Pantothenic Acid
11 benefits mapped to clinical evidence across supplements.
Dose per serving from products
13,844 products in our catalogue print how much Pantothenic Acid a serving holds.
Most common: 5 mg to 10 mg, 25% of 13,844 products.
| Dose per serving | Products |
|---|---|
| 1 mg or less | 679 |
| 1 mg to 2.5 mg | 1,157 |
| 2.5 mg to 5 mg | 2,507 |
| 5 mg to 10 mg | 3,525 |
| 10 mg to 25 mg | 2,301 |
| 25 mg to 50 mg | 1,595 |
| 50 mg to 100 mg | 1,152 |
| 100 mg to 250 mg | 557 |
| over 250 mg | 371 |
Benefit Evidence
Barrier repair + hydration
Pain/redness reduction + faster healing
Barrier repair + hydration
Pain/redness healing +50%
B5 bioavailability, +18% ORAC
Transient antioxidant boost
Lipids down: LDL/TC
B5 up, eye AEs
Gene shifts; wound healing
Pantothenate -83%; pantetheine +1250%
Faster repair, less redness
Pain/reaction drop, healing up
Barrier repair + hydration
Pain/redness reduction + faster healing
Barrier repair + hydration
Pain/redness healing +50%
B5 bioavailability, +18% ORAC
Transient antioxidant boost
Lipids down: LDL/TC
B5 up, eye AEs
Gene shifts; wound healing
Pantothenate -83%; pantetheine +1250%
Faster repair, less redness
Pain/reaction drop, healing up
Research sources
Skin repair (14)
- Topical Ectoin Versus Topical Dexpanthenol for Managing Acute Radiodermatitis Associated With Breast Cancer Radiotherapy: A Randomized Double-Blind Study
PubMed ID: 37792331
Topical dexpanthenol helped prevent severe radiation dermatitis (though was inferior to ectoin on some symptoms) — supportive of wound/skin protection.
- [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis]
PubMed ID: 12717602
Large RCT: xylometazoline+dexpanthenol superior to xylometazoline alone for mucosal symptoms—supports mucosal healing/repair.
- Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study
PubMed ID: 17128840
Dexpanthenol+zinc oxide ointment reduced TEWL faster and showed modest early lesion improvement in diaper dermatitis.
- Efficacy of dexpanthenol for pediatric post-tonsillectomy pain and wound healing
PubMed ID: 23951700
Randomized trial: dexpanthenol after tonsillectomy reduced throat pain and improved wound healing vs placebo — direct clinical wound support.
- Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery
PubMed ID: 26471464
Oral panthenol gel reduced pain/inflammation and improved healing after third‑molar extraction versus control.
- A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
PubMed ID: 27425824
Panthenol emollient improved barrier repair and hydration, supporting epidermal repair mechanisms.
- A new topical panthenol-containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicenter prospective study
PubMed ID: 28511614
Maintenance emollient with panthenol reduced flares in atopic dermatitis, implying reparative/maintenance effects.
- Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO(2) laser resurfacing of photo-damaged skin in a randomized prospective clinical trial
PubMed ID: 30897983
Topical dexpanthenol accelerated re‑epithelialization after fractional CO2 laser and improved early cosmetic outcomes versus petrolatum.
- Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
PubMed ID: 32683390
Topical gel containing dexpanthenol (with other actives) significantly improved wound healing and reduced pain after lower third molar extraction.
- Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds
PubMed ID: 40327581
Topical panthenol balm performed comparably to an antimicrobial in lesion healing after cryotherapy, supporting skin repair capability.
- Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
PubMed ID: 40613435
Panthenol‑enriched mask significantly improved barrier function and hydration and reduced erythema after laser, consistent with enhanced skin repair.
- [Clinical study of the effectiveness of a dexpanthenol containing artificial tears solution (Siccaprotect) in treatment of dry eyes]
PubMed ID: 8992089
Dexpanthenol eye drops improved corneal epithelial permeability in dry eye patients—benefit for epithelial integrity.
- [Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior]
PubMed ID: 9795928
Dexpanthenol nasal spray reduced crusting and improved breathing in rhinitis sicca—benefit for nasal mucosal repair.
- [Improving wound healing after nose surgery by combined administration of xylometazoline and dexpanthenol]
PubMed ID: 10763172
Adding dexpanthenol to xylometazoline improved postoperative nasal symptoms versus xylometazoline alone—supports mucosal/epithelial recovery.
Skin health (10)
- A new topical panthenol-containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicenter prospective study
PubMed ID: 28511614
Panthenol‑containing emollient was safe and helped maintain low atopic dermatitis activity, reducing flares vs reference.
- A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
PubMed ID: 27425824
Panthenol‑containing emollient produced robust improvements in barrier function and hydration in randomized intra‑individual trials.
- The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial
PubMed ID: 20061726
Topical lotion containing panthenol produced significant skin-tone and texture benefits in a randomized human trial, albeit with other actives present.
- Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study
PubMed ID: 17128840
Dexpanthenol+zinc oxide ointment reduced TEWL faster and gave modestly better early healing in diaper dermatitis (pediatric intraindividual trial).
- Randomised trial on performance, safety and clinical benefit of hyaluronic acid, hyaluronic acid plus dexpanthenol and isotonic saline nasal sprays in patients suffering from dry nose symptoms
PubMed ID: 32067777
Hyaluronic acid + dexpanthenol spray produced greater perceived moisturisation in dry nose patients versus other sprays.
- A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
PubMed ID: 33865303
Moisturizer containing 5% dexpanthenol produced greater clinical improvement in atopic dermatitis vs 5% urea cream.
- Topical Ectoin Versus Topical Dexpanthenol for Managing Acute Radiodermatitis Associated With Breast Cancer Radiotherapy: A Randomized Double-Blind Study
PubMed ID: 37792331
Dexpanthenol cream reduced radiodermatitis relative to baseline though ectoin performed better in this trial.
- The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color
PubMed ID: 33938432
Combination serum including dexpanthenol improved post‑acne hyperpigmentation and skin appearance in darker‑skinned patients.
- Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
PubMed ID: 40613435
Panthenol‑enriched facial mask produced clear, significant improvements in hydration, barrier function and reduced redness after laser.
- Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds
PubMed ID: 40327581
Topical panthenol was an active in a repairing balm that produced equivalent wound‑healing outcomes to standard care, supporting skin health.
Nutrient uptake (6)
- Evaluation of egg injection method of pantothenic acid in turkey eggs and effect of supplemental pantothenic acid on hatchability
PubMed ID: 8234134
Dietary pantothenic acid in hens increased transfer of vitamin B5 into eggs (clear effect on nutrient distribution).
- Effects of high-level dietary B-vitamins on performance, body composition and tissue vitamin contents of growing/finishing pigs
PubMed ID: 17217385
High dietary B‑vitamin raised tissue pantothenic acid concentrations in pigs, demonstrating improved tissue uptake/use.
- [Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus type 2]
PubMed ID: 25300112
Multinutrient supplementation improved serum vitamin status during caloric restriction; supports practical nutrient repletion including pantothenate within a complex formulation.
- Postoperative Vitamin Profile after Receiving a Novel Peripheral Parenteral Nutrition Solution: Multicenter Randomized Controlled Phase III Trial
PubMed ID: 35439754
Multicenter trial showed multivitamin‑containing PPN maintained blood pantothenic acid postoperatively whereas standard PPN did not—direct evidence about delivery/maintenance of pantothenate status.
- Comparison of the Acute Postprandial Circulating B-Vitamin and Vitamer Responses to Single Breakfast Meals in Young and Older Individuals: Preliminary Secondary Outcomes of a Randomized Controlled Trial
PubMed ID: 31795162
Postprandial kinetics study found no acute plasma pantothenate rise after meals, providing direct data on pantothenic acid bioavailability/kinetics.
- Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers
PubMed ID: 40952900
Phase‑1 pharmacodynamic study directly manipulated vanin‑mediated pantothenate production causing massive changes in pantothenate/pantetheine—strong mechanistic evidence on pantothenate handling.
Skin hydration (6)
- Cream versus ointment: Randomized single-blinded study on the adherence to treatment with topical methylprednisolone aceponate
PubMed ID: 37960922
Panthenol emollient used in eczema improved clinical scores (emollient effect on hydration/barrier) though study focused on vehicle adherence.
- A new topical panthenol-containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicenter prospective study
PubMed ID: 28511614
Panthenol‑containing emollient helped maintain control of mild atopic dermatitis in children and is consistent with maintaining skin hydration.
- Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study
PubMed ID: 17128840
Diaper dermatitis trial: dexpanthenol+zinc sped early TEWL recovery and increased early clearance vs base.
- A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
PubMed ID: 27425824
Randomized trial: panthenol emollient objectively improved TEWL and stratum corneum hydration without harming microflora — strong direct evidence for hydration/barrier benefit.
- Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
PubMed ID: 40613435
Randomized double‑blind trial: panthenol‑enriched mask significantly improved TEWL and stratum corneum hydration post‑laser vs control.
- A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
PubMed ID: 33865303
Moisturizer with dexpanthenol + lipids reduced SCORAD more than urea cream and increased hydration (combination product).
Hair & Nails (3)
- Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, double-blind controlled study comparing two brands
PubMed ID: 35791704
Weekly intramuscular biotin + dexpanthenol injections improved hair fall count and hair density versus baseline; dexpanthenol used in combination (no placebo arm).
- [The efficacy of drug therapy in structural lesions of the hair and in diffuse effluvium--comparative double blind study]
PubMed ID: 1709511
Pantogar (multi‑ingredient including pantothenic acid) improved hair swelling/thickness/density vs placebo in a randomized trial (direct hair outcome; multi‑ingredient).
- [Systemic therapy of diffuse effluvium and hair structure damage]
PubMed ID: 7687592
Two vitamin/L‑cystine formulations including B‑vitamins improved hair measures vs placebo (benefit observed but multi‑ingredient confounding).
Metabolism (3)
- Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation
PubMed ID: 21925346
Pantethine modestly lowered TC, LDL and ApoB versus placebo in diet-controlled adults—supports a metabolic/lipid effect attributable to a B5 derivative.
- Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation
PubMed ID: 24600231
Pantethine (a B5 derivative) on top of diet produced consistent LDL and total cholesterol reductions over 16 weeks—evidence for metabolic/ lipid effects.
- Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers
PubMed ID: 40952900
Vanin inhibitor produced profound, dose‑dependent reductions in pantothenic acid and large pantetheine changes, directly demonstrating impact on B5 metabolic pathways (mechanistic evidence).
Exercise recovery (3)
- Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO(2) laser resurfacing of photo-damaged skin in a randomized prospective clinical trial
PubMed ID: 30897983
Topical dexpanthenol accelerated early wound closure and improved early cosmetic scores after CO2 laser—faster local recovery demonstrated.
- Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery
PubMed ID: 26471464
Oral panthenol gel reduced pain and swelling and improved healing after wisdom tooth extraction, indicating faster recovery from a surgical insult.
- Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
PubMed ID: 32683390
Multi‑ingredient gel containing dexpanthenol improved wound healing and reduced pain post‑extraction versus placebo.
Cell health (3)
- Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers
PubMed ID: 40952900
Phase‑1 trial of a vanin inhibitor produced large, dose‑related changes in pantothenate/pantetheine pools, showing major impact on cellular pantothenate metabolism and raising safety considerations.
- Efficacy of dexpanthenol for pediatric post-tonsillectomy pain and wound healing
PubMed ID: 23951700
Clinically faster mucosal wound healing and less pain after tonsillectomy with dexpanthenol indicates enhanced cellular repair in epithelial tissue.
- Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO(2) laser resurfacing of photo-damaged skin in a randomized prospective clinical trial
PubMed ID: 30897983
Dexpanthenol accelerated re‑epithelialization after laser resurfacing, indicating stimulation of cellular repair processes.
Cholesterol (2)
- Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation
PubMed ID: 21925346
Pantethine produced modest but statistically significant reductions in TC, LDL-C and ApoB vs placebo in diet-controlled adults—supports cholesterol-lowering potential.
- Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation
PubMed ID: 24600231
Pantethine (a vitamin B5 derivative) significantly lowered LDL-C (~11%) and total cholesterol over 16 weeks on top of diet—consistent evidence of cholesterol benefit.
Digestive support (1)
- Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat
PubMed ID: 17073853
Dexpanthenol pastilles significantly reduced postoperative sore throat versus spray/placebo—direct mucosal benefit in the oropharynx.
Vitality (1)
- [Use of natural vitamin supplements in children during convalescence and in children with athletic activities]
PubMed ID: 10356941
Multi‑vitamin (including B5) raised B5 and improved appetite, weight and strength in convalescent children (multi‑ingredient, plausible contribution).
Forms of Pantothenic Acid
The form a label may print instead of Pantothenic Acid. Each is a different substance with its own identifier, and none of them has research of its own — the studies are the ones on this page.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Pantothenic Acid
Search all15752 products whose verified label declares Pantothenic Acid — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.