Vitamin A, Zinc and Iron: study protocols
23 study groups took Vitamin A together with Zinc and Iron. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin A
19 study groups in 14 studies say how much Vitamin A participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 47% of 19 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 3 |
| 250 mcg to 500 mcg | 9 |
| 500 mcg to 1 mg | 6 |
| 1 mg to 2.5 mg | 1 |
Dose per serving from research: Zinc
23 study groups in 18 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mg to 5 mg, 35% of 23 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 1 |
| 2.5 mg to 5 mg | 8 |
| 5 mg to 10 mg | 7 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 5 |
Dose per serving from research: Iron
22 study groups in 18 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 50% of 22 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 11 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 3 |
Commonly used together
19 of 23 study groups took Vitamin A, Zinc and Iron with something else. Shown: what 3 or more different studies gave. The 10 most common of 13.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin C | 12 |
| Folic Acid | 10 |
| Vitamin B12 | 8 |
| Copper | 7 |
| Vitamin E | 7 |
| Iodine | 6 |
| Vitamin B6 | 5 |
| Vitamin D | 5 |
| Selenium | 4 |
| Niacin | 3 |
23 study groups
| Study | |||||
|---|---|---|---|---|---|
| Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana 2021 · iron-MNP group · Children aged 6–35 months living in rural Ghana; children with severe anaemia, severe malnutrition, recent iron supplementation, or chronic disease were excluded. | 400 mcg | 5 mg | 12.5 mg | 150 days | 967 |
| Cow's milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT 2016 · CMBB · Children aged 1 to 4 years attending daycare in Brazil; generally healthy, without a stated diagnosed condition | 1,890 IU | 6.9 mg | 9 mg | 28 weeks | 125 |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Folic acid + iron + zinc · Pregnant women in rural Nepal | 1 mg | 30 mg | 60 mg | — | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 1 mg | 30 mg | — | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 1,250 IU | 10 mg | 10 mg | 548 days | — |
| Zinc-iron, but not zinc-alone supplementation, increased linear growth of stunted infants with low haemoglobin 2007 · zinc+iron+vitamin-A · Infants aged 3–6 months in rural East Lombok; the study included infants with stunting and low haemoglobin | 1,000 IU | 10 mg | 10 mg | 26 weeks | — |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 156 mcg | 7.8 mg | 9.6 mg | 1 year | 316 |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 1,250 IU | 10 mg | 10 mg | 548 days | 126 |
| Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial 2017 · LNS-Zn10 · Children aged 9–10 months at enrollment, followed to 18 months; children with severe anemia, severe wasting, or illness requiring hospital referral were excluded. | 400 mcg | 10 mg | 6 mg | 274 days | 79 |
| Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial 2017 · LNS-Zn5 · Children aged 9–10 months at enrollment, followed to 18 months; children with severe anemia, severe wasting, or illness requiring hospital referral were excluded. | 400 mcg | 5 mg | 6 mg | 274 days | 75 |