Glycerol
5 benefits mapped to clinical evidence across supplements.
Dose per serving from products
57 products in our catalogue print how much Glycerol a serving holds.
Most common: 5 g to 10 g, 30% of 57 products.
| Dose per serving | Products |
|---|---|
| 25 mg or less | 3 |
| 25 mg to 50 mg | 2 |
| 50 mg to 100 mg | 1 |
| 100 mg to 250 mg | 2 |
| 250 mg to 500 mg | 1 |
| 500 mg to 1 g | 5 |
| 1 g to 2.5 g | 10 |
| 2.5 g to 5 g | 8 |
| 5 g to 10 g | 17 |
| 10 g to 25 g | 8 |
Benefit Evidence
Endurance +21â25%, HRâ
Fluid retention/plasma volumeâ
Time-to-exhaustion, mass lossâ
Endurance +21â25%, HRâ
Fluid retention/plasma volumeâ
Time-to-exhaustion, mass lossâ
Research sources
Skin hydration (34)
- A comparison of dioctahedral smectite and iodine glycerin cream with topical mouth rinse in treatment of chemotherapy induced oral mucositis: a pilot study
PubMed ID: 25465773
Topical iodineâglycerin cream markedly reduced oral mucositis severity and accelerated repairâconsistent with glycerin's moisture/soothing action on mucosa.
- Ventilator-associated pneumonia risk decreased by use of oral moisture gel in oral health care
PubMed ID: 24965954
Oral moisture gel (likely glycerin-containing) decreased cuff contamination and reduced care time, indicating effective local moisturization properties.
- Randomised controlled trial of topical kanuka honey for the treatment of rosacea
PubMed ID: 26109117
Topical study: a medical product containing 10% glycerine improved rosacea severity and patient-rated outcomes versus control creamâsupports benefit of glycerine-containing topical formulations on skin condition.
- A randomized controlled trial to evaluate the effect of a new skincare regimen on skin barrier function in those with podoconiosis in Ethiopia
PubMed ID: 28374907
Large randomized trial: 2% glycerol foot soaks significantly improved stratum corneum hydration and reduced TEWL with clinical improvements.
- Prevention of Flares in Children with Atopic Dermatitis with Regular Use of an Emollient Containing Glycerol and Paraffin: A Randomized Controlled Study
PubMed ID: 28271540
Large RCT in children: regular use of glycerolâcontaining emollient reduced flares and steroid need â demonstrates sustained skin barrier/hydration benefits.
- Efficacy of an emollient cream in the treatment of xerosis in diabetic foot: a double-blind, randomized, vehicle-controlled clinical trial
PubMed ID: 27997725
Randomized contralateral trial: glycerolâcontaining emollient improved diabetic foot hydration and xerosis vs vehicle.
- Evaluation of an enhanced viscosity artificial tear for moderate to severe dry eye disease: A multicenter, double-masked, randomized 30-day study
PubMed ID: 30573298
Artificial tear with 0.9% glycerin produced earlier symptom improvement and some objective tear/ocular surface benefits â supports mucosal/ocular hydration.
- Effects of 3 Different Methods of Care on the Peristomal Skin Integrity of Children with Percutaneous Endoscopic Gastrostomy Tubes: A Prospective Randomized Controlled Trial
PubMed ID: 29561342
Randomized pediatric trial: glycerin hydrogel maintained peristomal moisture and reduced dressing changes â clear topical moisture benefit.
- Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
PubMed ID: 31532576
Strong randomized evidence that a petrolatum+glycerol emollient significantly increased skin hydration (corneometry) and improved barrier metrics vs controls.
- Glycerol content within the WHO ethanol-based handrub formulation: balancing tolerability with antimicrobial efficacy
PubMed ID: 31285821
Lowering glycerol in handrub improved skin tolerability; glycerol content modulates skin outcomes in topical antiseptics and moisturizers.
- Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial with clinical and bacteriological evaluation
PubMed ID: 31869257
Topical 85% glycerol improved atopic dermatitis severity in a randomized comparison, consistent with strong moisturization effects.
- Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis
PubMed ID: 35167133
Ureaâglycerol cream markedly improved TEWL, NMF and hydration vs controls in a randomized withinâsubject studyârobust support for glycerol as a moisturizer ingredient.
- Cocos nucifera and glycerine afterwork moisturizers for secondary prevention of hand dermatitis among fabric worker: a randomized, double-blind, cross over trial
PubMed ID: 39237662
Workers using glycerinâcontaining moisturizers showed improved HECSI, TEWL and skin capacitance â clinical benefit on skin hydration.
- Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis
PubMed ID: 40408261
Doubleâblind trial: glycerineâcontaining emollient improved skin hydration, reduced TEWL and increased ceramides â strong direct evidence.
- Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women
PubMed ID: 19743936
Commercial glycerolâcontaining products used as positive controls produced steep increases in stratum corneum moisturization â direct evidence that glycerol formulations rapidly improve skin hydration.
- Glyaderm(ÂŽ) dermal substitute: clinical application and long-term results in 55 patients
PubMed ID: 24946965
Glycerolâpreserved dermal matrix (Glyaderm) produced better scar elasticity and demonstrates beneficial skin/tissue effects from glycerol use in clinical grafts.
- Clinical evidence to demonstrate that simultaneous growth of epithelial and fibroblast cells is essential for deep wound healing
PubMed ID: 21247651
Topical plant-extract treatment used glycerol+honey as vehicle; the glycerol-containing vehicle was present in control and active formulations and is a known humectantâtrial shows strong topical effects though glycerol-specific contribution cannot be isolated.
- Evaluation of the activity and safety of CS21 barrier genital gelÂŽ compared to topical aciclovir and placebo in symptoms of genital herpes recurrences: a randomized clinical trial
PubMed ID: 24010876
Topical oxygenatedâglycerolâtriester gel produced symptomatic improvement and faster healing of genital lesions â strong evidence topical glycerol derivatives enhance barrier/hydration.
- An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial
PubMed ID: 28160585
Topical triester glycerol-oxide gel (a glycerol derivative) improved mucosal ulcer pain/healing; demonstrates topical glycerol-derivative benefit for surface tissue repair/hydration (mucosal rather than skin).
- Short- and Long-Term Effects of a Multi-Component, Artificial Tear on Preocular Tear Film Stability, Tear Evaporation and Tear Film Optical Dynamic: A Prospective Randomized Double-Phase Study
PubMed ID: 35749148
Glycerol-containing artificial tear improved tear film hydration and reduced evaporation â strong evidence of glycerol's humectant, moisture-preserving properties at mucosal surfaces; supports likely utility as a topical moisturizer (high relevance).
- Effect of perineal massage on the rate of episiotomy and perineal tearing
PubMed ID: 26410801
Glycerol applied during perineal massage reduced episiotomy rates, consistent with improved lubrication/moisturization and tissue pliability.
- A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients
PubMed ID: 12013198
A 20% glycerin cream relieved dry atopic skin as effectively as urea cream, with less stingingâdirect clinical evidence for moisturization.
- A randomised clinical trial comparing a hydrocolloid-derived dressing and glycerol preserved allograft skin in the management of partial thickness burns
PubMed ID: 14556729
Glycerol-preserved donor skin improved early skin elasticity and reduced later graft surgeries after burns, supporting beneficial effects on skin quality.
- Ototopical ciprofloxacin in a glycerin vehicle for the treatment of acute external otitis
PubMed ID: 15529649
Ear-drop ciprofloxacin in glycerin vehicle produced faster symptomatic resolution vs aqueous vehicle â supports glycerin as an effective topical vehicle/humectant in mucocutaneous application.
- A randomised controlled trial comparing Triadcortyl with 10% glycerine-ichthammol in the initial treatment of severe acute otitis externa
PubMed ID: 17922130
10% glycerine ear dressing was effective clinicallyâsupports topical glycerineâs local moisturizing/therapeutic activity.
- Efficacy of a new oral lubricant solution in the management of psychotropic drug-induced xerostomia: a randomized controlled trial
PubMed ID: 17873673
Oxygenated glycerol triester oral spray improved oral mucosal dryness and tissue condition vs a saliva substituteâdemonstrates glycerolâs hygroscopic/moisturizing properties on mucosa (analogous to skin).
- Management of xerostomia in older patients : a randomised controlled trial evaluating the efficacy of a new oral lubricant solution
PubMed ID: 17953462
OGT spray improved xerostomia symptoms in elderly patientsâstrong evidence glycerol esters support mucosal hydration; applicable to moisturizing function.
- Efficacy of topical 10% urea-based lotion in patients with ichthyosis vulgaris: a two-center, randomized, controlled, single-blind, right-vs.-left study in comparison with standard glycerol-based emollient cream
PubMed ID: 22007909
Small clinical trial: glycerol cream improved scaling in ichthyosis vulgaris (~40% improvement), indicating moisturization benefit.
- Evaluation of a skin protection cream for dry skin in patients undergoing narrow band UVB phototherapy for psoriasis vulgaris
PubMed ID: 21566547
Randomized study: glycerol-containing cream improved skin hydration and psoriasis-related signs better than vaseline.
- Randomized, double-blind study with glycerol and paraffin in uremic xerosis
PubMed ID: 21258039
Strong randomized intra-individual trial: glycerol+paraffin produced large, clinically meaningful improvements in uremic xerosis vs emulsion alone.
- An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial
PubMed ID: 23009311
Glycerol comparator significantly reduced diabetic foot dryness index (~47% vs baseline) in a human study.
- Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers
PubMed ID: 22206073
Two randomized studies: glycerin-containing moisturizers (with niacinamide) produced superior skin hydration and barrier improvements versus comparators.
- A glycerin hydrogel-based wound dressing prevents peristomal infections after percutaneous endoscopic gastrostomy (PEG): a prospective, randomized study
PubMed ID: 22523159
Glycerin hydrogel dressing reduced peristomal infection and wound reactions and provided a moist wound environment; supports local moisture maintenance.
- Long-term emollient therapy improves xerosis in children with atopic dermatitis
PubMed ID: 24267728
Double-blind randomized trial: glycerol-containing emollient improved xerosis, SCORAD and skin hydration in young children with atopic dermatitis.
Hydration (14)
- Short- and Long-Term Effects of a Multi-Component, Artificial Tear on Preocular Tear Film Stability, Tear Evaporation and Tear Film Optical Dynamic: A Prospective Randomized Double-Phase Study
PubMed ID: 35749148
Glycerol-containing artificial tear substantially improved tear stability and reduced evaporation â clear humectant/hydration effect at ocular surface (supports glycerol's hydration properties).
- Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial with clinical and bacteriological evaluation
PubMed ID: 31869257
Topical 85% glycerol improved atopic dermatitis severity and thus skin hydration in a small randomized comparison.
- A randomized trial modeling the effects of solutions with low to moderate glycerol and sodium concentrations on fluid balance in healthy, active adults
PubMed ID: 41138915
Randomized doseâresponse trial showed that âĽ1.5% glycerol (or modest glycerol+Na) improved fluid retention over 210 min vs placebo â direct, highâquality evidence for hydration.
- Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis
PubMed ID: 35167133
Ureaâglycerol moisturizer markedly improved skin hydration, NMF and reduced TEWL vs controls in a randomized withinâsubject trial.
- Three-phase study of phlebitis in patients receiving peripheral intravenous hyperalimentation
PubMed ID: 2105670
Replacing glucose-based peripheral hyperalimentation with a glycerol-containing IV solution markedly changed infusion tolerance (large clinical effect on phlebitis); indicates clinical utility of glycerol in IV fluids (indirect hydration relevance).
- Comparison of diuretic effects of glycerol with furosemide after transurethral prostatectomy
PubMed ID: 9084545
IV glycerol raised osmolality and produced markedly less immediate urine output versus diuretic control â direct evidence of retained fluid effect.
- Increase in serum osmolality is possible mechanism for the beneficial effects of glycerol in childhood bacterial meningitis
PubMed ID: 18776819
Oral glycerol transiently increased plasma osmolality in children (clinical context), supporting glycerol's osmotic/hydration effects.
- Evaluation of a skin protection cream for dry skin in patients undergoing narrow band UVB phototherapy for psoriasis vulgaris
PubMed ID: 21566547
Glycerol-containing skin cream improved hydration and psoriasis-related skin symptoms vs vaseline (human RCT).
- Randomized, double-blind study with glycerol and paraffin in uremic xerosis
PubMed ID: 21258039
Randomized trial: topical glycerol+paraffin substantially improved skin hydration in uremic xerosis (direct hydration effect).
- An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial
PubMed ID: 23009311
Glycerol cream improved diabetic foot skin hydration albeit less than comparator (human study).
- Effects of 3 Different Methods of Care on the Peristomal Skin Integrity of Children with Percutaneous Endoscopic Gastrostomy Tubes: A Prospective Randomized Controlled Trial
PubMed ID: 29561342
Glycerin hydrogel maintained peristomal moisture and reduced dressing changes â strong evidence for local/moisture maintenance.
- Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
PubMed ID: 31532576
Randomized crossover showed glycerol (with petrolatum) significantly increased skin hydration (corneometry) and lowered TEWL; strong evidence for topical hydration.
- Glycerol content within the WHO ethanol-based handrub formulation: balancing tolerability with antimicrobial efficacy
PubMed ID: 31285821
Lower glycerol concentration (0.5%) in handrub improved skin tolerability vs standard formulation, indicating glycerol influences skin hydration/tolerance.
- A Comparative Study of Bolus Dose of Hypertonic Saline, Mannitol, and Mannitol Plus Glycerol Combination in Patients with Severe Traumatic Brain Injury
PubMed ID: 30684710
Equiosmolar mannitol+glycerol bolus demonstrated significant osmotic effects on intracranial pressure and serum osmolarity, supporting glycerol's role in shifting/holding body fluids in a clinical setting.
Vitality (4)
- Fasting Blood Ammonia Predicts Risk and Frequency of Hepatic Encephalopathy Episodes in Patients With Cirrhosis
PubMed ID: 26707685
Glycerol phenylbutyrate (a glycerol derivative drug) lowered ammonia and reduced hepatic encephalopathy events in cirrhosisâclear clinical benefit likely to improve overall wellbeing/vitality in that population.
- [Evaluation of glycerol in the treatment of cerebral infarction]
PubMed ID: 1658863
Randomized trial in stroke patients reported glycerol improved cerebral edema and clinical outcomes â direct clinical benefit indicating improved patient vitality/function in that context.
- Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate
PubMed ID: 22961727
Long-term glycerol phenylbutyrate in urea-cycle disorder patients improved ammonia control and executive functionâimportant clinical benefits supporting improved overall function/vitality.
- Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy
PubMed ID: 23847109
Glycerol phenylbutyrate (a glycerol-based drug) reduced hepatic encephalopathy events and ammonia in cirrhosisâclinically meaningful health benefits that could increase patient vitality.
Stress resilience (2)
- Clinical Evaluation of NESOSPRAY HE-C, a Nasal Spray, for Rhinopharyngitis and Rhinosinusitis: A Randomized, Double-Blind, Placebo-Controlled Trial
PubMed ID: 40572759
Glycerolâbased filmogenic nasal spray provided rapid symptomatic relief in URTI across populations â could support resilience to upperârespiratory insults relevant to athletes.
- ColdzymeÂŽ Mouth Spray reduces duration of upper respiratory tract infection symptoms in endurance athletes under free living conditions
PubMed ID: 32419645
ColdZyme throat spray with a glycerol matrix shortened URTI duration in endurance athletes, which could improve resilience to infections during athletic seasons.
Joint comfort (2)
- A randomized, double-blind comparison shows the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain demonstrates incremental benefit over time
PubMed ID: 22304620
Topical formulation containing oxygenated glycerol triesters added to menthol produced greater pain relief and improved mobility for musculoskeletal pain.
- A randomized double-blind trial of dextrose-glycerine-phenol injections for chronic, low back pain
PubMed ID: 8439713
Injections containing dextroseâglycerineâphenol reduced pain/disability vs lidocaine in chronic low back painâglycerine was a component of an effective proliferant (combination treatment).
Similar by evidence
Supplements the same benefits carry qualifying findings for â a fact about the evidence graph, not a recommendation to swap.
Products with Glycerol
Search all131 products whose verified label declares Glycerol â not every bottle that mentions it in a title.
Being studied right now
Recruiting clinical trials registered on ClinicalTrials.gov. A trial in progress has no result yet â this is what the field is asking, not what it found.