Aloe Vera
12 benefits mapped to clinical evidence across supplements.
Dose per serving from products
520 products in our catalogue print how much Aloe Vera a serving holds.
Most common: 25 mg to 50 mg, 23% of 520 products.
| Dose per serving | Products |
|---|---|
| 500 mcg or less | 2 |
| 500 mcg to 1 mg | 27 |
| 1 mg to 2.5 mg | 12 |
| 2.5 mg to 5 mg | 17 |
| 5 mg to 10 mg | 51 |
| 10 mg to 25 mg | 39 |
| 25 mg to 50 mg | 122 |
| 50 mg to 100 mg | 87 |
| 100 mg to 250 mg | 91 |
| 250 mg to 500 mg | 40 |
| 500 mg to 1 g | 18 |
| over 1 g | 14 |
Dose per serving from research
6 study groups in 5 studies say how much Aloe Vera participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 50% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 0 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 2 |
| 500 mg to 1 g | 3 |
Benefit Evidence
Research sources
Skin soothing (40)
- [Antiinflammatory potential of seven plant extracts in the ultraviolet erythema test. A randomized, placebo-controlled study]
PubMed ID: 23337964
Randomized human trial: Aloe gel significantly reduced UVāinduced skin erythema versus control.
- Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial
PubMed ID: 26742306
Aloe syrup reduced frequency of GERD symptoms, indicating calming of esophageal/gastric irritation in a pilot RCT.
- Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds
PubMed ID: 26488737
Aloeāolive oil cream improved chronic wound healing and reduced pain vs active comparator in humans (direct soothing/skin benefit).
- Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
PubMed ID: 28088806
Oral Aloe sterol supplementation improved skin hydration and elasticity in healthy women (objective skin benefit suggesting soothing effect).
- Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study
PubMed ID: 27314762
Systemic and topical Aloe improved burning sensation and function in oral submucous fibrosis (reduction of mucosal irritation/discomfort).
- The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women
PubMed ID: 28521546
Topical Aloe reduced itching and erythema and slowed progression of stretch marks in pregnant women (clinical soothing/antiāitch effect).
- The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial
PubMed ID: 30268162
Topical Aloe reduced early pressureāulcer incidence, local temperature and pain in orthopedic inpatients ā strong topical soothing/preventive effect.
- Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial
PubMed ID: 31664632
Aloe gel strongly reduced traumatic oral ulcers with a large protective effect ā calms/limits mucosal irritation.
- Aloe Vera; A new treatment for atrophic vaginitis, A randomized double-blinded controlled trial
PubMed ID: 33383112
Topical Aloe vaginal cream improved vaginal health indices and symptoms of atrophic vaginitis nearly as well as estrogen ā calms local irritation/dryness.
- Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients
PubMed ID: 32404169
Topical 3% Aloe during pelvic RT markedly reduced acute radiation proctitis symptoms and systemic CRP ā strong antiāirritant/antiāinflammatory signal.
- Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial
PubMed ID: 32515040
Oral Aloe sterols improved skin barrier and hydration (TEWL, collagen) ā supports skin comfort and reduced dryness.
- Comparative efficacy of topical aloe vera and low-level laser therapy in the management of oral lichen planus: a randomized clinical trial
PubMed ID: 34853932
Topical Aloe reduced pain and lesion activity in oral lichen planus (less effective than LLLT) ā some antiāirritant benefit.
- A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial
PubMed ID: 33576219
Topical aloe gel reduced burning pain in oral submucous fibrosis more than curcumin gelāconsistent with calming mucosal irritation.
- A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
PubMed ID: 33811776
Aloeācontaining adsorbent lotion produced significantly greater itch reduction vs hydrocortisone for intertrigoāstrong evidence for antiāpruritic effect.
- Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study
PubMed ID: 34967575
Combination topical (black turmeric + aloe) produced substantially greater reduction in burning sensation vs steroid regimen in oral submucous fibrosis (multiāingredient).
- Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study
PubMed ID: 33832645
Vaginal gel containing aloe reduced VVA symptoms (dryness, itching, burning) quickly and significantly vs placebo.
- Clinical Evaluation of the Effects of Topical Indocyanine-green Mediated Photosensitiļ»æser vs Aloe Vera Gel as Adjunct Therapy to Scaling and Root Planing in Chronic Periodontitis Patients
PubMed ID: 34585874
Aloe gel adjunctively reduced periodontal inflammatory cytokines and clinical inflammation ā indicates calming of local irritation.
- Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in fixed orthodontic patients-A randomized controlled trial
PubMed ID: 35943370
Aloe vera mouthwash reduced gingival inflammation and plaque in orthodontic patients comparably to chlorhexidine ā calming local gum irritation.
- Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial
PubMed ID: 35767935
Topical aloe gel during radiotherapy lowered rates of moderateāsevere erythema and moist desquamation during peak weeks.
- Effectiveness of aloe fomentation for nipple-related complications during the early puerperium period: a randomized, controlled, interventional study
PubMed ID: 35255973
Aloe fomentation reduced some nipple complications postpartum (eschar), indicating local skin soothing/healing in superficial tissue.
- Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial
PubMed ID: 36864527
Aloeācontaining polyherbal mouthwash reduced radiotherapyārelated oral mucositis pain and severity vs placebo, consistent with irritation relief.
- The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial
PubMed ID: 37670716
Aloe gel dressings improved diabetic foot ulcer healing scores and are consistent with soothing/beneficial topical effects.
- A Randomized Single-Blinded Phase II Trial Comparing Efficacy and Quality of Life of Topical Aloe Vera Gel Plus Urea Cream Versus Urea Cream Alone for Prevention of Hand Foot Syndrome in Cancer Patients Receiving Capecitabine
PubMed ID: 38918684
Topical aloe gel + urea reduced clinically significant handāfoot syndrome vs urea alone (reduced grade 2ā3 incidence).
- Comparison of aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: a clinical trial
PubMed ID: 38229162
Aloe gel dressings substantially reduced dressingāchange pain for pressure ulcers versus saline, consistent with a soothing topical effect.
- Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study
PubMed ID: 24164309
Topical Aloe mucoadhesive gel produced high healing rates and reduced redness for minor mouth ulcers ā mucosal/skin-soothing evidence.
- Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study
PubMed ID: 8765459
Randomized double-blind topical 0.5% Aloe cream markedly improved mildāmoderate plaque psoriasis vs placebo (large effect).
- The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial
PubMed ID: 18093246
Highāconcentration Aloe gel significantly reduced UVB-induced erythema at 48 h (anti-inflammatory/soothing effect).
- Efficacy of aloe vera gel in the treatment of vulval lichen planus
PubMed ID: 18940117
Topical Aloe gel produced large improvements in vulval lichen planus symptoms and signs vs placebo (strong soothing/therapeutic effect).
- Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test
PubMed ID: 18253066
Highāconcentration Aloe gel reduced UV-induced redness relative to placebo (soothing/anti-inflammatory).
- A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis
PubMed ID: 19686327
Aloe cream produced slightly greater PASI improvement than 0.1% triamcinolone in psoriasis (topical skin benefit).
- Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study
PubMed ID: 19562446
Aloe cream healed second-degree burns faster than silver sulfadiazine, consistent with a soothing/therapeutic topical effect.
- Preliminary study of effectiveness of aloe vera in scabies treatment
PubMed ID: 19274696
Small trial found Aloe gel roughly as effective as benzyl benzoate for scabies ā symptom/lesion improvement implies topical soothing.
- Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study
PubMed ID: 20569031
Topical Aloe cream after hemorrhoid surgery reduced pain and sped healing ā clear topical soothing/antiāinflammatory effect.
- Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study
PubMed ID: 20923446
Topical Aloe for oral lichen planus increased pain remission rates and improved quality of life vs placebo.
- Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial
PubMed ID: 21988705
Aloe + olive oil cream significantly reduced chronic pruritus from mustard-gas skin injuries, comparable to steroid.
- Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial
PubMed ID: 21681079
Aloe mouthwash improved pain and lesion healing in oral lichen planus nearly as well as steroid treatment.
- Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus
PubMed ID: 23041995
Aloe gel improved oral lichen planus signs/symptoms better than triamcinolone in a randomized trial.
- A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children
PubMed ID: 22606064
Topical Aloe cream improved diaper dermatitis severity in children (though Calendula was superior).
- Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial
PubMed ID: 23336746
Aloe + tretinoin reduced erythema and irritation compared with tretinoin + vehicle in acne patients.
- Effectiveness of Aloe Vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns
PubMed ID: 23894900
Aloe gel dressings for partialāthickness burns healed faster and relieved pain sooner than silver sulfadiazine ā strong soothing/healing evidence.
Pain relief (31)
- A Randomized Single-Blinded Phase II Trial Comparing Efficacy and Quality of Life of Topical Aloe Vera Gel Plus Urea Cream Versus Urea Cream Alone for Prevention of Hand Foot Syndrome in Cancer Patients Receiving Capecitabine
PubMed ID: 38918684
Aloe + urea reduced clinically significant handāfoot syndrome incidence, decreasing chemotherapyārelated skin discomfort.
- Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study
PubMed ID: 24164309
Aloe mucoadhesive gel reduced pain and promoted rapid healing of minor mouth ulcers.
- Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study
PubMed ID: 8765459
Topical Aloe cream often cured or markedly improved plaque psoriasis and associated symptoms (discomfort relief).
- The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial
PubMed ID: 18093246
Reduced UV erythema and inflammation implies reduced skin discomfort after UV injury.
- Efficacy of aloe vera gel in the treatment of vulval lichen planus
PubMed ID: 18940117
Marked improvement in vulval lichen planus symptoms (including discomfort) with topical Aloe vs placebo.
- Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study
PubMed ID: 19562446
Faster healing and symptomatic improvement in burns treated with Aloe cream (reduced discomfort).
- Preliminary study of effectiveness of aloe vera in scabies treatment
PubMed ID: 19274696
Comparable itch/lesion clearance to benzyl benzoate for scabies ā symptomatic benefit.
- Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study
PubMed ID: 20569031
Postoperative topical Aloe reduced pain after hemorrhoidectomy vs placebo.
- Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study
PubMed ID: 20923446
Topical Aloe increased complete pain remission rates in oral lichen planus vs placebo.
- Efficacy of Aloe vera/olive oil cream versus betamethasone cream for chronic skin lesions following sulfur mustard exposure: a randomized double-blind clinical trial
PubMed ID: 21988705
Aloe/olive oil cream reduced chronic pruritus similarly to betamethasone in mustardāgas injuries.
- Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial
PubMed ID: 21681079
Aloe mouthwash improved pain/burning in oral lichen planus to an extent comparable to steroid.
- Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus
PubMed ID: 23041995
Aloe gel produced greater symptom relief than triamcinolone for oral lichen planus in this trial.
- Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration
PubMed ID: 23240939
Acemannan reduced pain associated with oral ulcers vs vehicle.
- Effectiveness of Aloe Vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns
PubMed ID: 23894900
Aloe dressings provided earlier pain relief for partial-thickness burns vs silver sulfadiazine.
- Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds
PubMed ID: 26488737
Aloeāolive oil cream reduced wound pain more than phenytoin cream in chronic wounds (clinical pain relief).
- Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study
PubMed ID: 27314762
Aloe (systemic + topical) improved burning sensation and mouth opening in oral submucous fibrosis (reduced mucosal discomfort).
- The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women
PubMed ID: 28521546
Topical Aloe cream in pregnancy reduced itching and erythema of stretch marks (relief of symptomatic discomfort).
- The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial
PubMed ID: 30268162
Reduced local pain at pressureāprone sites and lowered early pressureāulcer incidence ā moderate discomfort reduction.
- Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial
PubMed ID: 31664632
Large RCT: Aloe gel greatly reduced painful orthodontic ulcers vs chlorhexidine ā strong discomfort relief.
- Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients
PubMed ID: 32404169
Topical aloe markedly reduced pelvic RTārelated rectal symptoms and CRP ā notable symptom/comfort benefit.
- Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind
PubMed ID: 34162822
Aloe mouthwash improved xerostomia symptoms in diabetics compared with saline ā reduced oral discomfort.
- A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial
PubMed ID: 33576219
Topical aloe reduced burning sensation in oral submucous fibrosisāclear symptomatic relief.
- A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
PubMed ID: 33811776
Aloeācontaining lotion produced better itch relief than hydrocortisone, reducing symptom discomfort.
- Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study
PubMed ID: 33832645
Vaginal gel with aloe rapidly reduced symptoms (dryness, itch, burning) improving patient comfort and sexual function.
- Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial
PubMed ID: 35767935
Aloe gel reduced incidence/severity of radiationārelated burning and moist desquamation at peak weeks, decreasing patient discomfort.
- Effectiveness of aloe fomentation for nipple-related complications during the early puerperium period: a randomized, controlled, interventional study
PubMed ID: 35255973
Aloe fomentation on nipples decreased some breastfeedingārelated nipple problems (notably eschar) and likely reduced shortāterm discomfort.
- Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial
PubMed ID: 36864527
Polyherbal (including aloe) mouthwash reduced mucositis pain and severity compared with placebo.
- The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial
PubMed ID: 37670716
Aloe dressings for diabetic foot ulcers led to faster healing, which correlated with symptomatic improvement and less wound pain.
- Comparison of aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: a clinical trial
PubMed ID: 38229162
Aloe gel dressings greatly reduced pain scores for pressure ulcers versus saline over three weeks.
- Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial
PubMed ID: 39602479
Multiāingredient sprays that include aloe produced large, rapid reductions in sore throat pain and cold symptoms vs placebo ā substantial symptomatic relief (multiāingredient).
- Efficacy of an Iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: A triple-blind, placebo-controlled randomized clinical trial
PubMed ID: 39951927
Polyherbal product (includes Aloe) reduced constipation severity and improved patient satisfaction postoperatively, indicating reduction in discomfort associated with constipation.
Oral health (23)
- Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind
PubMed ID: 34162822
Tripleāblind RCT: Aloe mouthwash improved xerostomia symptoms in diabetics vs saline ā clear oral comfort benefit.
- A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial
PubMed ID: 33576219
Topical aloe gel reduced burning in oral submucous fibrosis and improved symptomatic comfort vs comparator.
- Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study
PubMed ID: 34967575
Topical black turmeric + aloe significantly reduced burning sensation vs steroid/antioxidant therapy (multiāingredient study).
- Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study
PubMed ID: 33832645
Vaginal gel with aloe improved mucosal symptoms and sexual function; while not oral, this supports mucosal comfort properties of aloe.
- Clinical Evaluation of the Effects of Topical Indocyanine-green Mediated Photosensitiļ»æser vs Aloe Vera Gel as Adjunct Therapy to Scaling and Root Planing in Chronic Periodontitis Patients
PubMed ID: 34585874
Topical aloe gel adjunct to scaling/root planing reduced periodontal inflammation and improved clinical periodontal measures ā supports oral symptom relief.
- Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash with chlorhexidine in fixed orthodontic patients-A randomized controlled trial
PubMed ID: 35943370
Aloe vera mouthwash reduced plaque and gingival inflammation comparably to chlorhexidine in orthodontic patients over 35 days.
- Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial
PubMed ID: 36864527
Polyherbal mouthwash containing aloe reduced radiotherapyārelated oral mucositis and pain more than placebo.
- The effects of a novel herbal toothpaste on salivary lactate dehydrogenase as a measure of cellular integrity
PubMed ID: 33064207
Herbal toothpaste including aloe reduced salivary LDH, plaque and gingivitis vs fluoride control ā supports oral mucosal integrity and comfort.
- Comparative efficacy of topical aloe vera and low-level laser therapy in the management of oral lichen planus: a randomized clinical trial
PubMed ID: 34853932
Topical Aloe reduced pain and lesion activity in oral lichen planus vs baseline (less than laser) ā moderate oral comfort evidence.
- The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children
PubMed ID: 31111439
Aloe mouthwash in children reduced plaque, gingivitis and S. mutans comparable to chlorhexidine ā supports oral health/comfort.
- Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial
PubMed ID: 31664632
Large RCT: topical Aloe gel dramatically lowered risk of painful orthodontic traumatic ulcers vs chlorhexidine ā very strong oral comfort evidence.
- Antiplaque, Antifungal Effectiveness of Aloevera Among Intellectually Disabled Adolescents: Pilot Study
PubMed ID: 29335048
Doubleāblind RCT in adolescents: Aloe toothpaste reduced plaque, gingival inflammation and oral Candidaāstrong oral health/comfort benefit.
- Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study
PubMed ID: 27314762
Systemic + topical Aloe improved burning sensation and mouth function in oral submucous fibrosis, supporting oral comfort.
- Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes
PubMed ID: 26264630
Acemannan used in primaryātooth pulp capping produced favorable histology and comparable clinical successāoral tissue benefit in pediatric dentistry.
- Adjunctive Local Delivery of Aloe Vera Gel in Patients With Type 2 Diabetes and Chronic Periodontitis: A Randomized, Controlled Clinical Trial
PubMed ID: 26447752
Local Aloe gel as adjunct to periodontal therapy improved plaque, bleeding and probing depth in diabetic patientsāmeaningful oral health benefit.
- Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial
PubMed ID: 24795515
Large RCT: Aloe vera mouthwash reduced 4āday plaque regrowth about as well as chlorhexidine without stainingārobust oral hygiene/comfort evidence.
- Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis
PubMed ID: 24237724
Aloe gel addāon therapy improved multiple OSMF symptoms versus nonāAloe groups in a randomized trial.
- Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration
PubMed ID: 23240939
Acemannan reduced oral ulcer size and pain better than vehicle, supporting oral mucosal benefits.
- Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus
PubMed ID: 23041995
Aloe gel improved oral lichen planus signs/symptoms better than triamcinolone in an RCT.
- Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial
PubMed ID: 21681079
Aloe mouthwash produced clinical and symptomatic improvements in oral lichen planus comparable to topical steroid.
- Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial
PubMed ID: 22087805
Aloeācontaining toothpaste reduced plaque and gingival inflammation vs placebo (though other formulation actives present).
- Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study
PubMed ID: 20923446
Topical Aloe improved pain remission rates and quality of life in oral lichen planus versus placebo.
- Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study
PubMed ID: 24164309
Aloe mucoadhesive gel produced high rates (~77%) of complete healing of minor mouth ulcers and reduced signs by day 6.
Skin repair (19)
- The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized, Double-blind Clinical Trial
PubMed ID: 37670716
Doubleāblind RCT: aloe gel dressings improved diabetic foot ulcer healing scores over 3 weeks vs control.
- A Randomized Single-Blinded Phase II Trial Comparing Efficacy and Quality of Life of Topical Aloe Vera Gel Plus Urea Cream Versus Urea Cream Alone for Prevention of Hand Foot Syndrome in Cancer Patients Receiving Capecitabine
PubMed ID: 38918684
Adding topical aloe to urea cream reduced handāfoot syndrome severityāindirect evidence of enhanced skin recovery in chemotherapyārelated injury.
- Comparison of aloe vera gel dressing with conventional dressing on pressure ulcer pain reduction: a clinical trial
PubMed ID: 38229162
Aloe gel dressings reduced dressingāchange pain and improved pressure ulcer outcomes, consistent with wound repair enhancement.
- Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study
PubMed ID: 8765459
Topical Aloe cream markedly improved psoriasis lesions ā indicates promotion of skin lesion resolution.
- Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study
PubMed ID: 24164309
High completeāhealing rate of minor mouth ulcers with Aloe mucoadhesive gel vs vehicle.
- Efficacy of aloe vera gel in the treatment of vulval lichen planus
PubMed ID: 18940117
Topical Aloe improved vulval lichen planus signs and symptoms ā supports local healing/repair.
- A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis
PubMed ID: 19686327
Aloe cream produced slightly greater PASI improvement than topical steroid ā clinical healing/lesion improvement in psoriasis.
- Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study
PubMed ID: 19562446
Randomized trial: Aloe cream produced faster re-epithelialization of second-degree burns than silver sulfadiazine (robust healing benefit).
- Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study
PubMed ID: 20569031
Topical Aloe after hemorrhoid surgery accelerated wound healing and reduced analgesic needs.
- A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children
PubMed ID: 22606064
Aloe cream improved diaper dermatitis severity, indicating topical healing effects.
- Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration
PubMed ID: 23240939
Acemannan reduced ulcer size vs vehicle, indicating woundārepair activity of Aloe polysaccharides.
- Effectiveness of Aloe Vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns
PubMed ID: 23894900
Aloe gel dressings for partialāthickness burns resulted in faster wound epithelialization than silver sulfadiazine.
- Aloe vera gel and cesarean wound healing; a randomized controlled clinical trial
PubMed ID: 25560349
Fresh Aloe gel improved cesarean wound REEDA score at 24āh vs dressing controlāclinical evidence of enhanced early wound repair.
- Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds
PubMed ID: 26488737
Randomized doubleāblind trial: Aloe veraāolive oil cream markedly improved chronic wound healing vs phenytoin (strong clinical wound repair evidence).
- Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes
PubMed ID: 26264630
Acemannan (Aloeāderived) in primary teeth gave superior histopathology vs calcium hydroxideāevidence of enhanced tissue repair.
- The effect of Aloe Vera gel on prevention of pressure ulcers in patients hospitalized in the orthopedic wards: a randomized triple-blind clinical trial
PubMed ID: 30268162
Reduced early pressureāulcer incidence and local signs indicates Aloe supports skin integrity and repair in atārisk patients.
- Efficacy of Aloe vera/ Plantago Major Gel in Diabetic Foot Ulcer: A Randomized Double-Blind Clinical Trial
PubMed ID: 29336265
Topical Aloe+Plantago gel improved diabetic foot ulcer scores and reduced surface area vs placebo ā supports ulcer healing (multiāingredient).
- Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial
PubMed ID: 31664632
Prevention of traumatic oral ulcers implies contribution to mucosal integrity/repair processes.
- Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial
PubMed ID: 35767935
Topical aloe reduced peak radiotherapy skin toxicity and moist desquamation (fewer severe episodes), indicating support for skin integrity during injury.
Skin appearance (13)
- The effect of Aloe vera gel and sweet almond oil on striae gravidarum in nulliparous women
PubMed ID: 28521546
Topical Aloe reduced itching/erythema and slowed progression of striae gravidarum, indicating improved skin appearance in pregnancy.
- Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study
PubMed ID: 8765459
Topical Aloe cream markedly improved psoriatic plaques and PASI scores vs placebo (clear improvement in skin appearance).
- Efficacy of aloe vera gel in the treatment of vulval lichen planus
PubMed ID: 18940117
Marked clinical improvement in vulval lichen planus with topical Aloe indicates better skin appearance.
- A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis
PubMed ID: 19686327
Aloe cream produced a slightly greater PASI improvement than triamcinolone (clinically measurable appearance benefit).
- Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study
PubMed ID: 19562446
Faster burn healing with Aloe suggests better cosmetic/appearance outcomes at healed sites.
- A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children
PubMed ID: 22606064
Topical Aloe reduced diaper dermatitis severity, consistent with improved local skin appearance.
- Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial
PubMed ID: 23336746
Adding Aloe gel to tretinoin significantly improved acne lesion counts and reduced erythema versus tretinoin alone.
- Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
PubMed ID: 28088806
Randomized doubleāblind placeboācontrolled trial: oral Aloe sterol improved skin elasticity, hydration and dermal collagen measures in healthy women (strong objective appearance benefits).
- Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy
PubMed ID: 28139161
Large RCT: topical liposomeāencapsulated Aloe gel produced a clinically meaningful 32% MASI improvement vs 10% control in melasma ā strong evidence for appearance improvement.
- Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial
PubMed ID: 32515040
Oral Aloeāderived sterols increased dermal collagen score and improved skin hydration/TEWL ā objective improvements in skin quality/appearance.
- Adding herbal extracts to silicone gel on post-sternotomy scar: a prospective randomised double-blind study
PubMed ID: 32279615
Silicone + herbal extracts (incl. Aloe) improved scar vascularity/pigmentation vs silicone alone ā modest appearance benefit.
- A new product of multi-plant extracts improved skin photoaging: An oral intake in vivo study
PubMed ID: 34791771
Oral multiāplant product (including aloe) improved objective skin measures (hydration, TEWL, elasticity, pigmentation) vs placebo over 12 weeks; aloe may contribute though product was multiāingredient.
- Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial
PubMed ID: 35767935
Topical aloe reduced severity of radiotherapyāinduced erythema and moist desquamation in peak weeks ā likely preserves skin appearance during treatment.
Wellbeing (11)
- Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis
PubMed ID: 22563189
Aloe highāmolecularāweight fraction reduced liver enzymes and fibrosis markers in periportal fibrosis ā supports internal hepatic balance.
- Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis
PubMed ID: 15043514
Oral Aloe improved clinical and histologic UC measures ā suggests restoration of intestinal homeostasis/internal balance.
- Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study
PubMed ID: 20923446
Topical Aloe in oral lichen planus improved quality-of-life (OHIP-49) scores compared with placebo.
- Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial
PubMed ID: 22198821
Oral Aloe gel added to standard therapy lowered fasting glucose, HbA1c, total cholesterol and LDL in type 2 diabetics ā supports metabolic balance.
- Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial
PubMed ID: 23735317
Aloe gel complex modestly reduced body weight, fat mass and improved insulin/HOMAāIR in obese people with prediabetes/early diabetes.
- Aloe Vera; A new treatment for atrophic vaginitis, A randomized double-blinded controlled trial
PubMed ID: 33383112
Topical vaginal Aloe cream improved maturation index, VHI and atrophy symptoms nearly as well as estrogen ā strong evidence for restoring local mucosal balance.
- Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients
PubMed ID: 32404169
Marked reduction in acute radiation proctitis incidence and CRP suggests maintenance/restoration of rectal mucosal homeostasis.
- Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study
PubMed ID: 33832645
Vaginal gel including aloe improved sexual function (FSFI) and vaginal health measures, which can increase wellbeing/sex life satisfaction.
- The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial
PubMed ID: 36808781
Oral standardized aloe capsule improved quality of life, NYHA class and sleep measures in systolic heart failureāmeaningful wellbeing signal (small trial).
- Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial
PubMed ID: 39602479
Multiāingredient mucosal sprays including aloe markedly reduced sore throat pain and common cold symptom severity vs placebo (large RCT); overall wellbeing improved, though effect is not aloeāspecific.
- Efficacy of an Iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: A triple-blind, placebo-controlled randomized clinical trial
PubMed ID: 39951927
Postoperative improvement in constipation and patient satisfaction with a polyherbal product including Aloe suggests a contribution to wellbeing, but multi-ingredient product limits attribution.
Digestive support (7)
- Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients
PubMed ID: 32404169
3% topical aloe during pelvic radiotherapy markedly reduced acute radiation proctitis symptoms (diarrhea/urgency) ā direct GI benefit.
- Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial
PubMed ID: 26742306
Pilot RCT: standardized Aloe syrup reduced frequency of GERD symptoms over 4 weeks (direct digestive symptom benefit).
- Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis
PubMed ID: 15043514
Oral Aloe gel produced significant clinical and histologic improvement in mildāmoderate ulcerative colitis versus placebo.
- A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation
PubMed ID: 1800188
Combination capsule with Aloe increased bowel movement frequency and softened stools versus placebo, indicating improved bowel-related digestion.
- Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study
PubMed ID: 31686768
Prebiotic powder (contains small % aloe) increased stool frequency and beneficial R. hominis ā moderate support for digestive function (confounded product).
- A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200Ā®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 26405698
Randomized placeboācontrolled trial showed improvements in IBS symptoms with oral Aloe (moderate evidence).
- Efficacy of an Iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: A triple-blind, placebo-controlled randomized clinical trial
PubMed ID: 39951927
Polyherbal capsule containing Aloe improved postoperative constipation severity and stool consistency ā supports digestive function though product was multi-ingredient.
Immune support (4)
- Effect of processed aloe vera gel on immunogenicity in inactivated quadrivalent influenza vaccine and upper respiratory tract infection in healthy adults: A randomized double-blind placebo-controlled trial
PubMed ID: 34385093
Oral processed aloe gel increased antibody response to A/H3N2 and reduced URIs ā moderate clinical immune support (straināspecific).
- Clinical Evaluation of the Effects of Topical Indocyanine-green Mediated Photosensitiļ»æser vs Aloe Vera Gel as Adjunct Therapy to Scaling and Root Planing in Chronic Periodontitis Patients
PubMed ID: 34585874
Topical aloe gel adjunct reduced periodontal inflammatory cytokines (ILā6, ILā8, TNFāĪ±), indicating local immunomodulatory effects.
- Prevention of acute radiation-induced Proctitis by Aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in Pelvic Cancer patients
PubMed ID: 32404169
Topical 3% aloe during pelvic RT reduced CRP and proctitis incidence, indicating antiāinflammatory/systemic immune effects in this setting.
- An Assessment of the Glyconutrient Ambrotoseā¢ on Immunity, Gut Health, and Safety in Men and Women: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial
PubMed ID: 32545396
Ambrotose (contains aloe gel) produced modest immune changes (āmonocytes, āILā10) in healthy adults ā evidence of immunomodulation.
Hydration (4)
- Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
PubMed ID: 28088806
Oral Aloe sterol supplementation improved skin hydration (objective measures) over 12 weeks in healthy women.
- Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial
PubMed ID: 32515040
Oral Aloe sterols reduced TEWL and increased dermal collagen and hydration in subjects with dry skin ā strong evidence for skin hydration benefits.
- Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind
PubMed ID: 34162822
Aloe mouthwash significantly reduced xerostomia symptoms in diabetic patients vs saline ā supports oral hydration/comfort.
- A new product of multi-plant extracts improved skin photoaging: An oral intake in vivo study
PubMed ID: 34791771
Oral multiāplant product containing aloe improved objective skin hydration and TEWL versus placebo; specific aloe contribution uncertain but supports hydration effects.
Bowel regularity (3)
- Efficacy of an Iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: A triple-blind, placebo-controlled randomized clinical trial
PubMed ID: 39951927
Polyherbal capsule including Aloe significantly decreased constipation severity and improved stool consistency after surgery ā strong clinical support for promoting regularity (though multi-herb).
- A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation
PubMed ID: 1800188
Combination capsule containing Aloe increased bowel movement frequency and softened stools vs placebo, directly supporting regularity.
- Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study
PubMed ID: 31686768
Prebiotic product (contains ~3.9% aloe) increased stool frequency in mild constipation ā moderate effect though multiācomponent.
Detoxification (2)
- Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers
PubMed ID: 31112706
Randomized study in smokers: isolated Aloe polysaccharide markedly increased urinary excretion of tobacco toxins (BaP, cotinine) ā strong direct detoxification evidence (APS form).
- Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis
PubMed ID: 22563189
Aloe AHM reduced liver enzymes and fibrosis markers and improved histology in periportal fibrosis ā supports hepatic detoxification/fibrosis improvement.
Bloating & gas (1)
- A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200Ā®) in Patients with Irritable Bowel Syndrome: a Randomized, Double-Blind, Placebo-Controlled Study
PubMed ID: 26405698
Oral Aloe improved IBS symptom scores (includes bloating) vs placebo trends; signal but primary endpoint not met.
Similar by evidence
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Products with Aloe Vera
Search all1315 products whose verified label declares Aloe Vera ā not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet ā this is what the field is asking, not what it found.