Sulforaphane
14 benefits mapped to clinical evidence across supplements.
Dose per serving from products
49 products in our catalogue print how much Sulforaphane a serving holds.
Most common: 250 mcg to 500 mcg, 16% of 49 products.
| Dose per serving | Products |
|---|---|
| 50 mcg or less | 2 |
| 50 mcg to 100 mcg | 2 |
| 100 mcg to 250 mcg | 6 |
| 250 mcg to 500 mcg | 8 |
| 500 mcg to 1 mg | 6 |
| 1 mg to 2.5 mg | 5 |
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 7 |
| 25 mg to 50 mg | 3 |
| 50 mg to 100 mg | 4 |
| 100 mg to 250 mg | 1 |
| over 250 mg | 2 |
Dose per serving from research
16 study groups in 10 studies say how much Sulforaphane participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg and 50 mg to 100 mg, 31% of 16 study groups each.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 2 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 5 |
| 50 mg to 100 mg | 5 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 0 |
| 500 mg to 1 g | 3 |
| over 1 g | 1 |
Benefit Evidence
Cognition + working memory
ASD/ADHD symptoms -34%
Schizophrenia negative symptoms d≈0.8
Clearer processing (+p<0.05)
Behavior improved (−34%)
ADHD symptoms improved (d>1.0)
Lower HOMA-IR, glucose
GLP-1/gut bacteria +SCFAs
Fasting glucose -0.2 mmol/L
Gastric inflammation ↓; H. pylori
IL-6/TNF-α ↓; inflammation
MDA ↓; gastric inflammation
Cognition + working memory
ASD/ADHD symptoms -34%
Schizophrenia negative symptoms d≈0.8
Clearer processing (+p<0.05)
Behavior improved (−34%)
ADHD symptoms improved (d>1.0)
Gastric inflammation ↓; H. pylori
IL-6/TNF-α ↓; inflammation
MDA ↓; gastric inflammation
Research sources
Brain health (10)
- Sulforaphane treatment of autism spectrum disorder (ASD)
PubMed ID: 25313065
Robust randomized, double‑blind placebo‑controlled trial showed large, clinically meaningful behavioral improvements in young men with autism.
- Effects of sulforaphane on negative symptoms and cognitive impairments in chronic schizophrenia patients: A randomized double-blind trial
PubMed ID: 40133020
Replicated benefit on negative symptoms in chronic schizophrenia supports reproducible brain/behavioral effects.
- Efficacy and Safety of Sulforaphane Added to Antipsychotics for the Treatment of Negative Symptoms of Schizophrenia: A Randomized Controlled Trial
PubMed ID: 39832347
Double-blind RCT showed substantial reduction in negative symptoms of schizophrenia—strong clinical evidence for a CNS-related therapeutic effect.
- Efficacy and Safety of Altibrain(®) as an Adjunctive Therapy for Autism Spectrum Disorder: An Open Label Trial Targeting Core Symptoms
PubMed ID: 39865822
Large open-label improvements in autism core symptoms and adaptive behavior suggest potential brain/behavioral benefits, though study design limits certainty.
- Sulforaphane Adjunct to Methylphenidate for Attention-deficit/Hyperactivity Disorder: A Randomized, Double-blind, Placebo-controlled Trial
PubMed ID: 41604557
Marked improvements in ADHD core symptoms indicate robust functional brain benefits (attention/hyperactivity domains).
- Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial
PubMed ID: 33503851
Cognitive improvements in older adults indicate direct brain‑supporting effects.
- Efficacy of Sulforaphane in Treatment of Children with Autism Spectrum Disorder: A Randomized Double-Blind Placebo-Controlled Multi-center Trial
PubMed ID: 36427174
Multicenter ASD RCT produced clinician‑rated improvement, supporting potential brain effects despite inconsistent caregiver ratings.
- Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 34033171
Antidepressant effects in post‑cardiac patients indicate mood/brain benefits.
- Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 32347624
Adjunct trial in ASD showed behavioral symptom improvement, supporting brain/behavior modulation.
- Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
PubMed ID: 34034808
Randomized ASD trial with objective biomarker improvements and behavioral gains supports SFN neurobiological effects.
Cell health (9)
- Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention-results from the Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) randomized controlled trial
PubMed ID: 30982861
Year‑long high‑glucoraphanin intervention attenuated pro‑oncogenic transcriptional drift in prostate tissue (protective transcriptional effects).
- Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects
PubMed ID: 26604653
Reduced oxidative DNA damage (8‑OHdG) in men with fatty‑liver features indicates cellular DNA protection.
- Accumulation of Sulforaphane and Alliin in Human Prostate Tissue
PubMed ID: 36014767
Direct detection of SFN in human prostate tissue supports potential local cytoprotective actions.
- Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China
PubMed ID: 24913818
Large trial showed enhanced detoxication of benzene and acrolein, reducing cellular exposure to reactive toxicants.
- Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial
PubMed ID: 31155953
Systemic SFN uptake with downregulation of certain cancer‑associated prostate transcripts suggests cellular protective signaling.
- Effect of Sulforaphane in Men with Biochemical Recurrence after Radical Prostatectomy
PubMed ID: 25968598
Stabilized free SFN produced favorable secondary PSA kinetics and longer PSA doubling time in biochemical recurrence, implying possible tumor‑protective effects.
- Sulforaphane Bioavailability and Chemopreventive Activity in Women Scheduled for Breast Biopsy
PubMed ID: 26511489
SFN exposure was associated with reduced PBMC HDAC activity, indicating epigenetic and signalling modulation.
- Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies
PubMed ID: 26329135
Observational association of higher cruciferous intake with lower Ki‑67 in DCIS suggests lower cellular proliferation.
- Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer
PubMed ID: 40041932
Randomized trial showed significant reduction in bronchial Ki-67 proliferation index—strong biomarker evidence for cellular protection/chemoprevention in airway epithelium.
Detoxification (5)
- Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
PubMed ID: 16284385
Individual‑level inverse associations between SFN metabolites and aflatoxin‑DNA adducts/phenanthrene tetraol indicate enhanced detoxication capacity.
- Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China
PubMed ID: 24913818
Large randomized trial showed rapid, durable increases in urinary detoxication products of benzene and acrolein after broccoli‑sprout beverage consumption.
- Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China
PubMed ID: 31268126
Dose‑dependent, clinically significant increase (+63%) in urinary benzene mercapturic acid (SPMA) — strong evidence of enhanced benzene detoxication.
- Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
PubMed ID: 22045030
Confirmed earlier: increased urinary mercapturic acids of common airborne pollutants, directly supporting detoxification (duplicate emphasis).
- Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects
PubMed ID: 26604653
Lowered oxidative DNA damage and improved liver enzymes in fatty‑liver features indicate improved handling of metabolic/toxic stressors.
Mental clarity (4)
- Sulforaphane Adjunct to Methylphenidate for Attention-deficit/Hyperactivity Disorder: A Randomized, Double-blind, Placebo-controlled Trial
PubMed ID: 41604557
Adjunctive SFN produced large improvements in ADHD inattention scores—direct evidence for improved attention/concentration relevant to cognitive clarity.
- Sulforaphane treatment of autism spectrum disorder (ASD)
PubMed ID: 25313065
Randomized double‑blind trial in young men with autism produced substantial improvements on validated behavioral scales, relevant to cognitive/behavioral function.
- Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
PubMed ID: 34034808
ASD RCT found behavioral and biomarker changes that correlated with cognitive/behavioral improvement on caregiver‑rated scales.
- Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial
PubMed ID: 33503851
12‑week RCT in older adults showed modest improvements in processing speed and working memory with SFN.
Blood sugar (3)
- Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
PubMed ID: 39929977
Randomized trial showed modest but statistically significant lowering of fasting glucose overall and larger effects in a microbiome-defined prediabetes subgroup—direct evidence for glycaemic benefit.
- Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial
PubMed ID: 22537070
Randomized trial in type 2 diabetes showed modest but significant decreases in fasting insulin and HOMA‑IR after 4 weeks of broccoli sprout powder.
- Improving insulin resistance by sulforaphane via activating the Bacteroides and Lactobacillus SCFAs-GPR-GLP1 signal axis
PubMed ID: 39045769
Human NAFLD arm showed increased GLP‑1 and correlated reductions in blood glucose and HOMA‑IR — direct glucose‑metabolism benefit.
Metabolism (3)
- Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial
PubMed ID: 22537070
Type 2 diabetes RCT demonstrated modest improvements in insulin resistance (HOMA‑IR), supporting metabolic effects.
- Improving insulin resistance by sulforaphane via activating the Bacteroides and Lactobacillus SCFAs-GPR-GLP1 signal axis
PubMed ID: 39045769
SFN linked to improved insulin sensitivity, gut microbiota shifts and increased GLP‑1 in NAFLD patients indicating metabolic benefits.
- Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
PubMed ID: 39929977
Randomized evidence of modest fasting glucose lowering and microbiome-dependent metabolic effects supports a role in metabolic balance.
Inflammation (3)
- Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
PubMed ID: 19349290
8‑week sulforaphane‑rich sprout consumption reduced gastric inflammation biomarkers alongside reductions in H. pylori.
- The Effects of Broccoli Sprout Extract Containing Sulforaphane on Lipid Peroxidation and Helicobacter pylori Infection in the Gastric Mucosa
PubMed ID: 25287166
BSES reduced gastric mucosal MDA (oxidative damage) which is linked to local inflammatory status, though H. pylori colonization was unchanged.
- Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
PubMed ID: 34034808
RCT in ASD demonstrated decreased inflammatory cytokine expression (IL‑6, TNF‑α) and improved redox/mitochondrial markers.
Antioxidant (2)
- The Effects of Broccoli Sprout Extract Containing Sulforaphane on Lipid Peroxidation and Helicobacter pylori Infection in the Gastric Mucosa
PubMed ID: 25287166
4‑week broccoli‑sprout supplement significantly reduced gastric mucosal MDA (lipid peroxidation), a local oxidative‑damage marker.
- Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects
PubMed ID: 26604653
Randomized trial showed significant reduction in urinary 8‑OHdG (oxidative DNA damage) and modest liver enzyme improvements, indicating antioxidant effect.
Gut health (2)
- Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
PubMed ID: 19349290
8‑week broccoli‑sprout intake reduced H. pylori levels and serum pepsinogen markers, indicating improved gastric mucosal health.
- The Effects of Broccoli Sprout Extract Containing Sulforaphane on Lipid Peroxidation and Helicobacter pylori Infection in the Gastric Mucosa
PubMed ID: 25287166
Four weeks of BSES lowered gastric mucosal lipid peroxidation (MDA), supporting mucosal barrier protection even without eradication of H. pylori.
Immune support (2)
- Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder
PubMed ID: 34034808
RCT in ASD showed decreased IL‑6/TNF‑α expression and other immune biomarker improvements.
- Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans
PubMed ID: 19349290
8‑week sulforaphane‑rich sprout consumption reduced H. pylori levels and gastric inflammatory markers, indicating local immune/antimicrobial effects.
Heart health (1)
- Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials
PubMed ID: 25851421
Twelve weeks of high‑glucoraphanin broccoli led to a statistically greater reduction in plasma LDL cholesterol vs standard broccoli.
Stress resilience (1)
- Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 34033171
Randomized trial showed clinically meaningful improvements in depressive symptoms—relevant to psychological stress resilience.
Respiratory comfort (1)
- The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis
PubMed ID: 33920642
BSE improved objective nasal airflow (PNIF) after allergen challenge, especially with intranasal steroid.
Joint comfort (1)
- Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint
PubMed ID: 28611391
High‑glucoraphanin broccoli raised ITCs in synovial fluid and altered joint proteome in knee OA patients (biological plausibility for joint effects).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Sulforaphane
Search all55 products whose verified label declares Sulforaphane — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.