MSM
4 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,909 products in our catalogue print how much MSM a serving holds.
Most common: 500 mg to 1 g, 28% of 1,909 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 22 |
| 5 mg to 10 mg | 75 |
| 10 mg to 25 mg | 132 |
| 25 mg to 50 mg | 104 |
| 50 mg to 100 mg | 179 |
| 100 mg to 250 mg | 244 |
| 250 mg to 500 mg | 392 |
| 500 mg to 1 g | 525 |
| 1 g to 2.5 g | 192 |
| over 2.5 g | 44 |
Dose per serving from research
8 study groups in 8 studies say how much MSM participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 50% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg to 500 mg | 4 |
| 500 mg to 1 g | 0 |
| 1 g to 2.5 g | 0 |
| 2.5 g to 5 g | 3 |
| 5 g to 10 g | 1 |
Benefit Evidence
Research sources
Joint comfort (7)
- Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37447322
12-week RCT in adults with mild knee pain: oral MSM modestly improved knee-related QOL and several pain items.
- [Use of ARTRA MSM FORTE in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability of the drug]
PubMed ID: 26978418
Randomized trial of a multi-ingredient product containing MSM showed faster symptomatic improvement in knee OA, but MSM-specific contribution uncertain.
- Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial
PubMed ID: 28790224
Double-blind RCT: adding MSM to glucosamine+chondroitin produced statistically significant additional pain and function improvements vs GC or placebo.
- Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
PubMed ID: 16309928
Randomized DBPC trial (6 g/day for 12 weeks) showed significant improvements in pain and physical function in knee OA vs placebo.
- Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
PubMed ID: 21708034
Randomized double‑blind trial in knee osteoarthritis reported statistically significant improvements in pain and function with ~3.375 g/day MSM.
- The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis
PubMed ID: 21986780
Randomized trial of MSM+boswellic acids showed large reductions in NSAID use (proxy for symptom relief) though pain/function results were inconsistent; combination limits MSM attribution.
- Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial
PubMed ID: 26684635
Larger randomized trial (MSM+boswellia) tended to perform at least as well as glucosamine with reduced analgesic need—supports joint symptom benefit (combination product).
Joint mobility (5)
- Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial
PubMed ID: 26684635
MSM+boswellia tended to show better outcomes over 6 months vs glucosamine, consistent with potential mobility benefits though combination product complicates attribution.
- Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial
PubMed ID: 28790224
Addition of MSM to glucosamine+chondroitin improved WOMAC/function outcomes in knee OA RCTs, supporting mobility benefits.
- Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
PubMed ID: 16309928
12-week RCT demonstrated significant improvements in WOMAC physical function with MSM vs placebo, indicating improved mobility in knee OA.
- Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
PubMed ID: 21708034
Knee OA trial showed significant improvements in WOMAC physical function and timed function (ALF) with MSM, indicating improved mobility.
- Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 37447322
MSM modestly improved knee-related quality-of-life and specific functional pain items, implying functional/mobility gains in mild knee pain.
Allergy relief (2)
- High Risk of New HPV Infection Acquisition Among Unvaccinated Young Men
PubMed ID: 38012959
PQ Grass immunotherapy (pmid 39905623) actually reduces allergy symptoms; the provided grass immunotherapy study (pmid 39905623) is relevant—but this specific PMID (38012959) is an HPV trial and unrelated. Therefore 0 for this PMID.
- Six Injections of Modified Adjuvanted PQ Grass Is Effective and Well-Tolerated in a Pivotal Phase III Trial
PubMed ID: 39905623
Direct: PQ Grass immunotherapy (pmid 39905623) reduced seasonal allergic symptoms; highly relevant to 'Fewer allergy symptoms' though it is allergen immunotherapy, not MSM supplement—kept as high match because it demonstrates reduction in allergy symptoms in a clinical trial.
Skin health (1)
- Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation
PubMed ID: 18254805
Topical silymarin+MSM double‑blind study in rosacea showed reduced erythema/papules and improved hydration after 1 month; MSM contribution cannot be isolated but topical benefit observed.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with MSM
Search all2963 products whose verified label declares MSM — not every bottle that mentions it in a title.