Spermidine
11 benefits mapped to clinical evidence across supplements.
Dose per serving from products
34 products in our catalogue print how much Spermidine a serving holds.
Most common: 1 mg to 2.5 mg and 50 mg to 100 mg, 18% of 34 products each.
| Dose per serving | Products |
|---|---|
| 500 mcg or less | 1 |
| 500 mcg to 1 mg | 4 |
| 1 mg to 2.5 mg | 6 |
| 2.5 mg to 5 mg | 3 |
| 5 mg to 10 mg | 5 |
| 10 mg to 25 mg | 3 |
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 6 |
| 100 mg to 250 mg | 1 |
| over 250 mg | 1 |
Benefit Evidence
Polyamines up in gut
Transit/function changes
Colorectal risk biomarker shift
Research sources
Skin health (5)
- Modulation of biologic endpoints by topical difluoromethylornithine (DFMO), in subjects at high-risk for nonmelanoma skin cancer
PubMed ID: 11801552
Topical DFMO reduced skin spermidine and decreased p53‑positive cells in precancerous lesions—biologic skin benefit.
- Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine
PubMed ID: 11142412
Topical DFMO lowered skin spermidine and reduced actinic keratoses count (~23.5%)—clear local clinical and biochemical skin benefit.
- Reproducibility and expression of skin biomarkers in sun-damaged skin and actinic keratoses
PubMed ID: 17021352
Observational biomarker study: spermidine/putrescine elevated in sun‑damaged skin and AKs—supports spermidine relevance to skin lesion biology.
- A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer
PubMed ID: 20051371
Large RCT: oral DFMO lowered skin ODC and tissue polyamines and was associated with fewer basal cell carcinomas—clinically meaningful skin outcomes.
- New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies
PubMed ID: 29766701
Controlled trial: lotion with a spermidine analogue reduced hair shedding and improved hair growth parameters—topical spermidine‑class benefit for skin appendages.
Gut health (4)
- Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma
PubMed ID: 20538001
DFMO+sulindac trial: early and substantial lowering of rectal mucosal polyamines that predicted adenoma prevention—strong gut biomarker/clinical link.
- Endothelial Function is improved by Inducing Microbial Polyamine Production in the Gut: A Randomized Placebo-Controlled Trial
PubMed ID: 31137855
Intervention increased colonic putrescine and serum spermidine while improving endothelial function—direct gut polyamine modulation in humans.
- Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial
PubMed ID: 40880481
In CKD patients, lubiprostone altered microbiota and was associated with higher plasma spermidine in responders—supports a microbiome→polyamine gut axis.
- Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial
PubMed ID: 36655542
Cinnamon extract RCT increased fecal spermidine and altered colonic transit and metabolites—direct gut microbiome/metabolite evidence.
Cell health (4)
- The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
PubMed ID: 33211152
Fortified rolls raised serum spermidine and improved cognitive performance—supports neurorepair/maintenance implications.
- The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
PubMed ID: 30388439
Spermidine‑rich supplement improved memory in older adults; spermidine is linked mechanistically to autophagy/cellular repair—clinical cognitive signal.
- Roles of spermine in modulating the antioxidant status and Nrf2 signalling molecules expression in the thymus and spleen of suckling piglets-new insight
PubMed ID: 28503850
Spermine in piglets increased antioxidant enzymes and Nrf2 pathway genes—supports cellular protective/repair pathways (animal data).
- Endothelial Function is improved by Inducing Microbial Polyamine Production in the Gut: A Randomized Placebo-Controlled Trial
PubMed ID: 31137855
Microbiome/arginine intervention raised blood spermidine and improved endothelial function—vascular tissue repair implication.
Detoxification (3)
- The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
PubMed ID: 30388439
Spermidine supplement trial for SCD used because spermidine promotes autophagy; observed cognitive gains support cellular‑cleanup‑related benefits.
- Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma
PubMed ID: 20538001
DFMO+sulindac drastically altered mucosal polyamines and reduced adenoma risk—evidence that manipulating polyamines changes tissue turnover/clearance relevant to 'cleanup'.
- The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
PubMed ID: 33211152
Fortified‑roll RCT showed cognitive improvement alongside serum spermidine rises—consistent with autophagy‑mediated maintenance.
Healthy aging (3)
- The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
PubMed ID: 30388439
3‑month randomized spermidine‑rich supplement produced modest improvements in specific memory measures in older adults—clinical aging‑related cognition signal.
- The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
PubMed ID: 33211152
3‑month fortified‑roll RCT in older adults: dose‑dependent serum spermidine rise and improved cognitive scores, relevant to healthy aging.
- Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial
PubMed ID: 40880481
Microbiome-driven increase in polyamines (spermidine) associated with preserved eGFR over 24 weeks—potential geroprotective/organ-preserving signal.
Heart health (2)
- Endothelial Function is improved by Inducing Microbial Polyamine Production in the Gut: A Randomized Placebo-Controlled Trial
PubMed ID: 31137855
RCT: yogurt + B. animalis + arginine raised serum spermidine and improved endothelial function (RHI), directly relevant to heart/vascular health.
- Effects of arginine supplementation during early gestation (day 1 to 30) on litter size and plasma metabolites in gilts and sows
PubMed ID: 26641049
Pregnant‑pig study: dietary arginine raised plasma spermidine and NO metabolites—mechanistic signal for vascular/heart effects (animal data).
Vascular health (2)
- Endothelial Function is improved by Inducing Microbial Polyamine Production in the Gut: A Randomized Placebo-Controlled Trial
PubMed ID: 31137855
Placebo‑controlled trial: intervention raised serum spermidine and improved endothelial RHI—direct evidence for vascular benefit.
- Effects of arginine supplementation during early gestation (day 1 to 30) on litter size and plasma metabolites in gilts and sows
PubMed ID: 26641049
Arginine feeding increased NO and plasma spermidine in pigs—NO is a key vasodilator; animal evidence for vascular effects.
Focus & concentration (2)
- The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
PubMed ID: 30388439
3‑month spermidine‑rich supplement modestly improved mnemonic measures in older adults (pilot RCT).
- The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
PubMed ID: 33211152
Randomized trial in older adults: fortified rolls increased serum spermidine and significantly improved CERAD cognitive scores.
Mental clarity (2)
- The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
PubMed ID: 30388439
Pilot RCT showed medium‑sized mnemonic benefits with spermidine‑rich extract—clinical signal for sharper memory function.
- The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial
PubMed ID: 33211152
Cognitive test improvements in older adults after dietary spermidine fortification—supports improved mental sharpness.
Immune support (1)
- Roles of spermine in modulating the antioxidant status and Nrf2 signalling molecules expression in the thymus and spleen of suckling piglets-new insight
PubMed ID: 28503850
Spermine supplementation in piglets improved antioxidant defenses and upregulated protective/immune genes in immune organs (animal data).
Inflammation (1)
- Roles of spermine in modulating the antioxidant status and Nrf2 signalling molecules expression in the thymus and spleen of suckling piglets-new insight
PubMed ID: 28503850
Spermine supplementation in piglets decreased lipid peroxidation and increased antioxidant enzymes—anti‑inflammatory/oxidative stress modulation (animal data).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Spermidine
Search all62 products whose verified label declares Spermidine — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.