Beta-Sitosterol
11 benefits mapped to clinical evidence across supplements.
Dose per serving from products
331 products in our catalogue print how much Beta-Sitosterol a serving holds.
Most common: 250 mg to 500 mg, 30% of 331 products.
| Dose per serving | Products |
|---|---|
| 5 mg or less | 11 |
| 5 mg to 10 mg | 9 |
| 10 mg to 25 mg | 10 |
| 25 mg to 50 mg | 32 |
| 50 mg to 100 mg | 60 |
| 100 mg to 250 mg | 94 |
| 250 mg to 500 mg | 100 |
| over 500 mg | 15 |
Benefit Evidence
Research sources
Cholesterol (25)
- Efficacy, safety and effect on biomarkers related to cholesterol and lipoprotein metabolism of rosuvastatin 10 or 20 mg plus ezetimibe 10 mg vs. simvastatin 40 or 80 mg plus ezetimibe 10 mg in high-risk patients: Results of the GRAVITY randomized study
PubMed ID: 24401221
Rosuvastatin+ezetimibe reduced LDL more than comparators and reduced β-sitosterol (supports absorption-targeted LDL reduction).
- Safety and tolerability of esterified phytosterols administered in reduced-fat spread and salad dressing to healthy adult men and women
PubMed ID: 11506058
High‑dose phytosterol esters for 8 weeks produced modest improvements in cholesterol ratio and triglycerides.
- A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men
PubMed ID: 12081816
Daily soybean phytosterols produced substantial total and LDL cholesterol reductions in a randomized trial.
- Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
PubMed ID: 9630383
Sterol‑enriched margarines reduced total and LDL cholesterol 8–13% and raised circulating plant sterols.
- Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial
PubMed ID: 10593347
Stanols (3 g/day) lowered total and LDL cholesterol ~6–10% in a large RCT — robust blood‑lipid evidence.
- Safety of long-term consumption of plant sterol esters-enriched spread
PubMed ID: 12771969
One‑year plant sterol spread gave sustained LDL reductions and increased plasma plant sterols.
- Effects of a phytosterol-enriched dairy product on lipids, sterols and 8-isoprostane in hypercholesterolemic patients: a multicenter Italian study
PubMed ID: 18762410
6‑week RCT of plant sterol‑enriched fermented milk lowered LDL and total cholesterol significantly.
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
PubMed ID: 25326876
Portfolio diet including plant sterols reduced LDL‑C substantially in a large multi‑centre trial.
- Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels
PubMed ID: 12425728
Phytosterol‑enriched chocolate RCT lowered TC and LDL and increased plasma sitosterol — clear lipid‑balance effect.
- A plant food-based diet modifies the serum beta-sitosterol concentration in hyperandrogenic postmenopausal women
PubMed ID: 14652381
Plant‑based dietary intervention increased serum beta‑sitosterol and reduced total cholesterol more than control — dietary exposure linked to lipid lowering.
- Effects of a new low dose soy protein/beta-sitosterol association on plasma lipid levels and oxidation
PubMed ID: 15309453
Soy protein product with added beta‑sitosterol lowered LDL and apoB — combined formulation but supportive for lipid balance.
- Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 wk
PubMed ID: 15531661
Supplementation trial in hypercholesterolemic adults lowered TC and raised plasma sitosterol — supports lipid modulation.
- Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals
PubMed ID: 14764424
Robust RCT (2 g/day plant sterols) significantly lowered LDL, TC and apoB — strong evidence for lipid‑balance benefit.
- Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hypercholesterolaemic subjects on a high-fat diet
PubMed ID: 18979616
Short trials with 1–2 g/day plant sterol in yogurt modestly lowered cholesterol and raised plasma sitosterol — supports modest benefit.
- Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment
PubMed ID: 18846701
Long‑term adjunctive sterol consumption produced additional LDL lowering in statin users — supports lipid balance over time.
- Action of plant sterol intervention on sterol kinetics in hypercholesterolemic men with high versus low basal circulatory plant sterol concentrations
PubMed ID: 21730224
Crossover human study: 2 g/day plant sterols strongly reduced absorption indices for campesterol and β-sitosterol with compensatory increase in cholesterol synthesis (mechanistic support for LDL lowering).
- Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial
PubMed ID: 22990854
L. reuteri trial lowered LDL ~11.6% and markedly reduced plasma campesterol/sitosterol, supporting absorption-inhibition mechanism albeit not a β-sitosterol supplement trial.
- Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies
PubMed ID: 22801416
Simvastatin+ezetimibe sharply reduced circulating campesterol and sitosterol and increased synthesis markers (shows absorption blockade reduces circulating plant sterols and LDL).
- Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients
PubMed ID: 23040830
Large analysis: ezetimibe add-on substantially reduced β-sitosterol (~47%) and increased synthesis markers while improving LDL lowering (relevant to cholesterol handling).
- Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens
PubMed ID: 26228672
Plant sterol capsules added to lipid therapy produced consistent incremental LDL and total cholesterol reductions and increased plasma sitosterol (direct blood-lipid effect).
- The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant Sterols (INVEST) study
PubMed ID: 25809853
Large RCT: plant-sterol spread raised plasma sitosterol substantially and lowered LDL modestly (direct cholesterol-lowering effect).
- A positive impact on the serum lipid profile and cytokines after the consumption of a plant sterol-enriched beverage with a milk fat globule membrane: a clinical study
PubMed ID: 30206618
Randomized crossover in humans: 2 g/day plant sterols for 6 weeks produced statistically significant drops in total and LDL cholesterol and large rise in serum β‑sitosterol.
- Efficacy and Safety of Pitavastatin/Ezetimibe Fixed-Dose Combination vs. Pitavastatin: Phase III, Double-Blind, Randomized Controlled Trial
PubMed ID: 36908150
Large phase III RCT: adding ezetimibe to pitavastatin produced large LDL‑C reductions and substantial decreases in β‑sitosterol/campesterol (absorption markers) — directly relevant mechanistic evidence.
- Effects of Pemafibrate on LDL-C and Related Lipid Markers in Patients with MASLD: A Sub-Analysis of the PEMA-FL Study
PubMed ID: 39694503
MASLD trial subanalysis: pemafibrate reduced LDL‑C and lowered lathosterol and β‑sitosterol — strong human evidence of impacts on cholesterol pathways.
- Effects of Pemafibrate on Cholesterol Synthesis and Absorption: a Post-Hoc Subgroup Analysis of a Phase 2 Clinical Trial
PubMed ID: 40436796
Phase 2 pemafibrate study showed dose‑dependent LDL reductions with corresponding decreases in β‑sitosterol and lathosterol — mechanistic support for cholesterol modulation.
Heart health (13)
- Efficacy, safety and effect on biomarkers related to cholesterol and lipoprotein metabolism of rosuvastatin 10 or 20 mg plus ezetimibe 10 mg vs. simvastatin 40 or 80 mg plus ezetimibe 10 mg in high-risk patients: Results of the GRAVITY randomized study
PubMed ID: 24401221
Rosuvastatin+ezetimibe lowered LDL more than comparators and reduced β-sitosterol (clinical lipid improvement relevant to heart health).
- Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens
PubMed ID: 26228672
Well-controlled trial: adding plant sterols to lipid therapy produced additional LDL and total cholesterol reductions (direct CV risk factor improvement).
- A positive impact on the serum lipid profile and cytokines after the consumption of a plant sterol-enriched beverage with a milk fat globule membrane: a clinical study
PubMed ID: 30206618
Plant‑sterol–enriched beverage produced small but significant reductions in total and LDL cholesterol in postmenopausal women — modest implication for heart health.
- Efficacy and Safety of Pitavastatin/Ezetimibe Fixed-Dose Combination vs. Pitavastatin: Phase III, Double-Blind, Randomized Controlled Trial
PubMed ID: 36908150
Large RCT showed major LDL‑C reductions when ezetimibe was added and associated drops in β‑sitosterol (cholesterol absorption marker) — relevant to cardiovascular risk management.
- A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men
PubMed ID: 12081816
Randomized trial in young men found ~15% LDL reduction with soybean phytosterols — favorable for heart health.
- Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
PubMed ID: 9630383
Well‑controlled trial showing consistent 8–13% reductions in total and LDL cholesterol with sterol‑enriched margarines.
- Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial
PubMed ID: 10593347
Large US trial: stanol esters lowered total and LDL cholesterol ~6–10%, supporting heart‑health relevance.
- Safety of long-term consumption of plant sterol esters-enriched spread
PubMed ID: 12771969
One‑year plant sterol spread produced sustained LDL lowering and blood plant sterol rises — clinically meaningful for heart health.
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
PubMed ID: 25326876
Large multicentre dietary portfolio including plant sterols produced substantial LDL‑C reductions — cardiovascular risk relevant.
- Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals
PubMed ID: 14764424
Well-powered RCT shows 2 g/day plant sterols lower LDL/TC — surrogate for cardiovascular risk (indirect heart-health benefit).
- Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies
PubMed ID: 22801416
Simvastatin+ezetimibe markedly reduced circulating plant sterols and altered synthesis markers; relevant to absorption and LDL management (CV risk implications).
- Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients
PubMed ID: 23040830
Large analysis: ezetimibe add-on substantially lowered β-sitosterol and increased synthesis markers with greater LDL lowering when combined with potent statins (CV-relevant lipid changes).
- Effects of Pemafibrate on LDL-C and Related Lipid Markers in Patients with MASLD: A Sub-Analysis of the PEMA-FL Study
PubMed ID: 39694503
Pemafibrate trial in MASLD reduced LDL‑C and absorption/synthesis markers (including β‑sitosterol) — mechanistically relevant to heart health.
Urinary comfort (5)
- Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group
PubMed ID: 7540705
Trial showed beta‑sitosterol improved peak urinary flow (Qmax) by ~5.3 mL/s vs placebo — clear urinary flow benefit.
- Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up
PubMed ID: 10792163
Open 18‑month follow‑up of men on beta‑sitosterol showed maintained symptom improvements vs stopping — direct clinical evidence for BPH symptom relief.
- Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH)
PubMed ID: 12092634
3‑month RCT of a multi‑ingredient product including beta‑sitosterol showed improved BPH symptoms (no flow change) — benefit seen but attribution to beta‑sitosterol alone uncertain.
- A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency
PubMed ID: 32620155
12‑week double‑blind RCT of β‑sitosterol‑enriched saw palmetto product improved IPSS scores and Qmax versus placebo — strong clinical evidence for urinary/prostate symptom relief (product multi‑component).
- A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group
PubMed ID: 9313662
Multicentre RCT documented increased Qmax (~+4.5 mL/s) and decreased post‑void residual with beta‑sitosterol.
Metabolism (4)
- Effects of Pemafibrate on Cholesterol Synthesis and Absorption: a Post-Hoc Subgroup Analysis of a Phase 2 Clinical Trial
PubMed ID: 40436796
Phase 2 pemafibrate study showed dose‑dependent decreases in lathosterol and β‑sitosterol alongside LDL‑C reductions, supporting metabolic/lipid modulation.
- Effects of Pemafibrate on LDL-C and Related Lipid Markers in Patients with MASLD: A Sub-Analysis of the PEMA-FL Study
PubMed ID: 39694503
Pemafibrate reduced LDL and cholesterol absorption/synthesis markers in MASLD, indicating broader metabolic lipid effects.
- A plant food-based diet modifies the serum beta-sitosterol concentration in hyperandrogenic postmenopausal women
PubMed ID: 14652381
Plant‑based dietary program increased beta‑sitosterol and reduced total cholesterol (~14%) — broad metabolic improvement signal.
- Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study
PubMed ID: 25921846
Large prospective cohort found higher circulating plant‑sterol markers associated with lower incident T2D risk (associative evidence).
Immune support (4)
- A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis
PubMed ID: 9487449
Sitosterol‑containing adjunct in TB patients increased lymphocyte counts and was associated with greater weight gain (immunologic signals).
- [Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]
PubMed ID: 38597437
Multi‑herb add‑on trial in SLE (includes β‑sitosterol) modulated JAK/STAT signalling, implying immune effects but not attributable to β‑sitosterol alone.
- A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults
PubMed ID: 38580687
Small RCT of a Cordyceps beverage (contains β‑sitosterol) increased NK cell activity — supports immune modulation though multi‑component product.
- A randomized trial of efficacy of beta-sitosterol and its glucoside as adjuvant to cryotherapy in the treatment of anogenital warts
PubMed ID: 24838062
Sterol/sterolin mixture increased wart clearance when added to cryotherapy (clinical immune-mediated lesion clearance).
Antioxidant (3)
- Effects of a phytosterol-enriched dairy product on lipids, sterols and 8-isoprostane in hypercholesterolemic patients: a multicenter Italian study
PubMed ID: 18762410
RCT showed a significant reduction in 8‑isoprostane (oxidative stress marker) with plant‑sterol product.
- Safety of long-term consumption of plant sterol esters-enriched spread
PubMed ID: 12771969
One‑year plant sterol RCT reported decreases in circulating carotenoids (antioxidant markers), showing impact on antioxidant status.
- Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations
PubMed ID: 11755939
Plant stanol yoghurt altered lipid‑standardized fat‑soluble antioxidant levels, indicating antioxidant‑related changes.
Inflammation (3)
- [Jianpi Zishen granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]
PubMed ID: 38597437
Herbal formula (including β‑sitosterol) reduced JAK/STAT activation and autophagy markers in SLE patients — indicates anti‑inflammatory biochemical effects.
- A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults
PubMed ID: 38580687
Cordyceps beverage reduced pro‑inflammatory cytokines (TNF‑α, IL‑1β) in a small human trial; β‑sitosterol was one of several constituents.
- Effects of a phytosterol-enriched dairy product on lipids, sterols and 8-isoprostane in hypercholesterolemic patients: a multicenter Italian study
PubMed ID: 18762410
Plant‑sterol enriched product reduced 8‑isoprostane (oxidative/inflammatory marker) in an RCT.
Blood circulation (1)
- Consumption of a dietary portfolio of cholesterol lowering foods improves blood lipids without affecting concentrations of fat soluble compounds
PubMed ID: 25326876
Portfolio diet including plant sterols substantially lowered LDL — beneficial for vascular/circulatory risk profile.
Skin health (1)
- Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Cancer
PubMed ID: 29889137
Phase III RCT: topical β-sitosterol-containing ointment significantly reduced severe pruritus and severe local pain during breast radiotherapy (clear symptomatic skin benefit).
Vitality (1)
- A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis
PubMed ID: 9487449
TB patients receiving sitosterol adjunct gained more weight and had higher lymphocyte counts, suggesting improved clinical recovery/vitality.
Weight management (1)
- A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis
PubMed ID: 9487449
Sitosterol‑containing supplement as adjunct in TB treatment was associated with greater weight gain vs placebo.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Beta-Sitosterol
Search all516 products whose verified label declares Beta-Sitosterol — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.