Nattokinase
5 benefits mapped to clinical evidence across supplements.
Dose per serving from products
275 products in our catalogue print how much Nattokinase a serving holds.
Most common: 50 mg to 100 mg, 36% of 275 products.
| Dose per serving | Products |
|---|---|
| 10 mg or less | 5 |
| 10 mg to 25 mg | 17 |
| 25 mg to 50 mg | 11 |
| 50 mg to 100 mg | 100 |
| 100 mg to 250 mg | 78 |
| 250 mg to 500 mg | 42 |
| 500 mg to 1 g | 21 |
| over 1 g | 1 |
Benefit Evidence
Research sources
Blood circulation (4)
- Prevention of venous thrombosis in long-haul flights with Flite Tabs: the LONFLIT-FLITE randomized, controlled trial
PubMed ID: 14565628
Large randomized trial in long-haul passengers found reduced asymptomatic DVTs and edema with an oral profibrinolytic (Flite Tabs) — directly relevant to travel circulation (product not nattokinase).
- Effects of nattokinase on blood pressure: a randomized, controlled trial
PubMed ID: 18971533
BP reduction and lowered renin activity in RCT provide support for improved circulatory health.
- Nattospes as Effective and Safe Functional Supplements in Management of Stroke
PubMed ID: 31934821
Stroke rehabilitation study using a nattokinase-containing supplement correlated with greater functional recovery — suggests possible cerebral perfusion/repair benefit albeit confounded.
- The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects
PubMed ID: 31070609
Prolonged PT/aPTT and platelet-closure time indicate reduced coagulability and blood 'thickness'.
Heart health (2)
- Effects of nattokinase on blood pressure: a randomized, controlled trial
PubMed ID: 18971533
Randomized RCT showed modest but significant SBP/DBP reductions, relevant to heart health.
- The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects
PubMed ID: 31070609
8-week trial showed prolonged platelet-collagen closure time, PT and aPTT — strong evidence of anticoagulant/antiplatelet effects.
Cholesterol (2)
- The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial
PubMed ID: 37836525
Nattokinase+RYR product produced significant LDL/TC/non-HDL reductions; likely substantially RYR-driven but trial used nattokinase-containing formula.
- Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia
PubMed ID: 19786378
Combined nattokinase+red yeast rice markedly lowered TG/TC/LDL but changes likely driven by red yeast rice (monacolin K); relevance to nattokinase alone limited.
Blood pressure (1)
- Effects of nattokinase on blood pressure: a randomized, controlled trial
PubMed ID: 18971533
Double-blind RCT showed modest but significant reductions in SBP and DBP over 8 weeks.
Vascular health (1)
- Effects of nattokinase on blood pressure: a randomized, controlled trial
PubMed ID: 18971533
BP reductions and lowered renin activity may reflect modest favorable vascular effects potentially linked to improved flexibility.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Nattokinase
Search all475 products whose verified label declares Nattokinase — not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet — this is what the field is asking, not what it found.