Kaempferol
11 benefits mapped to clinical evidence across supplements.
Benefit Evidence
β JAK/STAT, autophagy
β skin inflammation ~37%
β lung inflammation, faster recovery
β JAK/STAT, autophagy
β skin inflammation ~37%
β lung inflammation, faster recovery
Research sources
Immune support (2)
- [Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]
PubMed ID: 38597437
12-week add-on herbal treatment (contains kaempferol) in SLE reduced JAK/STAT activation and autophagy markers β immunomodulatory biochemical improvements in patients.
- Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-ΞΊB signaling pathway
PubMed ID: 34785108
Large clinical series: multi-herb formula containing kaempferol associated with faster pulmonary lesion resolution, earlier viral clearance and improved CD4+ recovery in COVID-19 β immune-recovery signal though multi-component.
Inflammation (2)
- Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-ΞΊB signaling pathway
PubMed ID: 34785108
In COVID-19 series the multi-herb formula hastened reductions in ESR and SAA β clinical anti-inflammatory signals though formula contained many constituents.
- [Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]
PubMed ID: 38597437
Herbal add-on in SLE lowered JAK/STAT signaling and inflammatory/autophagy markers β suggests anti-inflammatory/immunomodulatory effect in patients (multi-component).
Gut health (1)
- Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial
PubMed ID: 20484173
Prospective analysis: higher flavonol intake (including kaempferol) associated with lower IL-6 and markedly reduced risk of advanced/high-risk colorectal adenoma recurrence β relevant to colon health/gut wellness (observational).
Respiratory comfort (1)
- Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-ΞΊB signaling pathway
PubMed ID: 34785108
Multi-herb formula (includes kaempferol) was associated with faster resolution of pulmonary exudative lesions and earlier viral clearance in COVID-19 patients β clinically relevant respiratory benefit in humans (multi-component).
Blood circulation (1)
- Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste)
PubMed ID: 30813256
Tomato-pomace extract produced a modest reduction in platelet aggregation (ADP-induced) β relevant to blood flow and thrombotic risk.
Antioxidant (1)
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Human RCT (grape powder containing kaempferol) reduced urinary F2-isoprostanes, indicating reduced systemic oxidative stress (kaempferol part of mixture).
Healthy aging (1)
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Human RCT showing reduced systemic oxidative stress (F2-isoprostanes) and improved lipids with a kaempferol-containing grape powder β supports processes implicated in aging.
Heart health (1)
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Grape powder RCT (contains kaempferol) reduced triglycerides and LDL in women β favorable cardiovascular risk marker changes.
Metabolism (1)
- Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress
PubMed ID: 16046716
Grape powder RCT (contains kaempferol) lowered triglycerides and LDL and reduced oxidative stress β supports metabolic/risk-factor improvement.
Detoxification (1)
- [Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]
PubMed ID: 38597437
SLE clinical study showed reductions in LC3II/LC3I (autophagy marker) and JAK/STAT activation after treatment with an herbal granule containing kaempferol β direct cellular-cleanup/autophagy-relevant biomarker change.
Skin health (1)
- The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 26151244
Short randomized trial: whey plus dodder-seed extract improved skin hydration/elasticity and reduced itch in atopic dermatitis β product may contain flavonoids including kaempferol but attribution is indirect.
Similar by evidence
Supplements the same benefits carry qualifying findings for β a fact about the evidence graph, not a recommendation to swap.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet β this is what the field is asking, not what it found.