Papain
3 benefits mapped to clinical evidence across supplements.
Dose per serving from products
712 products in our catalogue print how much Papain a serving holds.
Most common: 25 mg to 50 mg, 40% of 712 products.
| Dose per serving | Products |
|---|---|
| 1 mg or less | 9 |
| 1 mg to 2.5 mg | 38 |
| 2.5 mg to 5 mg | 12 |
| 5 mg to 10 mg | 52 |
| 10 mg to 25 mg | 146 |
| 25 mg to 50 mg | 284 |
| 50 mg to 100 mg | 92 |
| 100 mg to 250 mg | 64 |
| over 250 mg | 15 |
Benefit Evidence
Research sources
Pain relief (5)
- Volumetric analysis after caries excavation with caries detecting dyes and chemomechanical caries removal agents using 3D scanner-a randomised clinical trial
PubMed ID: 38302932
Brix3000 papain gel produced much higher painless rates vs rotary instrumentation (large RCT with 3D measures).
- One-year clinical and radiographic evaluation of young permanent molars treated with brix 3000 vs. papacárie duo: a randomized controlled clinical trial
PubMed ID: 40988041
Large randomized trial: papain CMCR markedly lowered pain scores vs hand excavation (and improved painless cases), strong clinical evidence.
- Clinical performance of two chemomechanical caries removal agents in primary molars: a randomized controlled trial
PubMed ID: 40205159
Split‑mouth RCT: papain gels substantially reduced pain and improved behaviour vs conventional methods (but took longer).
- Effect of Papacarie and Alternative Restorative Treatment on Pain Reaction during Caries Removal among Children: A Randomized Controlled Clinical Trial
PubMed ID: 28422591
Randomized trial in children: Papacarie produced substantially and significantly less observed pain vs ART.
- Clinical and Microbiological Analysis of Mechanical and Chemomechanical Methods of Caries Removal in Deciduous Teeth
PubMed ID: 31209448
Papacárie associated with low anesthesia use (14%) and high acceptability—indirect evidence of lower procedure pain.
Skin repair (3)
- The role of Wobe-Mugos in reducing acute sequele of radiation in head and neck cancers--a clinical phase-III randomized trial
PubMed ID: 10921218
Oral enzyme preparation markedly reduced mucositis and skin reactions during radiotherapy, implying faster/less severe skin recovery.
- Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects
PubMed ID: 11561869
Cervical cancer trial showed lower skin reaction scores with enzyme therapy.
- Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers
PubMed ID: 11561868
Significant reductions in mucositis and skin reactions with enzymes during head & neck RT.
Oral health (2)
- The role of Wobe-Mugos in reducing acute sequele of radiation in head and neck cancers--a clinical phase-III randomized trial
PubMed ID: 10921218
Oral enzyme therapy markedly reduced mucositis (oral mucosal injury) during RT, indicating improved oral mucosal health.
- One-year clinical and radiographic evaluation of young permanent molars treated with brix 3000 vs. papacárie duo: a randomized controlled clinical trial
PubMed ID: 40988041
Large trial: papain CMCR produced large reductions in S. mutans/Lactobacilli vs ART, which could benefit overall oral microbial balance relevant to periodontal health (indirect).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Papain
Search all2452 products whose verified label declares Papain — not every bottle that mentions it in a title.