidation (MDA) in menopausal women ā direct antioxidant marker improvement (multiāingredient).
Mental clarity (1)
- [Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy]
PubMed ID: 16729760
Multiāherb addāon (includes Centella) improved clinical/psychometric measures in hepatic encephalopathy ā supports improved mental clarity (moderate attribution due to multiāherb).
Joint comfort (1)
- [Efficacy observation on acupuncture and moxibustion combined with hot compress of TCM herbs for scleroderma]
PubMed ID: 23885611
Study of localized scleroderma reported improved joint pain/function but both groups received Centella, so effect is plausible but confounded.
Mood balance (1)
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects
PubMed ID: 11106141
Single oral dose reduced acoustic startle reflex (anxiolytic marker) ā supports mood/anxiety modulation acutely.
Relaxation (1)
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects
PubMed ID: 11106141
Single oral dose of Gotu Kola reduced acoustic startle reflex amplitude in healthy volunteers ā acute anxiolytic/calm marker evidence.
Stress resilience (1)
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects
PubMed ID: 11106141
Attenuation of startle reflex after single Gotu Kola dose suggests reduced physiological stress reactivity (acute effect).
Similar by evidence
Supplements the same benefits carry qualifying findings for ā a fact about the evidence graph, not a recommendation to swap.
Products with Gotu Kola
Search all556 products whose verified label declares Gotu Kola ā not every bottle that mentions it in a title.