Licorice
15 benefits mapped to clinical evidence across supplements.
Dose per serving from products
938 products in our catalogue print how much Licorice a serving holds.
Most common: 25 mg to 50 mg, 30% of 938 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 46 |
| 10 mg to 25 mg | 190 |
| 25 mg to 50 mg | 283 |
| 50 mg to 100 mg | 174 |
| 100 mg to 250 mg | 118 |
| 250 mg to 500 mg | 63 |
| 500 mg to 1 g | 44 |
| over 1 g | 20 |
Dose per serving from research
32 study groups in 26 studies say how much Licorice participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g and 5 g to 10 g, 19% of 32 study groups each.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 2 |
| 100 mg to 250 mg | 3 |
| 250 mg to 500 mg | 5 |
| 500 mg to 1 g | 6 |
| 1 g to 2.5 g | 4 |
| 2.5 g to 5 g | 1 |
| 5 g to 10 g | 6 |
| 10 g to 25 g | 0 |
| 25 g to 50 g | 4 |
Benefit Evidence
Research sources
Oral health (13)
- The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial
PubMed ID: 32444056
Double‑blind RCT: licorice added to diphenhydramine mouth rinse significantly reduced pain and shortened healing time for recurrent aphthous stomatitis.
- Caries Preventive and Antibacterial Effects of Two Natural Mouthwashes vs Chlorhexidine in High Caries-risk Patients: A Randomized Clinical Trial
PubMed ID: 33893252
Licorice mouthwash showed antibacterial activity and favorable caries outcomes vs chlorhexidine without side effects—supports oral comfort/health.
- Comparative Study of the Effect of Licorice Muco-adhesive Film on Radiotherapy Induced Oral Mucositis, A Randomized Controlled Clinical Trial
PubMed ID: 35152194
Mucoadhesive licorice film reduced pain and mucositis severity in radiotherapy patients—clinical oral mucosal soothing effect.
- A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries
PubMed ID: 35010502
G. uralensis mouthwash eliminated S. mutans and reduced acid production at 5 days—antimicrobial action supports less irritation and better oral environment.
- Efficacy of Licorice on Salivary Streptococcus mutans Levels vs Chlorhexidine Mouthwash in High Caries Risk Patients: A Randomized Clinical Trial
PubMed ID: 34753844
Licorice mouthwash increased salivary flow and pH and matched chlorhexidine for S. mutans in high‑risk patients—helps oral environment and irritation.
- Liquorice root extracts as potent cariostatic agents in pediatric practice
PubMed ID: 24021323
Licorice mouthwashes reduced cavity‑related bacteria and raised salivary pH immediately and were palatable — supports oral comfort and hygiene.
- A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers
PubMed ID: 18348383
Intraoral licorice patch reduced mouth ulcer size and pain faster than placebo — strong direct evidence for soothing mouth irritation.
- Effective licorice gargle juice for aphthous ulcer pain relief: A randomized double-blind placebo-controlled trial
PubMed ID: 36451559
Licorice gargle produced large, rapid reductions in aphthous ulcer pain vs placebo within 1–2 days—strong evidence for oral soothing.
- Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit
PubMed ID: 38867216
In intubated ICU patients licorice mouthwash improved oral assessment scores, indicating reduced oral irritation and better hygiene.
- Effectiveness of Glycyrrhiza uralensis extract on periodontal pathogens: a randomized controlled clinical trial
PubMed ID: 40413479
Five-day nightly licorice mouthwash markedly lowered plaque and gum inflammation versus saline, directly supporting relief of oral/mouth irritation.
- Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced oral mucositis: A randomized double-blinded clinical trial
PubMed ID: 25347930
Licorice mucoadhesive films relieved radiotherapy‑induced oral mucositis pain as effectively as topical steroid — robust clinical support.
- Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study
PubMed ID: 27565424
Licorice mouthwash gave subjective relief of dry mouth and increased salivary flow vs control in dialysis patients—direct soothing of oral discomfort.
- Impact of educational (sign language/video modeling) and therapeutic (Glycyrrhiza glabra--liquorice mouth wash) interventions on oral health pertaining to children with hearing impairment: A randomized clinical trial
PubMed ID: 31287184
Licorice mouthwash improved plaque and gingival scores in children, consistent with reduced oral irritation/inflammation.
Inflammation (11)
- The treatment of atopic dermatitis with licorice gel
PubMed ID: 14522625
Double‑blind clinical trial: topical licorice gel reduced erythema, oedema and itching in atopic dermatitis — clear anti‑inflammatory skin effect.
- Efficacy and safety of Fengshi Gutong Capsule in patients with active ankylosing spondylitis: A 4-week randomized controlled, double-blinded, double-dummy trial
PubMed ID: 34634368
Multi‑herb formula (contains licorice) reduced ASDAS‑CRP and improved ASAS20 vs NSAID in ankylosing spondylitis, consistent with anti‑inflammatory effect though multi‑ingredient.
- [Toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis with Tripterygium wilfordii]
PubMed ID: 17205826
Adding licorice to Tripterygium in RA produced improved joint outcomes and fewer adverse reactions — suggests anti‑inflammatory/adjuvant effects though in combination therapy.
- Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
PubMed ID: 30690691
Topical cream containing licorice reduced UV‑erythema comparable to 1% hydrocortisone and improved atopic dermatitis lesion scores (controlled UV model + small clinical series).
- [Adjunctive treatment of axial undifferentiated spondyloarthritis by Qiangji Recipe: a clinical study]
PubMed ID: 25790672
Adjunct multiherb containing licorice improved clinical metrics in undifferentiated spondyloarthritis (open randomized) — consistent with anti‑inflammatory action (confounded).
- Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo-controlled study
PubMed ID: 35763437
Facial serum with licorice extract reduced inflammatory acne lesions in a randomized study (adjunctive, multi‑ingredient product).
- Impact of licorice root on the burn healing process: A double-blinded randomized controlled clinical trial
PubMed ID: 36870516
Topical licorice hydrogel reduced inflammation and redness and accelerated healing in second‑degree burns (double‑blind RCT).
- Randomized investigator-blinded comparative study of moisturizer containing 4-t-butylcyclohexanol and licochalcone A versus 0.02% triamcinolone acetonide cream in facial dermatitis
PubMed ID: 29411520
Licochalcone‑containing moisturizer improved inflammatory signs in facial dermatitis comparably to low‑dose steroid in a randomized trial.
- Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial
PubMed ID: 38283346
Nebulized glycyrrhizin produced large, specific reductions in inflammatory cytokines (IL‑17A, IL‑6, IL‑8, TNF‑α) in COVID patients—strong anti‑inflammatory signal.
- Effectiveness of Glycyrrhiza uralensis extract on periodontal pathogens: a randomized controlled clinical trial
PubMed ID: 40413479
Significant reductions in gingival and plaque indices (~40–51%) indicate a clear anti-inflammatory effect in oral tissues.
- Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp
PubMed ID: 23549137
Scalp tonic containing Glycyrrhiza improved itching and reduced pro‑inflammatory markers (half‑head randomized study, small sample, multi‑active product).
Digestive support (7)
- To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori
PubMed ID: 27614124
Randomized trial: adding licorice to triple therapy meaningfully increased H. pylori eradication (overall and in peptic ulcer subset), directly relevant to GI health/digestion.
- Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial
PubMed ID: 14755152
Randomized trial of a multi‑herb preparation (contains licorice) produced clear improvement in functional dyspepsia outcomes vs placebo.
- Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy
PubMed ID: 16521190
Topical spraying of a licorice‑containing formula on spastic colon mucosa greatly reduced spasm and increased lumen area — direct antispasmodic/digestive benefit.
- [Application of dannang recipe no. 2 in the perioperative stage of laparoscopic cholecystectomy]
PubMed ID: 19317164
Perioperative multiherb decoction containing licorice significantly hastened return of bowel function after laparoscopic surgery (multiingredient confounding).
- [A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo controlled comparative study]
PubMed ID: 11505331
STW‑5 (multi‑extract including licorice) improved GIS and dyspeptic symptoms vs placebo in functional dyspepsia RCT; effect not solely attributable to licorice.
- [Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao wei yan powder]
PubMed ID: 1302542
Large older study reported substantial improvement in gastric intestinal metaplasia/atypical hyperplasia with a multi‑herb powder including licorice; supports gastric/digestive benefit though multi‑component.
- Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 39929150
Standardized deglycyrrhizinated licorice extract (GutGard) significantly reduced heartburn/reflux symptom scores vs placebo in 200 adults—strong evidence for digestive symptom relief from a licorice‑standardized product.
Skin soothing (7)
- Efficacy and safety of a facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glaba root extract in the treatment of maskne: A randomized placebo-controlled study
PubMed ID: 35763437
Facial serum containing licorice extract reduced inflammatory acne lesions significantly vs placebo in a randomized trial (adjunct product).
- Impact of licorice root on the burn healing process: A double-blinded randomized controlled clinical trial
PubMed ID: 36870516
Licorice hydrogel reduced wound inflammation/redness and accelerated healing in second‑degree burn patients (RCT).
- Randomized investigator-blinded comparative study of moisturizer containing 4-t-butylcyclohexanol and licochalcone A versus 0.02% triamcinolone acetonide cream in facial dermatitis
PubMed ID: 29411520
Licochalcone A moisturizer improved facial dermatitis signs and skin hydration vs low‑dose steroid in a randomized comparative study.
- Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp
PubMed ID: 23549137
Topical scalp tonic containing Glycyrrhiza inflata improved scalp moisture and reduced itching/inflammation on treated side (small half‑head study).
- The treatment of atopic dermatitis with licorice gel
PubMed ID: 14522625
Topical licorice gel (2%) reduced erythema, oedema and itching in atopic dermatitis in a double‑blind trial — clear soothing effect.
- Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract
PubMed ID: 30690691
Topical formulation containing licorice reduced UV‑erythema and improved atopic dermatitis SCORAD quickly; strong topical anti‑inflammatory/soothing evidence in humans.
- Adjuvant role of a new emollient cream in patients with palmar and/or plantar psoriasis: a pilot randomized open-label study
PubMed ID: 21139557
Licorice extract in an emollient improved signs/symptoms in palmar/plantar psoriasis when added to steroid — supportive adjuvant skin benefit.
Stomach comfort (5)
- Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial
PubMed ID: 39929150
Standardized deglycyrrhizinated licorice extract (GutGard) produced clinically meaningful reductions in heartburn and reflux symptoms vs placebo in a well‑powered RCT.
- To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori
PubMed ID: 27614124
Enhancing H. pylori eradication and better peptic ulcer response directly reduces stomach pathology and discomfort.
- Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy
PubMed ID: 16521190
Marked antispasmodic effect on colonic spasm (visualized increase in lumen area) maps well onto easing abdominal/stomach discomfort caused by spasm.
- Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial
PubMed ID: 14755152
Multi‑herb product (includes licorice) improved dyspepsia measures and complete relief rates vs placebo.
- [A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo controlled comparative study]
PubMed ID: 11505331
STW‑5 multi‑extract reduced dyspeptic symptom scores vs placebo in functional dyspepsia trial; likely eased stomach discomfort though licorice was one of several extracts.
Respiratory comfort (5)
- A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing
PubMed ID: 23921656
Preinduction gargle reduced postoperative sore throat and related discomfort (improved perioperative respiratory comfort).
- An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study
PubMed ID: 19535697
Licorice gargle lowered postoperative sore throat and cough severity — clinically meaningful respiratory symptom relief.
- Effect of preoperative licorice lozenges on incidence of postextubation cough and sore throat in smokers undergoing general anesthesia and endotracheal intubation
PubMed ID: 24180166
Lozenges reduced cough and improved sore‑throat outcomes in smokers around anesthesia — supports short‑term respiratory comfort.
- The effectiveness of a traditional Persian medicine preparation in the treatment of chronic cough: A randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 32147070
Licorice pastilles improved chronic cough severity and QoL, indicating improved respiratory comfort in chronic cough patients.
- Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial
PubMed ID: 38283346
Nebulized glycyrrhizin produced marked reductions in proinflammatory cytokines in mild–moderate COVID, plausibly improving respiratory comfort though clinical outcomes limited.
Cough & throat (4)
- The effectiveness of a traditional Persian medicine preparation in the treatment of chronic cough: A randomized, double-blinded, placebo-controlled clinical trial
PubMed ID: 32147070
Randomized double‑blind trial: licorice pastilles modestly reduced chronic cough severity and improved cough-related QoL versus placebo.
- A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing
PubMed ID: 23921656
Large randomized double‑blind trial: preinduction licorice gargle substantially and significantly reduced postoperative sore throat incidence.
- An evaluation of the efficacy of licorice gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study
PubMed ID: 19535697
Randomized trial showed licorice gargle reduced incidence/severity of postoperative sore throat and immediate postextubation cough.
- Effect of preoperative licorice lozenges on incidence of postextubation cough and sore throat in smokers undergoing general anesthesia and endotracheal intubation
PubMed ID: 24180166
Randomized trial in smokers: licorice lozenges before anesthesia reduced postextubation cough and increased proportion with no sore throat at 12–24 h.
Menstrual comfort (4)
- Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial
PubMed ID: 28685911
Combined herbal formula including licorice plus lifestyle reduced menstrual cycle length (oligomenorrhoea) and improved weight/insulin in PCOS—meaningful cycle symptom improvement though multi‑herb.
- Shaoyao-Gancao decoction for the treatment of muscle cramps in maintenance hemodialysis: A prospective randomized crossover controlled trial
PubMed ID: 40204247
Shaoyao‑Gancao (which contains Glycyrrhiza) significantly reduced muscle cramp frequency and pain in hemodialysis patients; Shaoyao‑Gancao is traditionally used for cramp relief (relevance to menstrual cramps plausible though this trial studied dialysis cramps and is multiherb).
- Analysis of Unani coded formulation on the hormonal parameters of patients with polycystic ovarian syndrome
PubMed ID: 34602412
Unani polyherbal product (contains licorice) improved menstrual flow and hormonal markers in PCOS patients, indicating benefit for cycle symptoms (multi‑herb).
- Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial
PubMed ID: 39080737
Licorice extract added to low‑calorie diet in PCOS produced notable weight/insulin improvements and likely improved menstrual regularity (study focused on metabolic/hormonal improvements).
Metabolism (4)
- Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial
PubMed ID: 39080737
Licorice + low-calorie diet produced substantial weight, glucose and lipid improvements in PCOS women; strong metabolic signal (diet combo).
- Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial
PubMed ID: 35785498
Randomized trial in NAFLD showed licorice root powder improved insulin, HOMA‑IR and hepatic steatosis — direct metabolic benefit.
- The effects of licorice flavonoid oil with respect to increasing muscle mass: a randomized, double-blind, placebo-controlled trial
PubMed ID: 27643690
Randomized trial showed reduced body fat and increased trunk muscle mass, directly supporting metabolic/body-composition balance.
- The effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trial
PubMed ID: 32162239
LFO plus exercise reduced BMI/body fat and improved balance; supports metabolic improvements though combined with exercise.
Hormone balance (3)
- Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial
PubMed ID: 28685911
Herbal formula including licorice improved menstrual irregularity and fasting insulin in overweight women with PCOS; licorice may have contributed to cycle/hormone effects though multi‑ingredient.
- Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial
PubMed ID: 39080737
Licorice extract plus low‑calorie diet in PCOS markedly improved weight, glucose and insulin resistance (HOMA‑IR) and may influence androgen/menstrual physiology—strong metabolic/hormonal signal.
- Analysis of Unani coded formulation on the hormonal parameters of patients with polycystic ovarian syndrome
PubMed ID: 34602412
Unani polyherbal product containing licorice reduced prolactin and insulin and improved menstrual flow in PCOS; multi‑herb but clinically relevant hormonal changes.
Detoxification (3)
- Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double-blind clinical trial
PubMed ID: 35785498
12‑week licorice root powder improved liver enzymes and hepatic steatosis in NAFLD — strong evidence for liver/detox support.
- [Effect of rhubarb as the main composition of sequential treatment in patients with acute paraquat poisoning: a prospective clinical research]
PubMed ID: 25891453
Multiherb TCM (including licorice) accelerated paraquat clearance and improved outcomes in poisoning — relevant to detoxification though multiherb confounded.
- The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial
PubMed ID: 22308054
Double‑blind RCT showed aqueous licorice root extract reduced ALT and AST — supports liver/detox function.
Bloating & gas (2)
- Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy
PubMed ID: 16521190
Direct, image‑based antispasmodic effect of a licorice‑containing formula on colonic lumen (large increase in intraluminal area) — strong mechanistic link to reduced bloating.
- [Application of dannang recipe no. 2 in the perioperative stage of laparoscopic cholecystectomy]
PubMed ID: 19317164
Multiherb perioperative decoction containing small licorice sped return of bowel sounds and gas, consistent with reduced postoperative bloating (multiingredient confounding).
Immune support (2)
- A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries
PubMed ID: 35010502
G. uralensis mouthwash markedly reduced S. mutans and acid production—antibacterial action supporting oral host defenses.
- Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial
PubMed ID: 38283346
Nebulized glycyrrhizin produced large cytokine modulations (IL‑17A, IL‑6 etc.) and altered antibody responses—clear immune-modulatory effects.
Vitality (1)
- Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial
PubMed ID: 39080737
Marked metabolic improvements in PCOS (weight, glucose, lipids) plausibly support improved vitality/energy.
Mucus clearance (1)
- Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial
PubMed ID: 38283346
Nebulized glycyrrhizin reduced airway inflammatory cytokines in COVID which can lessen mucus production/viscosity; plausible mucus‑clearing effect though not directly measured.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Licorice
Search all3146 products whose verified label declares Licorice — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.