Lemon Balm
11 benefits mapped to clinical evidence across supplements.
Dose per serving from products
226 products in our catalogue print how much Lemon Balm a serving holds.
Most common: 50 mg to 100 mg, 27% of 226 products.
| Dose per serving | Products |
|---|---|
| 1 mg or less | 12 |
| 1 mg to 2.5 mg | 0 |
| 2.5 mg to 5 mg | 1 |
| 5 mg to 10 mg | 9 |
| 10 mg to 25 mg | 20 |
| 25 mg to 50 mg | 32 |
| 50 mg to 100 mg | 61 |
| 100 mg to 250 mg | 48 |
| 250 mg to 500 mg | 20 |
| 500 mg to 1 g | 9 |
| 1 g to 2.5 g | 14 |
Dose per serving from research
27 study groups in 16 studies say how much Lemon Balm participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 52% of 27 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg or less | 1 |
| 250 mg to 500 mg | 5 |
| 500 mg to 1 g | 14 |
| 1 g to 2.5 g | 3 |
| 2.5 g to 5 g | 4 |
Benefit Evidence
Sleep onset/sleep −2.9 ISI
Sleep disturbance −38%
Sleep onset improved p<0.05
Research sources
Mood balance (15)
- Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial
PubMed ID: 28665038
Multi‑ingredient product including Melissa officinalis reduced infant crying (signal of calmer behavior), though effect can't be attributed solely to lemon balm.
- The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial
PubMed ID: 33465795
Direct RCT in menopausal women: Melissa officinalis improved MENQOL psychosocial domain and sleep‑related symptoms versus citalopram/placebo.
- A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia
PubMed ID: 30670268
Lemon balm essential oil reduced agitation and irritability in non‑demented nursing‑home residents (subgroup effect).
- A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression
PubMed ID: 32620104
Melissa officinalis capsules produced ~‑8.5 HAM‑D reduction comparable to fluoxetine (small trial, no placebo).
- Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
PubMed ID: 12143909
Strong RCT evidence: lemon‑balm aromatherapy markedly reduced agitation and improved constructive/social activity in severe dementia.
- Anti-stress effects of lemon balm-containing foods
PubMed ID: 25360512
Significant reductions in state anxiety (STAI-S) in controlled crossover studies indicate a calming effect.
- Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety
PubMed ID: 25680840
Randomized trial reported decreased anxiety and fewer anxious cases, directly supporting a calmer mood effect.
- The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina
PubMed ID: 29908682
RCT reported decreased anxiety/stress and depression—consistent with a calmer mood effect.
- Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department
PubMed ID: 34247027
Inhaled lemon balm essential oil transiently lowered stress scores and heart rate, consistent with short‑term calming.
- The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial
PubMed ID: 37131158
T2D RCT demonstrated clinically meaningful reductions in anxiety and depression consistent with a calmer mood.
- Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial
PubMed ID: 38937193
Herbal formula significantly improved depression scores (large effect sizes) in IBS‑C patients — direct evidence for mood uplift.
- The effectiveness of Melissa officinalis L. essential oil inhalation on anxiety and symptom burden of hemodialysis patients: a randomized trial study
PubMed ID: 40082838
RCT of lemon balm essential oil inhalation showed significant reductions in state anxiety — supports calmer mood.
- Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial
PubMed ID: 19274698
4‑herb formulation including Melissa lowered anxiety and depression ratings over 2 weeks, consistent with calmer mood.
- Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study
PubMed ID: 29433687
Subjective anxiety was attenuated in men after a 4‑herb extract containing lemon balm (acute stress model).
- A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants
PubMed ID: 16041731
Phytotherapeutic agent (Melissa + chamomile + fennel) markedly reduced crying time in colicky infants, reflecting reduced irritability/restlessness (multi‑herb).
Stress & Anxiety (14)
- Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial
PubMed ID: 19274698
4‑herb combination including lemon balm produced greater reductions in anxiety (VAS) than comparator/placebo in an RCT.
- Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study
PubMed ID: 29433687
Acute stress trial: 4‑herb extract (includes Melissa) significantly reduced self‑reported anxiety vs placebo/no‑treatment.
- A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants
PubMed ID: 16041731
Large reduction in infant crying (colic) with a multi‑herb product containing Melissa indicates eased restlessness in infants.
- A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia
PubMed ID: 30670268
Essential oil decreased certain agitation behaviors in non‑demented nursing‑home residents, consistent with eased restlessness.
- Homeopathic medicine of Melissa officinalis combined or not with Phytolacca decandra in the treatment of possible sleep bruxism in children: A crossover randomized triple-blinded controlled clinical trial
PubMed ID: 30831467
Bruxism VAS decreased with homeopathic Melissa officinalis; bruxism is often linked to tension—small study, subjective outcomes.
- The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina
PubMed ID: 29908682
Placebo‑controlled RCT found a statistically significant reduction in anxiety scores with 3 g/day Melissa officinalis over 8 weeks.
- Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety
PubMed ID: 25680840
Double‑blind RCT showed decreased anxiety (GHQ‑28) and fewer anxious participants versus placebo—direct clinical evidence.
- Anti-stress effects of lemon balm-containing foods
PubMed ID: 25360512
Direct, randomized, placebo-controlled crossover evidence: lowered STAI-S and attenuated cortisol responses to stress.
- Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
PubMed ID: 12143909
High‑quality RCT: Melissa aromatherapy produced marked calming/reduction in agitation in severe dementia.
- The effectiveness of Melissa officinalis L. essential oil inhalation on anxiety and symptom burden of hemodialysis patients: a randomized trial study
PubMed ID: 40082838
Direct RCT evidence: inhalation sessions decreased state anxiety (statistically significant) in hemodialysis patients.
- Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial
PubMed ID: 38937193
Herbal formula including lemon balm produced large improvements in anxiety scores vs placebo.
- The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial
PubMed ID: 37131158
Randomized double‑blind placebo‑controlled trial found significant reductions in anxiety (BAI) with lemon balm extract.
- Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department
PubMed ID: 34247027
Aromatherapy with lemon balm EO produced immediate, measurable reductions in stress scores and heart rate consistent with a calming effect.
- Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial
PubMed ID: 34766389
Large short‑term BP reductions in a randomized crossover trial align with decreased physiological arousal (calming).
Wellbeing (12)
- Safety and efficacy of Melissa officinalis (lemon balm) on ApoA-I, Apo B, lipid ratio and ICAM-1 in type 2 diabetes patients: A randomized, double-blinded clinical trial
PubMed ID: 30219475
12‑week extract trial improved Apo A‑I and lipid ratios—supports metabolic health though effects are modest.
- The effects of Melissa officinalis (lemon balm) in chronic stable angina on serum biomarkers of oxidative stress, inflammation and lipid profile
PubMed ID: 30045422
8‑week RCT in stable angina improved lipids and hs‑CRP, suggesting cardiovascular/metabolic wellness support.
- Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial
PubMed ID: 34766389
Randomized crossover trial found substantial short‑term reductions in BP—clinically relevant physiological benefit supporting overall wellness.
- Melissa officinalis tea favourably affects the frequency of premature ventricular beats and cardiometabolic profile among patients with premature ventricular contraction: A randomised open-label controlled trial
PubMed ID: 34309987
MO tea plus lifestyle advice improved PVC frequency and some metabolic markers over 12 weeks, supporting general cardiometabolic wellness.
- The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial
PubMed ID: 37131158
Improved mood/anxiety in a clinical population contributes to overall wellness.
- Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial
PubMed ID: 38937193
Clinical RCT showed improvements in anxiety, depression, and IBS symptoms — broad health benefits relevant to wellness.
- The effectiveness of Melissa officinalis L. essential oil inhalation on anxiety and symptom burden of hemodialysis patients: a randomized trial study
PubMed ID: 40082838
RCT of essential oil inhalation reduced anxiety and symptom burden in a clinical population, supporting global well‑being effects.
- Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial
PubMed ID: 41101745
Randomized trial of Melissa officinalis showed modest SBP/DBP reductions over 4 weeks—supports a cardiovascular/wellness benefit (limited by short duration and sample size).
- The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial
PubMed ID: 33465795
Menopausal QoL improvements with Melissa indicate broader wellness benefits in that population (direct RCT).
- Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety
PubMed ID: 25680840
Improved symptomatic burden (palpitations, anxiety) in the RCT supports short‑term wellness benefits.
- Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial
PubMed ID: 27261994
Randomized trial showed a significant LDL decrease and AST change vs placebo—evidence of a favorable metabolic/wellness signal.
- Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial
PubMed ID: 30548118
Randomized 12‑week trial in type 2 diabetes showed improvements in FBS, HbA1c and hs‑CRP—meaningful systemic health benefits supportive of overall wellness.
Relaxation (9)
- Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department
PubMed ID: 34247027
Aromatherapy with lemon balm EO produced short‑term decreases in stress and HR consistent with enhanced relaxation.
- Effect of Melissa officinalis on systolic and diastolic blood pressures in essential hypertension: A double-blind crossover clinical trial
PubMed ID: 34766389
Marked BP reductions in a crossover trial are consonant with a relaxed physiological state.
- The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina
PubMed ID: 29908682
Significant reductions in anxiety and stress are consistent with enhanced relaxation effects in the treated group.
- Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety
PubMed ID: 25680840
Clinical trial found decreased anxiety and palpitations, consistent with enhanced relaxation.
- The effectiveness of Melissa officinalis L. essential oil inhalation on anxiety and symptom burden of hemodialysis patients: a randomized trial study
PubMed ID: 40082838
Inhalation sessions produced measurable reductions in state anxiety and perceived symptoms — consistent with relaxation.
- Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
PubMed ID: 12143909
Large RCT showed substantial reductions in agitation and increased constructive activity—strong evidence of relaxation effects in dementia.
- A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia
PubMed ID: 30670268
Lemon balm essential oil reduced agitation and certain behaviors in nursing‑home residents (subgroup), implying relaxation.
- Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study
PubMed ID: 29433687
Subjective anxiety reduction under acute stress with a multi‑herb product containing Melissa is consistent with enhanced relaxation.
- Anti-stress effects of lemon balm-containing foods
PubMed ID: 25360512
Acute reductions in state anxiety and cortisol indicate an enhanced relaxation effect in healthy volunteers.
Digestive support (6)
- Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial
PubMed ID: 38937193
Herbal formula containing lemon balm significantly improved IBS‑SSS (IBS symptom severity) in IBS‑C patients — direct digestive benefit.
- The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study
PubMed ID: 16868824
Herbal product including Melissa reduced abdominal pain and bloating in IBS patients versus placebo (combination product).
- [A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo controlled comparative study]
PubMed ID: 11505331
Iberogast (contains Melissa) significantly improved functional dyspepsia symptoms vs placebo in an RCT (multi‑component product).
- Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial
PubMed ID: 14755152
Multicenter RCT of a multi‑herb preparation including lemon balm produced a large symptomatic benefit in functional dyspepsia (cannot attribute solely to Melissa).
- Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial
PubMed ID: 28665038
Multi‑ingredient herbal/probiotic product containing Melissa officinalis substantially reduced infant crying in colic—strong signal for digestive comfort though effect attribution to lemon balm alone is uncertain.
- A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants
PubMed ID: 16041731
Phytotherapeutic agent including Melissa reduced colic crying (likely via digestive symptom relief) in infants.
Stomach comfort (6)
- A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants
PubMed ID: 16041731
Colic trial (Melissa in formula) produced large decreases in infant crying likely by relieving GI discomfort.
- [A plant extract and its modified preparation in functional dyspepsia. Results of a double-blind placebo controlled comparative study]
PubMed ID: 11505331
Iberogast (multi‑herb including Melissa) improved dyspepsia symptoms — directly relevant to soothing stomach upset.
- The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study
PubMed ID: 16868824
Carmint (contains Melissa) reduced abdominal pain and bloating in IBS patients, consistent with soothing stomach upset.
- Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial
PubMed ID: 14755152
Multi‑herb preparation including Melissa produced large symptomatic benefit in functional dyspepsia—supports digestive soothing but cannot be solely attributed to lemon balm.
- Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial
PubMed ID: 28665038
Reduction in colic crying with a product including M. officinalis suggests soothing of infant GI distress, but multiple ingredients confound attribution.
- Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial
PubMed ID: 38937193
Significant reduction in IBS symptom severity suggests soothing effect on abdominal discomfort/upset in IBS‑C.
Sleep quality (4)
- The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial
PubMed ID: 33465795
Menopause RCT: Melissa improved sleep‑related symptoms and MENQOL domains versus citalopram/placebo.
- Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study
PubMed ID: 39683592
Double‑blind crossover trial of Melissa phytosome: ISI decreased ~2.9 points, deep sleep increased and REM decreased — direct evidence for sleep quality improvement.
- Valerian/lemon balm use for sleep disorders during menopause
PubMed ID: 24199972
Randomized trial of a valerian + lemon balm product in menopausal women showed improved PSQI vs placebo; effect cannot be attributed to lemon balm alone.
- The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina
PubMed ID: 29908682
Trial reported decreases in total sleep disturbance following Melissa officinalis supplementation.
Mental clarity (3)
- Anti-stress effects of lemon balm-containing foods
PubMed ID: 25360512
Improvements in working memory, tracking and specific cognitive tasks in crossover studies support clearer mental performance acutely.
- Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial
PubMed ID: 36502333
Direct, large RCT measuring cognition (ADAS‑cog, CDR‑SOB) — highly relevant to mental clarity despite null effect.
- The effect of tablet containing Boswellia serrata and Melisa officinalis extract on older adults' memory: A randomized controlled trial
PubMed ID: 29306113
Boswellia+lemon balm improved multiple memory measures in older adults (combo study) suggestive of better mental clarity.
Focus & concentration (3)
- A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age
PubMed ID: 29433682
Two‑week multi‑herb trial (including Melissa) improved delayed word recall in <63y subgroup, indicating enhanced mnemonic/attention processes.
- Anti-stress effects of lemon balm-containing foods
PubMed ID: 25360512
Controlled crossover trials showed lemon balm improved math processing, tracking and working memory in healthy adults.
- Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial
PubMed ID: 36502333
Large RCT directly assessed cognition (ADAS‑cog, CDR‑SOB) — highly relevant outcome domain even though results were null.
Sleep onset (3)
- Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study
PubMed ID: 39683592
Melissa phytosome nightly improved insomnia severity and increased deep sleep in a double‑blind crossover trial — supports a more restful bedtime routine.
- The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial
PubMed ID: 33465795
Menopause trial: Melissa improved sleep‑related symptoms, which would aid a restful bedtime routine.
- The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina
PubMed ID: 29908682
Improvements in sleep disturbance and reductions in stress/anxiety suggest benefit to bedtime routine and sleep onset/quality.
Antioxidant (2)
- The effect of supplementation of clove and agrimony or clove and lemon balm on growth performance, antioxidant status and selected indices of lipid profile of broiler chickens
PubMed ID: 21831230
Broiler study showed increased antioxidant markers (‑SH, vitamin E) and decreased MDA with lemon balm included (animal data).
- Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial
PubMed ID: 36502333
Intervention used rosmarinic acid (a known antioxidant); study did not measure antioxidant outcomes but compound relevance is high.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Lemon Balm
Search all675 products whose verified label declares Lemon Balm — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.