Green Lipped Mussel
6 benefits mapped to clinical evidence across supplements.
Dose per serving from research
7 study groups in 4 studies say how much Green Lipped Mussel participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 g to 5 g and 10 g to 25 g, 29% of 7 study groups each.
| Daily dose | Study groups |
|---|---|
| 500 mg or less | 1 |
| 500 mg to 1 g | 0 |
| 1 g to 2.5 g | 1 |
| 2.5 g to 5 g | 2 |
| 5 g to 10 g | 0 |
| 10 g to 25 g | 2 |
| 25 g to 50 g | 0 |
| 50 g to 100 g | 0 |
| over 100 g | 1 |
Benefit Evidence
Research sources
Joint comfort (6)
- Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs
PubMed ID: 15136981
Related/duplicate report of the same canine benefit data showing improved arthritis signs.
- Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease
PubMed ID: 16751841
Dogs with DJD showed a higher rate of clinical improvement vs placebo after GLM extract.
- Evaluation of a therapeutic diet for feline degenerative joint disease
PubMed ID: 20337921
Diet containing GSM extract (with EPA/DHA + glucosamine/chondroitin) increased activity and improved mobility in cats with DJD.
- Perna canaliculus lipid complex PCSO-524⢠demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control
PubMed ID: 23739042
PCSOâ524⢠produced large, clinically meaningful pain and function improvements in older adults with OA vs fish oil.
- Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles
PubMed ID: 22821424
GLM improved WOMAC/Lequesne OA symptom scores over 12 weeks (clinical symptom improvement).
- Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs
PubMed ID: 19753702
Doubleâblind canine trial: dietary GLM reduced total arthritis scores and improved pain/swelling.
Healthy aging (5)
- Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease
PubMed ID: 16751841
Dogs with DJD had higher improvement rates with GLME vs placebo by Day 56âevidence for benefit in degenerative (aging) joints.
- Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs
PubMed ID: 19753702
Canine trial showed arthritis sign reductions with dietary GLMârelevant to aging joint care though animal data.
- Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles
PubMed ID: 22821424
Symptom improvements with GLM in knee OA indicate support for degenerative joint conditions.
- Perna canaliculus lipid complex PCSO-524⢠demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control
PubMed ID: 23739042
PCSOâ524⢠produced marked pain and function improvements in older adults with OAâstrong clinical signal for supporting aging joints.
- Evaluation of a therapeutic diet for feline degenerative joint disease
PubMed ID: 20337921
GSMâcontaining diet improved mobility in older animals with degenerative joint diseaseâsupports aging joint function.
Joint mobility (5)
- Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles
PubMed ID: 22821424
Symptom score improvements with GLM suggest better movement in knee OA subjects.
- Perna canaliculus lipid complex PCSO-524⢠demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control
PubMed ID: 23739042
Marked reductions in pain and improved function in OA patients on PCSOâ524⢠indicate easier movement.
- Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease
PubMed ID: 16751841
Higher proportion of dogs improved clinically on GLME vs placeboâsupports better movement.
- Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs
PubMed ID: 19753702
Canine data show improved clinical arthritis signs consistent with easier movement.
- Evaluation of a therapeutic diet for feline degenerative joint disease
PubMed ID: 20337921
Accelerometer data in cats showed a clear and significant increase in physical activity and mobility with GLM diet.
Inflammation (3)
- Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial
PubMed ID: 12358334
LyprinolÂŽ reduced exhaled H2O2 (airway oxidative/inflammatory marker) in asthmatics.
- Perna canaliculus lipid complex PCSO-524⢠demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control
PubMed ID: 23739042
Rapid clinical improvements in OA with PCSOâ524⢠are consistent with antiâinflammatory action.
- Evaluation of a therapeutic diet for feline degenerative joint disease
PubMed ID: 20337921
Improved mobility and pain in cats on GLM diet are consistent with reduced inflammatory joint burden.
Immune support (2)
- Perna canaliculus lipid complex PCSO-524⢠demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control
PubMed ID: 23739042
PCSOâ524⢠produced clinical improvements in OA and has plausible immunomodulatory/antiâinflammatory effects reported.
- Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial
PubMed ID: 12358334
LyprinolÂŽ reduced wheeze and exhaled H2O2 and improved PEF in steroidânaĂŻve atopic asthmaâevidence of immune/airway anti-inflammatory action.
Stress resilience (1)
- Evaluation of a therapeutic diet for feline degenerative joint disease
PubMed ID: 20337921
Increased activity and mobility in cats suggests greater functional resilience to joint disease.
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Green Lipped Mussel
Search all7 products whose verified label declares Green Lipped Mussel â not every bottle that mentions it in a title.