L-Proline
13 benefits mapped to clinical evidence across supplements.
Dose per serving from products
1,104 products in our catalogue print how much L-Proline a serving holds.
Most common: 1 g to 2.5 g, 44% of 1,104 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 48 |
| 25 mg to 50 mg | 31 |
| 50 mg to 100 mg | 117 |
| 100 mg to 250 mg | 71 |
| 250 mg to 500 mg | 71 |
| 500 mg to 1 g | 175 |
| 1 g to 2.5 g | 483 |
| 2.5 g to 5 g | 81 |
| over 5 g | 27 |
Benefit Evidence
Research sources
Joints & tendons (18)
- Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer
PubMed ID: 15681102
Immunonutrition increased local hydroxyproline deposition (a direct collagen marker) after surgery — strong mechanistic link.
- Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects
PubMed ID: 20145666
24‑week fermented milk with proline‑containing peptides reduced arterial stiffness and slightly lowered BP—implies improved vascular/heart connective tissue properties.
- [Effect of zhuhuang frost on wound hydroxy-proline level after anal operation]
PubMed ID: 12577355
Measured increase in wound hydroxyproline (a direct collagen marker) after intervention — relevant to collagen biology though the intervention was not L‑proline supplementation.
- Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac
PubMed ID: 10791619
Oxaceprol (proline‑derived) provided symptom relief in osteoarthritis comparable to diclofenac, implying beneficial effects on cartilage‑related symptoms/maintenance.
- Effects of early use of captopril on haemodynamics and short-term ventricular remodelling in acute anterior myocardial infarction
PubMed ID: 8449203
Early captopril after anterior MI limited short‑term ventricular enlargement — direct evidence that ACE inhibition reduces cardiac remodeling/fibrosis (closest available link to heart connective tissue).
- [Effect of captopril on mortality and morbidity in patients with dysfunction of the left ventricle after myocardial infarction. Results on survival and hypertrophic studies]
PubMed ID: 7910865
Large randomized captopril post‑MI trial showing improved outcomes — strong clinical evidence that ACE inhibition benefits post‑MI remodeling and cardiac structure/function.
- Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: a randomized, double-blind, placebo-controlled trial
PubMed ID: 21723554
Casein peptide trial produced meaningful reductions in central SBP and baPWV—direct evidence of improved vascular stiffness (connective tissue function).
- Arginine enhances wound healing and lymphocyte immune responses in humans
PubMed ID: 2382229
Oral arginine substantially increased hydroxyproline (marker of collagen) in wound tissue (strong indirect evidence).
- Effect of a specialized amino acid mixture on human collagen deposition
PubMed ID: 12192323
Arginine+HMB+glutamine increased wound collagen (directly measured collagen deposition).
- Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair
PubMed ID: 33439085
Oral supplement containing proline and arginine improved wound healing — consistent with stimulated collagen synthesis/repair.
- Evaluation of the efficacy and safety of oral tiludronate in Paget's disease of bone. A double-blind, multiple-dosage, placebo-controlled study
PubMed ID: 1642662
Tiludronate markedly lowered urinary hydroxyproline (a collagen breakdown marker) — strong drug‑specific evidence that collagen metabolism is affected (indirect for L‑proline supplementation).
- Left ventricular remodeling in the year after first anterior myocardial infarction: a quantitative analysis of contractile segment lengths and ventricular shape
PubMed ID: 1532970
Captopril reduced late ventricular remodelling after anterior MI — direct evidence of affecting cardiac ECM/connective tissue (moderate‑high relevance).
- Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity
PubMed ID: 20921216
Direct human data showing proline (and glycine) increases correlate with beneficial metabolic adaptation after exercise; proline is a direct collagen precursor—strongest direct link in this dataset.
- Effect of dietary nutrients on osteochondrosis lesions and cartilage properties in pigs
PubMed ID: 18447792
Animal feeding study: proline+glycine supplementation reduced osteochondrosis lesion severity in pigs—direct cartilage maintenance evidence.
- Angiotensin-converting enzyme inhibitors increase anti-fibrotic biomarkers in African Americans with left ventricular hypertrophy
PubMed ID: 33694311
Lisinopril-associated rise in Ac‑SDKP (a proline‑containing anti‑fibrotic peptide) and MMP‑1 activity suggests ACEi-mediated modulation of cardiac collagen turnover.
- Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study
PubMed ID: 28275307
Combination therapy increased hydroxyproline and collagen I/III ratio in gastric tissue—demonstrates increased collagen production/maturation in humans.
- Improvement of crow's feet lines by topical application of 1-carbamimidoyl-L-proline (CLP)
PubMed ID: 23568622
Topical proline derivative reduced crowd's‑feet wrinkle grade and surface roughness, implying improved skin elasticity/appearance locally.
- Transdermal nicotine patch enhances type I collagen synthesis in abstinent smokers
PubMed ID: 16808802
Transdermal nicotine increased type I procollagen deposition in implanted tissue—direct measure of enhanced collagen synthesis.
Bone health (8)
- Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age
PubMed ID: 1874931
Long‑term calcium supplementation reduced lumbar bone loss and lowered hydroxyproline (collagen) turnover — direct bone structure benefit.
- Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: six-month study
PubMed ID: 17896582
AKG-Ca in postmenopausal osteopenic women produced a large CTX fall and modest lumbar BMD gain (human bone-preserving effect; AKG linked to proline).
- Clinical, biochemical, hematologic, and radiographic responses in Paget's disease following intravenous pamidronate disodium: a 2-year study
PubMed ID: 8894145
Pamidronate produced strong biochemical remission (ALP and urinary hydroxyproline) and pain improvement in Paget's disease — clear evidence of altering bone turnover/structure (drug therapy, not L‑proline).
- Efficacy of ipriflavone in established osteoporosis and long-term safety
PubMed ID: 9263613
Ipriflavone raised forearm BMD, lowered urinary hydroxyproline and reduced vertebral fractures (direct bone-structure benefit).
- Long-term effect of calcium supplementation on bone loss in perimenopausal women
PubMed ID: 7942164
Three‑year calcium supplementation reduced lumbar loss and cortical thinning — robust long‑term bone structure data.
- Effect of calcium supplementation on bone loss in postmenopausal women
PubMed ID: 8421475
Daily calcium markedly slowed/stopped bone loss and reduced hydroxyproline — clear bone‑structure effect, indirect to L‑proline.
- Effects of nandrolone decanoate on bone mass in established osteoporosis
PubMed ID: 8133796
Nandrolone modestly increased spine BMD and reduced urinary hydroxyproline — direct relevance to bone structure.
- Evaluation of the efficacy and safety of oral tiludronate in Paget's disease of bone. A double-blind, multiple-dosage, placebo-controlled study
PubMed ID: 1642662
Tiludronate substantially lowered bone‑turnover markers (SAP, urinary hydroxyproline) and improved pain in Paget’s disease — strong, direct bone structure relevance (drug‑specific).
Skin repair (7)
- Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer
PubMed ID: 15681102
Perioperative immunonutrition (arginine‑containing) increased hydroxyproline and cut wound‑healing complications — strong clinical support for improved wound repair.
- Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair
PubMed ID: 33439085
RCT: specialized oral supplement (arginine+proline+micronutrients) significantly accelerated healing of hard‑to‑heal wounds — direct clinical evidence.
- Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study
PubMed ID: 28275307
Combination therapy increased collagen fiber area and maturity in gastric ulcers—relevant to tissue repair processes.
- [Effect of zhuhuang frost on wound hydroxy-proline level after anal operation]
PubMed ID: 12577355
Higher wound hydroxyproline at days 7 and 14 indicates increased collagen deposition in healing wounds; intervention was not L‑proline but is relevant to wound repair biology.
- Treatment of symptomatic oral mucositis with sodium hyaluronate and synthetic amino acid precursors of collagen in patients undergoing haematopoietic stem cell transplantation
PubMed ID: 29921408
Hyaluronic acid spray with collagen-precursor amino acids (including L-proline) reduced severity and duration of oral mucositis post–stem-cell transplant.
- Arginine enhances wound healing and lymphocyte immune responses in humans
PubMed ID: 2382229
Arginine increased collagen deposition into standardized wounds (direct wound-repair evidence).
- Effect of a specialized amino acid mixture on human collagen deposition
PubMed ID: 12192323
Specialized amino-acid supplement increased wound collagen in elderly volunteers (direct wound outcome).
Joint comfort (5)
- Oxaceprol--a randomised, placebo-controlled clinical study in osteoarthritis with a non-conventional non-steroidal anti-inflammatory drug
PubMed ID: 17417987
Oxaceprol (a proline‑derived drug) reduced exercise-related pain in knee/hip osteoarthritis — direct clinical evidence for joint symptom relief.
- Oxaceprol versus tramadol for knee osteoarthritis: A randomized controlled trial
PubMed ID: 30636830
Oxaceprol (a hydroxyproline derivative) trial in knee OA showed symptomatic benefit comparable to tramadol — moderate direct relevance to joint comfort.
- Effect of dietary nutrients on osteochondrosis lesions and cartilage properties in pigs
PubMed ID: 18447792
Pig feeding study: dietary proline+glycine reduced cartilage lesion severity, implying improved joint/cartilage health.
- Oxaceprol is as effective as diclofenac in the therapy of osteoarthritis of the knee and hip
PubMed ID: 10088941
Oxaceprol showed similar pain/function benefit to diclofenac in OA — supports joint comfort via a proline‑derived agent.
- Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac
PubMed ID: 10791619
Oxaceprol (a proline‑derived anti‑inflammatory) produced equivalent symptom relief vs diclofenac in osteoarthritis with fewer AEs → direct clinical evidence relevant to joint comfort.
Immune support (6)
- Potential Mechanisms of Improved Activity of Natural Killer Cells Induced by the Consumption of F-MRP for 8 weeks
PubMed ID: 33966345
Fermented whey product changed immune markers (NK activity, IL‑1β) and altered arginine/proline metabolism (indirect link to proline).
- Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology
PubMed ID: 30322408
Higher baseline L‑proline associated with sustained drug‑free remission in early RA on methotrexate — suggests immunomodulatory association.
- Phase I randomized, observer-blinded, placebo-controlled study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B
PubMed ID: 37236995
mRNA vaccine used proline substitutions to stabilize spike antigen and elicit neutralizing antibodies — directly links proline residues to improved immunogenicity (structural, not nutritional).
- Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease
PubMed ID: 15004324
Larger RCT of proline‑rich colostrum fraction (Colostrinin) showed functional benefits; the product has immune-modulating/PRP nature.
- Product equivalence study comparing the tolerability, pharmacokinetics, and pharmacodynamics of various human immunoglobulin-G formulations
PubMed ID: 10883413
IVIG formulation stabilized with L‑proline showed preserved IgG PK/tolerability — demonstrates L‑proline as compatible excipient in immunoglobulin products.
- Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study
PubMed ID: 38633263
Randomized TCM preparation increased anti‑RBD IgG and seroconversion; arginine/proline pathway enrichment noted.
Strength (4)
- Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer
PubMed ID: 15681102
Increased hydroxyproline deposition after immunonutrition indicates enhanced collagen (connective tissue) formation.
- Effect of dietary nutrients on osteochondrosis lesions and cartilage properties in pigs
PubMed ID: 18447792
Dietary proline+glycine in pigs reduced cartilage lesion severity—supports connective tissue integrity.
- Evaluation of the efficacy and safety of oral tiludronate in Paget's disease of bone. A double-blind, multiple-dosage, placebo-controlled study
PubMed ID: 1642662
Tiludronate markedly reduced hydroxyproline (collagen turnover) and improved bone markers — indicates strong effects on connective tissue metabolism (drug‑specific).
- Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair
PubMed ID: 33439085
Improved wound healing with arginine+proline supplement implies stronger collagenous tissue repair.
Gut health (4)
- Impact of Probiotic Formula (Lacto-5X) on Constipation: Improvements in Gastrointestinal Symptoms, Gut Microbiome, and Metabolites
PubMed ID: 40223270
Probiotic intervention reduced fecal L‑proline and improved constipation and stool metrics — direct link between L‑proline dynamics and gut symptom improvement.
- A randomized, double-blind, placebo-controlled pilot study to evaluate the efficacy and tolerability of a novel oral bioadhesive formulation for the treatment of nonerosive reflux disease-related symptoms
PubMed ID: 32804843
Randomized trial of a bioadhesive hyaluronic‑acid + amino‑acid liquid (including proline) markedly reduced reflux symptoms vs placebo, directly supporting mucosal protection/gastro‑esophageal lining integrity; product was multi‑component so the role of L‑proline specifically is uncertain.
- Treatment of symptomatic oral mucositis with sodium hyaluronate and synthetic amino acid precursors of collagen in patients undergoing haematopoietic stem cell transplantation
PubMed ID: 29921408
Hyaluronic acid spray with collagen precursor amino acids (including proline) reduced mucositis severity and duration in transplant patients—supports mucosal integrity.
- Effects of hydrotalcite combined with esomeprazole on gastric ulcer healing quality: A clinical observation study
PubMed ID: 28275307
Combination therapy increased hydroxyproline, collagen fiber area and collagen I/III ratio in gastric ulcers—direct evidence of improved gut mucosal collagen/maturity.
Skin appearance (3)
- Improvement of crow's feet lines by topical application of 1-carbamimidoyl-L-proline (CLP)
PubMed ID: 23568622
Large RCT of a topical proline derivative (1‑carbamimidoyl‑L‑proline) showed substantial, clinically rated wrinkle improvement vs placebo.
- Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
PubMed ID: 16205932
Oral orthosilicic acid produced measurable improvements in skin roughness and hair/nail brittleness (direct skin benefit, albeit not proline).
- Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair
PubMed ID: 33439085
Specialized oral supplement containing arginine and proline accelerated healing of hard‑to‑heal wounds — likely to improve skin repair/appearance.
Exercise recovery (3)
- Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support
PubMed ID: 9434700
Parenteral mixed AA after surgery reduced proteolysis and preserved plasma proline, consistent with protein‑sparing that can aid recovery (small study, not L‑proline alone).
- Association of skeletal muscle and serum metabolites with maximum power output gains in response to continuous endurance or high-intensity interval training programs: The TIMES study - A randomized controlled trial
PubMed ID: 30742692
Baseline muscle proline correlated with gains in maximal power output after training, linking proline metabolism to muscle adaptation/recovery (associative evidence).
- Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity
PubMed ID: 20921216
Best direct evidence in this dataset: exercise intervention increased plasma proline and glycine and these changes correlated with improved whole-body insulin sensitivity—directly relevant to exercise adaptation and recovery.
Stress resilience (2)
- Metabolic Effects of Healing Touch During Cervical Cancer Treatment: An Exploratory Analysis
PubMed ID: 40908656
Healing Touch intervention reduced plasma proline and altered metabolites in patients undergoing chemoradiation — metabolic change aligned with an intervention intended to reduce stress/psychophysiologic burden.
- A brief relaxation intervention reduces stress and improves surgical wound healing response: a randomised trial
PubMed ID: 21741471
A preoperative relaxation intervention lowered perceived stress and modestly increased collagen deposition in healing wounds—direct link between stress reduction and improved tissue repair.
Muscle growth (2)
- Individualized protein fortification of human milk for preterm infants: comparison of ultrafiltrated human milk protein and a bovine whey fortifier
PubMed ID: 10468001
Strongest direct biochemical evidence in the dataset: changing dietary protein source raised serum proline — supports a role in substrate availability for protein/collagen synthesis (best match in this set).
- Nitrogen balance, 3-methylhistidine excretion, and plasma amino acid profile in infants after cardiac operations for congenital heart defects: the effect of early nutritional support
PubMed ID: 9434700
Parenteral mixed amino acids preserved plasma proline and improved nitrogen balance postoperatively, supporting amino‑acid availability for protein synthesis.
Healthy aging (1)
- Improvement of crow's feet lines by topical application of 1-carbamimidoyl-L-proline (CLP)
PubMed ID: 23568622
Topical proline derivative produced marked wrinkle improvement over 8 weeks—relevant to skin ageing and tissue appearance.
Hair growth (1)
- Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
PubMed ID: 16205932
Ch‑OSA significantly reduced hair/nail brittleness (direct trial evidence for hair/nail strengthening, though not proline).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with L-Proline
Search all1533 products whose verified label declares L-Proline — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.