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MSM: study protocols

10 study groups say how much MSM participants took a day. These are the doses the studies gave. They are not a recommendation.

MSM: what the research found →

Dose per serving from products

1,909 products in our catalogue print how much MSM a serving holds.

Most common: 500 mg to 1 g, 28% of 1,909 products.

Dose per servingProducts
5 mg or less
22
5 mg to 10 mg
75
10 mg to 25 mg
132
25 mg to 50 mg
104
50 mg to 100 mg
179
100 mg to 250 mg
244
250 mg to 500 mg
392
500 mg to 1 g
525
1 g to 2.5 g
192
over 2.5 g
44

Dose per serving from research

8 study groups in 8 studies say how much MSM participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 50% of 8 study groups.

Daily doseStudy groups
250 mg to 500 mg
4
500 mg to 1 g
0
1 g to 2.5 g
0
2.5 g to 5 g
3
5 g to 10 g
1

Commonly used together

3 of 10 study groups took MSM with something else, but nothing that 3 or more different studies gave.

10 study groups

Study
Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
2011 · MSM · Adults with symptomatic, radiographically confirmed knee osteoarthritis
3.38 g12 weeks25
Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial
2023 · MSM consumption group · Japanese adults aged 20 years or older who were healthy and had mild knee pain
400 mg12 weeks44
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
2006 · MSM group · Men and women aged 40–76 with knee osteoarthritis pain
6 g12 weeks—
The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial
2021 · MSM group · Adults aged 18–65 with overweight or obesity (BMI ≥25 kg/m²), without the listed cardiovascular, liver, renal, thyroid, muscular disease, diabetes or cancer conditions
3 g16 weeks—
Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial
2017 · GCM · Patients with Kellgren-Lawrence grade I-II knee osteoarthritis; age and sex not specified
500 mg90 days50
Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial
2016 · MB group · People with knee arthritis; age and sex not reported
5 g60 days—
A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial
2013 · Instaflex · Men and women aged 50–75 with self-reported joint pain lasting more than 3 months
500 mg8 weeks49
Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA
2025 · MSM · Experienced runners, mean age 38 ± 6 years, 2 women and 3 men; no diagnosed chronic disease, planning to run a half marathon
500 mg30 days5
Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men
2011 · MSM · Untrained healthy young men
50 mg/kg10 days9
Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity
2012 · MSM (M) · Healthy, non-smoking, physically active young men
50 mg/kg10 days9