Butterbur
6 benefits mapped to clinical evidence across supplements.
Dose per serving from research
8 study groups in 7 studies say how much Butterbur participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg and 50 mg to 100 mg, 38% of 8 study groups each.
| Daily dose | Study groups |
|---|---|
| 25 mg or less | 1 |
| 25 mg to 50 mg | 3 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 1 |
Benefit Evidence
Nasal breathing +12%
Asthma responsiveness +0.7
Rhinitis symptoms ā
Research sources
Pain relief (4)
- An extract of Petasites hybridus is effective in the prophylaxis of migraine
PubMed ID: 11410074
Duplicate report of the same CO2 extract randomized trial showing major reduction in attack frequency.
- An extract of Petasites hybridus is effective in the prophylaxis of migraine
PubMed ID: 11020030
Randomized doubleāblind trial (60 participants) reporting up to 60% reduction in attack frequency.
- The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria
PubMed ID: 14752215
Independent reanalysis confirmed substantial and significant reduction in attacks and higher responder rates.
- Petasites hybridus root (butterbur) is an effective preventive treatment for migraine
PubMed ID: 15623680
Large RCT showed ~48% reduction in attack frequency with 75 mg BID; strongest direct evidence.
Allergy relief (3)
- Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339
PubMed ID: 16114089
Large multicenter RCT (Ze 339) improved rhinitis symptom scores comparable to fexofenadine and better than placebo.
- Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis
PubMed ID: 11799030
Large RCT showed butterbur performed about as well as cetirizine on hay fever symptom scores.
- Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 15611396
Wellāpowered doseāresponse RCT showing significant relief of intermittent allergic rhinitis symptoms vs placebo.
Daily comfort (3)
- Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 15611396
Doseādependent clinically meaningful AR symptom improvement versus placebo.
- Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis
PubMed ID: 11799030
Patientāreported outcomes improved similarly to cetirizineātranslates to better daytime comfort.
- Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339
PubMed ID: 16114089
Large multicenter trial showed significant symptom and global improvements comparable to an antihistamine.
Mucus clearance (2)
- Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339
PubMed ID: 16114089
Large trial demonstrated marked symptomatic improvement versus placebo comparable to standard antihistamine.
- Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 15611396
Doseādependent improvement in AR symptom scores consistent with calmer nasal passages in daily life.
Wellbeing (2)
- Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study
PubMed ID: 15611396
Doseādependent symptom relief in intermittent AR supports improved tolerance of outdoor allergens.
- Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339
PubMed ID: 16114089
Substantial symptomatic improvement comparable to an antihistamine suggests patients could better tolerate outdoor exposures.
Respiratory comfort (1)
- Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339
PubMed ID: 16114089
Large AR trial improved nasal symptom scores which relate to breathing comfort.
Similar by evidence
Supplements the same benefits carry qualifying findings for ā a fact about the evidence graph, not a recommendation to swap.
Products with Butterbur
Search all11 products whose verified label declares Butterbur ā not every bottle that mentions it in a title.