Naringenin
6 benefits mapped to clinical evidence across supplements.
Benefit Evidence
Research sources
Heart health (3)
- Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: a randomized, controlled, crossover trial
PubMed ID: 26016866
6‑month grapefruit juice RCT modestly reduced central aortic stiffness—cardiovascular benefit.
- Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 34860705
Pilot RCT in NAFLD patients showed improvements in atherogenic indices and non‑HDL‑C versus placebo, indicating favorable effects on cardiovascular risk markers.
- Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial
PubMed ID: 41408634
Large prospective biomarker study found a naringenin‑containing polyphenol signature inversely associated with future cardiovascular events (HRs significant), supporting cardioprotective association.
Liver support (3)
- Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial
PubMed ID: 34516703
Randomized double‑blind RCT: 200 mg/day naringenin for 4 weeks reduced liver steatosis grades and improved TG and LDL in overweight NAFLD patients.
- Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial
PubMed ID: 33461965
Large dietary trial (green‑MED) raised plasma naringenin detection and produced larger intrahepatic fat reductions versus controls (indirect but supportive).
- Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 34860705
4‑week RCT in overweight/obese NAFLD patients reported improved lipid risk markers and reductions in BMI/visceral fat, implying potential benefit for fatty liver (indirect clinical evidence).
Immune support (2)
- An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis
PubMed ID: 17519582
RCT: oral tomato extract (contains naringenin) reduced sneezing and overall nasal symptoms in perennial allergic rhinitis.
- The therapeutic effects of naringenin on bronchial pneumonia in children
PubMed ID: 34310866
Randomized pediatric RCT showed large reductions in pro‑inflammatory cytokines (IL‑6, IL‑8) and increased IL‑10, indicating strong immunomodulatory/anti‑inflammatory effects.
Cholesterol (2)
- Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial
PubMed ID: 34516703
200 mg/day naringenin for 4 weeks lowered triglycerides and LDL in overweight NAFLD patients (RCT evidence).
- Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 34860705
Pilot RCT demonstrated significant reductions in atherogenic index and non‑HDL‑C versus placebo, supporting beneficial effects on cholesterol risk markers.
Inflammation (1)
- The therapeutic effects of naringenin on bronchial pneumonia in children
PubMed ID: 34310866
Strong randomized pediatric trial demonstrated marked reductions in IL‑6 and IL‑8 and a large rise in anti‑inflammatory IL‑10 with clinical recovery—clear anti‑inflammatory effect.
Weight management (1)
- Effects of naringenin supplementation on cardiovascular risk factors in overweight/obese patients with nonalcoholic fatty liver disease: a pilot double-blind, placebo-controlled, randomized clinical trial
PubMed ID: 34860705
Pilot RCT reported significant reductions in BMI and visceral fat versus placebo over 4 weeks in overweight/obese NAFLD patients (small, short trial but direct clinical effect).
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Naringenin
Search all7 products whose verified label declares Naringenin — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.