Neem
13 benefits mapped to clinical evidence across supplements.
Dose per serving from products
47 products in our catalogue print how much Neem a serving holds.
Most common: 500 mg to 1 g, 34% of 47 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 3 |
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 4 |
| 100 mg to 250 mg | 4 |
| 250 mg to 500 mg | 15 |
| 500 mg to 1 g | 16 |
| over 1 g | 1 |
Benefit Evidence
Plaque/gingivitis ↓ 6-26%
Bacteria/inflammation improved
Caries reversal, pain ↓
Plaque/gingivitis ↓ 6-26%
Bacteria/inflammation improved
Caries reversal, pain ↓
Research sources
Oral health (9)
- Comparative Evaluation of Neem Mouthwash on Plaque and Gingivitis: A Double-blind Crossover Study
PubMed ID: 28713109
Neem mouthwash modestly but significantly lowered gingival index within groups, comparable to chlorhexidine for gingival inflammation.
- The effects of a novel herbal toothpaste on salivary lactate dehydrogenase as a measure of cellular integrity
PubMed ID: 33064207
Multi-herbal toothpaste (contains neem) reduced gingival index and biomarkers vs fluoride control (cannot isolate neem effect).
- A randomized clinical study to examine the oral hygiene efficacy of a novel herbal toothpaste with zinc over a 6-month period
PubMed ID: 33866666
6-month herbal+zinc toothpaste including neem produced large improvements in gingival index and bleeding vs fluoride (multi-ingredient but strong clinical effect).
- Comparison of the effectiveness of 0.5% tea, 2% neem and 0.2% chlorhexidine mouthwashes on oral health: a randomized control trial
PubMed ID: 23852229
2% neem mouthwash improved gingival index and raised salivary pH (small trial; tea performed better for plaque).
- The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study
PubMed ID: 15335093
Six-week neem dental gel significantly lowered plaque and gingivitis, comparable to chlorhexidine gel (direct gum health evidence).
- Effect of Neem containing Toothpaste on Plaque and Gingivitis--A Randomized Double Blind Clinical Trial
PubMed ID: 26718296
Small double-blind trial: neem toothpaste improved gingival index vs control (supports gum-health benefit).
- Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial
PubMed ID: 29208784
Neem mouthwash reduced gingival index and plaque in orthodontic patients, comparable to chlorhexidine in clinical measures.
- Anti-plaque Efficacy of Herbal Mouthwashes Compared to Synthetic Mouthwashes in Patients Undergoing Orthodontic Treatment: A Randomised Controlled Trial
PubMed ID: 30151504
Short orthodontic trial: neem-containing mouthwash reduced plaque and had some gingival benefits though not the top product tested.
- Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post-operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial
PubMed ID: 33884661
Neem irrigant reduced endotoxin more than NaOCl and transiently lowered postoperative pain; supports endodontic hygiene/cleaning.
Gut health (6)
- The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study
PubMed ID: 15335093
Six-week neem dental gel lowered plaque and gingivitis comparably to chlorhexidine (antimicrobial/antiplaque benefits).
- Antimicrobial efficacy of various disinfecting solutions in reducing the contamination of the toothbrush -- a comparative study
PubMed ID: 19583039
Soaking toothbrushes in 3% neem produced ~86% reduction in S. mutans contamination (robust disinfectant effect on fomites).
- Effect of Neem containing Toothpaste on Plaque and Gingivitis--A Randomized Double Blind Clinical Trial
PubMed ID: 26718296
Small double-blind trial: neem-containing toothpaste significantly improved plaque and gingival indices vs control (antiplaque effect).
- Comparative Evaluation of Neem Mouthwash on Plaque and Gingivitis: A Double-blind Crossover Study
PubMed ID: 28713109
Neem mouthwash modestly lowered gum inflammation and slightly reduced plaque; shows some antimicrobial/antiplaque activity.
- Impact of Mouthwashes on Antibacterial Activity of Subjects with Fixed Orthodontic Appliances: A Randomized Clinical Trial
PubMed ID: 29208784
Neem mouthwash lowered plaque, gingival inflammation and S. mutans counts in orthodontic patients (clinically relevant antibacterial effect).
- Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post-operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial
PubMed ID: 33884661
Root-canal irrigant with neem reduced endotoxin more than NaOCl and modestly reduced early post-op pain; meaningful antimicrobial/endotoxin effects.
Scalp health (2)
- Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study
PubMed ID: 31756189
Neem+coconut oil treatment reduced lesion severity, pain and itching from embedded sand fleas affecting skin/scalp-adjacent areas; relevant to local scalp/skin health.
- Randomized, investigator-blinded, controlled clinical study with lice shampoo (Licener®) versus dimethicone (Jacutin® Pedicul Fluid) for the treatment of infestations with head lice
PubMed ID: 28488042
Neem-containing lice shampoo cured nearly all infestations and had strong ovicidal efficacy with good tolerability — direct scalp health benefit.
Skin soothing (2)
- Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study
PubMed ID: 31756189
Duplicate: strong itch relief seen in tungiasis trial (included above).
- Randomized, investigator-blinded, controlled clinical study with lice shampoo (Licener®) versus dimethicone (Jacutin® Pedicul Fluid) for the treatment of infestations with head lice
PubMed ID: 28488042
Effective lice shampoo cures infestation, which often relieves associated itching (direct practical benefit).
Pain relief (2)
- Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study
PubMed ID: 31756189
Neem+coconut markedly reduced pain and itching and decreased acute pathology in tungiasis patients (strong symptomatic relief).
- Hypericum and neem oil for dehisced post-surgical wounds: a randomised, controlled, single-blinded phase III study
PubMed ID: 35678785
Hypericum+neem dressing significantly reduced wound pain versus silver dressings (not attributable solely to neem but clinically meaningful pain relief).
Skin repair (2)
- Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study
PubMed ID: 31756189
Neem+coconut improved lesion severity and accelerated parasite aging in tungiasis, aiding local skin recovery and symptom resolution.
- Hypericum and neem oil for dehisced post-surgical wounds: a randomised, controlled, single-blinded phase III study
PubMed ID: 35678785
Hypericum+neem dressing significantly reduced wound pain but did not change inflammatory wound signs vs silver; modest support for symptomatic recovery.
Immune support (1)
- Neem (Azadirachta Indica A. Juss) Capsules for Prophylaxis of COVID-19 Infection: A Pilot, Double-Blind, Randomized Controlled Trial
PubMed ID: 33891569
Pilot RCT of neem capsules showed ~55% lower COVID-19 incidence (preliminary evidence of immune-related protection).
Stress & Anxiety (1)
- Hypericum and neem oil for dehisced post-surgical wounds: a randomised, controlled, single-blinded phase III study
PubMed ID: 35678785
Dressings containing hypericum+neem reduced wound pain substantially (calming/comforting effect on patients).
Skin appearance (1)
- Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study
PubMed ID: 31756189
Neem+coconut treatment reduced lesion severity and pathology from embedded sand fleas (improved skin appearance/function in that condition).
Antioxidant (1)
- Aqueous Azadirachta indica (Neem) Extract Attenuates Insulin Resistance to Improve Glycemic Control and Endothelial Function in Subjects with Metabolic Syndrome
PubMed ID: 34582720
Study in metabolic syndrome reported reduced oxidative stress markers alongside metabolic improvements, supporting antioxidant effects.
Blood circulation (1)
- Aqueous Azadirachta indica (Neem) Extract Attenuates Insulin Resistance to Improve Glycemic Control and Endothelial Function in Subjects with Metabolic Syndrome
PubMed ID: 34582720
Same metabolic-syndrome trial reported improved endothelial (vascular) function alongside metabolic improvements.
Metabolism (1)
- Aqueous Azadirachta indica (Neem) Extract Attenuates Insulin Resistance to Improve Glycemic Control and Endothelial Function in Subjects with Metabolic Syndrome
PubMed ID: 34582720
Aqueous neem extract in people with metabolic syndrome improved glycemic control, insulin resistance and related markers dose-dependently.
Wellbeing (1)
- Aqueous Azadirachta indica (Neem) Extract Attenuates Insulin Resistance to Improve Glycemic Control and Endothelial Function in Subjects with Metabolic Syndrome
PubMed ID: 34582720
Improvements in metabolic syndrome markers suggest broader health/wellness benefits in that population.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Neem
Search all161 products whose verified label declares Neem — not every bottle that mentions it in a title.