Valerian
7 benefits mapped to clinical evidence across supplements.
Dose per serving from products
361 products in our catalogue print how much Valerian a serving holds.
Most common: 250 mg to 500 mg, 18% of 361 products.
| Dose per serving | Products |
|---|---|
| 2.5 mg or less | 5 |
| 2.5 mg to 5 mg | 14 |
| 5 mg to 10 mg | 4 |
| 10 mg to 25 mg | 26 |
| 25 mg to 50 mg | 61 |
| 50 mg to 100 mg | 46 |
| 100 mg to 250 mg | 64 |
| 250 mg to 500 mg | 65 |
| 500 mg to 1 g | 49 |
| 1 g to 2.5 g | 27 |
Dose per serving from research
22 study groups in 21 studies say how much Valerian participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 36% of 22 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 1 |
| 100 mg to 250 mg | 3 |
| 250 mg to 500 mg | 6 |
| 500 mg to 1 g | 8 |
| 1 g to 2.5 g | 4 |
Commonly used together
8 of 22 study groups took Valerian with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Hops | 4 |
Benefit Evidence
Research sources
Sleep quality (19)
- Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study
PubMed ID: 12568976
Large multicenter trial: 600 mg/day valerian produced clinically meaningful sleep-quality improvements vs active comparator.
- The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5)
PubMed ID: 21399726
Large cancer RCT: primary PSQI AUC negative, but secondary/week‑4 measures showed increased sleep with valerian.
- Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial
PubMed ID: 21775910
Triple‑blind RCT (n=100) reported a clinically meaningful increase in proportion with improved PSQI sleep quality vs placebo.
- The effectiveness of valerian acupressure on the sleep of ICU patients: a randomized clinical trial
PubMed ID: 22391336
ICU study explicitly reported decreased night wake frequency after 'valerian acupressure' intervention.
- Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 28478716
Randomized trial in patients starting efavirenz showed significant improvements in sleep and anxiety with nightly valerian.
- Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial
PubMed ID: 30632220
EEG connectivity changes correlated with anxiolysis, implying decreased cognitive agitation even if self‑reported anxiety fell in both groups.
- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
PubMed ID: 33420602
Triple‑blind RCT after CABG showed significant PSQI and objective sleep improvements with valerian.
- Valerian/lemon balm use for sleep disorders during menopause
PubMed ID: 24199972
Randomized trial in menopausal women: valerian+lemon balm significantly reduced PSQI scores vs placebo (combination product).
- The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism
PubMed ID: 15254851
Blocking caffeine‑induced EEG arousal indicates the formulation can reduce physiologic agitation.
- [Vigilance-decreasing effects of 2 plant-derived sedatives]
PubMed ID: 8657986
Large controlled study reported improved subjective sleep quality after valerian-containing remedies.
- Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial
PubMed ID: 16335333
Valerian+hops tablet produced small subjective sleep improvements in a large RCT.
- Sleep improving effects of a single dose administration of a valerian/hops fluid extract - a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms
PubMed ID: 18559301
Acute valerian+hops fluid extract increased EEG measures of deeper sleep vs placebo.
- Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial
PubMed ID: 23543804
Polyherbal (valerian+passionflower+hops) RCT performed comparably to zolpidem on sleep duration/latency (multi‑ingredient).
- A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement
PubMed ID: 37686820
Large decentralized RCT of a botanical blend higher in valerian/hops/GABA improved PROMIS sleep disturbance (multi‑ingredient).
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial
PubMed ID: 40462685
Valerian+hops increased total sleep duration and Fitbit sleep score, consistent with increased perceived/recorded sleep depth.
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
PubMed ID: 37899385
Large 8‑week RCT with objective (actigraphy/PSG) and PSQI improvements showing robust sleep‑quality gains with standardized valerian.
- Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial
PubMed ID: 38743126
Valerian (with passionflower) reduced state anxiety during dental procedures—supports utility for acute agitation, including pre‑bed.
- [Medicinal baths for treatment of generalized fibromyalgia]
PubMed ID: 10352370
Valerian baths improved patients' reported sleep and well‑being in a small randomized study.
- [Efficacy and tolerability of Baldrian versus oxazepam in non-organic and non-psychiatric insomniacs: a randomised, double-blind, clinical, comparative study]
PubMed ID: 10899744
Randomized trial found valerian improved sleep quality comparably to oxazepam.
Stress & Anxiety (12)
- Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial
PubMed ID: 38743126
Valerian (with passionflower) before molar extraction lowered state anxiety vs placebo in a triple‑blind RCT.
- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
PubMed ID: 33420602
Post‑CABG valerian improved sleep latency/duration/efficiency, suggesting reduced restlessness overnight.
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
PubMed ID: 37899385
Standardized valerian increased sleep efficiency and total sleep time, which commonly reflect reduced nocturnal restlessness.
- Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial
PubMed ID: 30632220
Valerian produced EEG connectivity changes linked to anxiolysis, consistent with easing nervous tension physiologically.
- Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 28478716
Valerian nightly significantly improved anxiety scores in people initiating efavirenz.
- The effectiveness of valerian acupressure on the sleep of ICU patients: a randomized clinical trial
PubMed ID: 22391336
Valerian acupressure in ICU reduced night wake frequency and increased total sleep time (fewer nocturnal interruptions implied).
- Does valerian improve sleepiness and symptom severity in people with restless legs syndrome?
PubMed ID: 19284179
In RLS patients who were sleepy at baseline, 800 mg valerian reduced RLS symptom severity (reduced restlessness).
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial
PubMed ID: 40462685
Valerian+hops increased nightly sleep time; increased continuity implies less restlessness (small RCT).
- A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement
PubMed ID: 37686820
Large real‑world RCT of a botanical blend higher in valerian reported reductions in anxiety and stress (multi‑ingredient).
- The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism
PubMed ID: 15254851
Valerian+hops extract reduced caffeine‑induced EEG arousal, demonstrating central calming/adenosine‑related activity.
- Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial
PubMed ID: 37039703
Crossover trial in hemodialysis patients: valerian helped sleep quality though gabapentin was superior for RLS—valerian provided modest benefit.
- Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study
PubMed ID: 29433687
Four‑day multi‑herb product including valerian reduced subjective anxiety during an acute stress test.
Relaxation (11)
- The effectiveness of valerian acupressure on the sleep of ICU patients: a randomized clinical trial
PubMed ID: 22391336
The intervention combined valerian with acupressure/aromatherapy as a bedside ritual and produced immediate relaxation and sleep benefits in ICU patients.
- Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 28478716
Significant reductions in anxiety were observed in a randomized trial with nightly valerian.
- Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial
PubMed ID: 30632220
Valerian altered EEG connectivity in ways correlated with reduced anxiety—physiologic evidence supporting relaxation.
- A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement
PubMed ID: 37686820
Large trial of a sleep‑targeted botanical blend (including valerian) improved subjective sleep and wellbeing when used as a nightly formulation.
- [Medicinal baths for treatment of generalized fibromyalgia]
PubMed ID: 10352370
Valerian added to whirl baths improved sleep and well‑being—strong link to enhancing a relaxation ritual (bath).
- Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial
PubMed ID: 21775910
Valerian extract (530 mg BID) produced notable sleep‑quality improvements in postmenopausal women, supporting pre‑bed use.
- Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial
PubMed ID: 38743126
Peri‑procedural administration lowered state anxiety, indicating acute relaxation effects in stressful settings.
- Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study
PubMed ID: 29433687
Short multi‑herb regimen reduced subjective anxiety during stress testing.
- The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism
PubMed ID: 15254851
Valerian+hops reduced EEG markers of arousal (pharmacodynamic evidence for CNS relaxation).
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
PubMed ID: 37899385
Sustained nightly dosing led to improved latency and sleep quality, consistent with efficacy when used to unwind pre‑bed.
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial
PubMed ID: 40462685
Valerian+hops nightly increased sleep time and sleep score, compatible with facilitating pre‑sleep unwinding.
Alertness (6)
- Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial
PubMed ID: 40462685
Increased nightly sleep duration without next‑day cognitive harm suggests participants could wake more refreshed.
- Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study
PubMed ID: 12568976
Large trial reported improvements on SF‑B subscales related to refreshment and psychic symptoms with valerian.
- The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5)
PubMed ID: 21399726
Valerian arm showed improved fatigue scores in cancer patients, suggesting enhanced morning alertness/less morning sleepiness.
- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
PubMed ID: 33420602
Post‑CABG improvements in sleep parameters without safety concerns suggest better morning functioning.
- [Vigilance-decreasing effects of 2 plant-derived sedatives]
PubMed ID: 8657986
Subjects reported improved subjective sleep and there was no evidence of next‑morning hangover.
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
PubMed ID: 37899385
Objective sleep improvements (more TST/efficiency) predict better morning restoration and subjective sleep quality improvements were seen.
Sleep onset (6)
- The effectiveness of valerian acupressure on the sleep of ICU patients: a randomized clinical trial
PubMed ID: 22391336
Valerian delivered as part of an acupressure/aromatherapy bedside routine produced immediate sleepiness/relaxation in ICU—supports ritualized use.
- [Medicinal baths for treatment of generalized fibromyalgia]
PubMed ID: 10352370
Valerian used in a therapeutic bath improved sleep/well‑being—strong example of integrating valerian into a bedtime ritual.
- Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
PubMed ID: 37899385
Actigraphy showed a large reduction in sleep latency (≈48 min) at Day 56 versus placebo in an 8‑week RCT with standardized valerian.
- Efficacy of Valerian Extract on Sleep Quality after Coronary Artery bypass Graft Surgery: A Triple-Blind Randomized Controlled Trial
PubMed ID: 33420602
Post‑CABG RCT reported significant decreases in sleep latency with valerian over 30 days.
- Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 28478716
Valerian improved sleep in efavirenz patients, though latency was not the primary reported metric—supports modest impact on sleep onset.
- Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial
PubMed ID: 23543804
Polyherbal (valerian+passionflower+hops) performed similarly to zolpidem for sleep latency over 2 weeks (multi‑ingredient).
Mood balance (4)
- A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement
PubMed ID: 37686820
Large botanical blend with higher valerian content improved anxiety and wellbeing in a decentralized RCT (multi‑ingredient).
- Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial
PubMed ID: 19274698
Four‑herb combo including valerian improved anxiety and depression vs placebo in an RCT, but attribution to valerian alone is limited.
- [Clinical study on compound prescription with Valerianae Jatamansi Rhizoma et Radix in treatment of generalized anxiety disorder]
PubMed ID: 29493163
Valerian‑containing prescription improved GAD symptoms and salivary cortisol similar to control over 4 weeks (compound formula).
- Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 28478716
Valerian reduced anxiety in a randomized trial; anxiety reduction contributes to mood calming.
Stress resilience (3)
- Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial
PubMed ID: 28478716
Valerian reduced anxiety in patients initiating efavirenz, relevant to stress mitigation in a clinical context.
- A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement
PubMed ID: 37686820
Large decentralized trial reported reductions in anxiety and stress for the valerian‑containing botanical formulation.
- Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study
PubMed ID: 29433687
Herbal prescription containing valerian improved anxiety and salivary cortisol similarly to control in GAD patients (compound formulation).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Valerian
Search all1027 products whose verified label declares Valerian — not every bottle that mentions it in a title.