DIM
5 benefits mapped to clinical evidence across supplements.
Dose per serving from products
445 products in our catalogue print how much DIM a serving holds.
Most common: 50 mg to 100 mg, 34% of 445 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 12 |
| 10 mg to 25 mg | 23 |
| 25 mg to 50 mg | 54 |
| 50 mg to 100 mg | 151 |
| 100 mg to 250 mg | 133 |
| 250 mg to 500 mg | 68 |
| over 500 mg | 4 |
Dose per serving from research
11 study groups in 5 studies say how much DIM participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 mg to 250 mg and 250 mg to 500 mg, 36% of 11 study groups each.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 2 |
| 100 mg to 250 mg | 4 |
| 250 mg to 500 mg | 4 |
Benefit Evidence
Research sources
Hormone balance (2)
- Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy
PubMed ID: 26313229
Placebo‑controlled preprostatectomy trial: oral BR‑DIM altered urinary 2/16 estrogen metabolite ratio (significant at 400 mg), providing clinical support for DIM's effect on estrogen metabolism.
- A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen
PubMed ID: 28560655
High‑quality randomized human data: DIM markedly increased the urinary 2‑hydroxyestrone/16α‑hydroxyestrone ratio and raised SHBG—direct evidence for shifting estrogen metabolism.
Weight management (1)
- Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women
PubMed ID: 36111381
Randomized, placebo‑controlled trial in premenopausal women (n=60) reported a statistically significant reduction in body fat percentage with 75 mg/day DIM over 30 days—direct human evidence but small and short duration.
Urinary comfort (1)
- Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy
PubMed ID: 26313229
Preprostatectomy BR‑DIM trial measured tissue/plasma DIM and hormone‑related urinary metabolites; limited tissue accumulation but biologic activity suggests potential relevance to prostate health though clinical benefit not demonstrated.
Mood balance (1)
- The placebo effect on depressive symptoms and brain age in patients with depression: a reanalysis study of a randomized controlled clinical trial on the antidepressive effect of bright light therapy
PubMed ID: 41544307
Both bright and dim red light groups showed clinically meaningful reductions in depressive symptoms—direct mood benefit (not DIM).
Wellbeing (1)
- The placebo effect on depressive symptoms and brain age in patients with depression: a reanalysis study of a randomized controlled clinical trial on the antidepressive effect of bright light therapy
PubMed ID: 41544307
Both light interventions produced clinical improvement in depressive symptoms and reductions in brain-age metrics, suggesting broader wellness effects (not DIM).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with DIM
Search all659 products whose verified label declares DIM — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.