Birch Bark
3 benefits mapped to clinical evidence across supplements.
Benefit Evidence
Research sources
Skin repair (5)
- Treatment of actinic keratoses with a novel betulin-based oleogel. A prospective, randomized, comparative pilot study
PubMed ID: 18808378
Pilot AK trial: lesion clearance and reduced dysplasia in many patients — supportive for topical lesion/wound effects though small and mixed vs cryo.
- Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program
PubMed ID: 28400148
Phase III program: consistent, statistically significant shortening of time to wound closure (~1.1 days) → strong evidence for wound healing.
- Betulin wound gel accelerated healing of superficial partial thickness burns: Results of a randomized, intra-individually controlled, phase III trial with 12-months follow-up
PubMed ID: 30559054
Intra‑individual phase III burn trial: large, clinically meaningful increase in earlier wound healing (85.7% vs 14.3%) → very strong support.
- OLEOGEL-S10 TO ACCELERATE HEALING OF DONOR SITES: MONOCENTRIC RESULTS OF PHASE III CLINICAL TRIAL
PubMed ID: 29651853
Single‑center phase III: ~1 day faster donor‑site healing and better objective/subjective scar metrics → solid wound care support.
- Long-term safety and efficacy of Oleogel-S10 (birch bark extract) in epidermolysis bullosa: 24-month results from the phase III EASE study
PubMed ID: 39821055
24‑month EB follow‑up: sustained reductions in wound burden and skin activity → meaningful long‑term wound care benefit.
Skin hydration (4)
- Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program
PubMed ID: 28400148
Phase III: statistically faster reepithelialization of donor wounds → meaningful skin healing benefit.
- Betulin wound gel accelerated healing of superficial partial thickness burns: Results of a randomized, intra-individually controlled, phase III trial with 12-months follow-up
PubMed ID: 30559054
Burn study: markedly faster and more frequent earlier healing → improved skin recovery/appearance.
- OLEOGEL-S10 TO ACCELERATE HEALING OF DONOR SITES: MONOCENTRIC RESULTS OF PHASE III CLINICAL TRIAL
PubMed ID: 29651853
Shorter donor‑site healing and better scar/skin measurements (POSAS) → supports skin quality/nourishment.
- Long-term safety and efficacy of Oleogel-S10 (birch bark extract) in epidermolysis bullosa: 24-month results from the phase III EASE study
PubMed ID: 39821055
Long‑term EB follow‑up: sustained reductions in wound burden and skin activity → secondary skin improvement.
Wellbeing (1)
- Long-term safety and efficacy of Oleogel-S10 (birch bark extract) in epidermolysis bullosa: 24-month results from the phase III EASE study
PubMed ID: 39821055
Open‑label long‑term EB data show clinically meaningful reductions in wound burden and disease activity → likely improved well‑being.
Similar by evidence
Supplements the same benefits carry qualifying findings for — a fact about the evidence graph, not a recommendation to swap.
Products with Birch Bark
Search all29 products whose verified label declares Birch Bark — not every bottle that mentions it in a title.