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Arginine and Glutamine: study protocols

15 study groups took Arginine together with Glutamine. These are the doses the studies gave. They are not a recommendation.

Arginine: what the research found →

Dose per serving from research: Arginine

15 study groups in 15 studies say how much Arginine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 g to 25 g, 80% of 15 study groups.

Daily doseStudy groups
5 g or less
1
5 g to 10 g
2
10 g to 25 g
12

Dose per serving from research: Glutamine

15 study groups in 15 studies say how much Glutamine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 g to 25 g, 73% of 15 study groups.

Daily doseStudy groups
5 g to 10 g
3
10 g to 25 g
11
over 25 g
1

Commonly used together

14 of 15 study groups took Arginine and Glutamine with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
HMB
10

15 study groups

Study
Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial
2014 · Arginine, glutamine and β-hydroxy-β-methylbutyrate supplementation · Adults aged 28–86 with type 1 or type 2 diabetes and at least one non-infected University of Texas grade 1A diabetic foot ulcer
14 g14 g16 weeks129
Effect of Preoperative Administration of Oral Arginine and Glutamine in Patients with Enterocutaneous Fistula Submitted to Definitive Surgery: a Prospective Randomized Trial
2020 · experimental group · Patients with enterocutaneous fistula undergoing definitive surgery
4.5 g10 g7 days20
Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study
2000 · HMB/Arg/Gln · HIV-infected adults with AIDS-associated wasting and at least 5% documented weight loss in the previous 3 months
14 g14 g8 weeks22
Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine
2002 · HMB/Arg/Gln · Patients with advanced solid tumors and at least 5% weight loss
14 g14 g24 weeks18
Effect of administration of β-hydroxy-β-methyl butyrate-enriched formula after liver transplantation: A pilot randomized controlled trial
2020 · HMB group · Adults who underwent living donor liver transplantation
14 g14 g30 days12
Effect of a Food for Special Medical Purposes for Muscle Recovery, Consisting of Arginine, Glutamine and Beta-Hydroxy-Beta-Methylbutyrate on Body Composition and Skin Health in Overweight and Obese Class I Sedentary Postmenopausal Women
2021 · supplement group · Women aged 45–65 who were sedentary, postmenopausal, and overweight or obese class I (BMI 25–35 kg/m²)
7.4 g7.4 g4 weeks10
Effects of 6-month supplementation with β-hydroxy-β-methylbutyrate, glutamine and arginine on vascular endothelial function of older adults
2016 · supplement group · Community-dwelling men and women aged 65–87
14 g14 g24 weeks—
Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults
2019 · amino acid supplement group · Community-dwelling, ambulatory men and women aged 65 years and older in generally good health
14 g14 g26 weeks—
Supplemental Protein and a Multinutrient Beverage Speed Wound Healing after Acute Sleep Restriction in Healthy Adults
2022 · NUT · Generally healthy young adults aged 18–approximately 20 years (18 males and 2 females), after acute sleep restriction
20 g30 g7 days—
The effects of preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine on inflammatory and hematological markers of patients with heart surgery: a randomized controlled trial
2022 · Heallagen® group · Adults aged 18–70 undergoing cardiac surgery
7 g7 g30 days30
Evaluation of the recovery after heart surgery following preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, L-arginine, and L-glutamine: a double-blind randomized placebo-controlled clinical trial
2022 · Gln/Arg/HMB · Adults aged 18–70 undergoing cardiac surgery
14 g14 g30 days30
Effect of a specialized amino acid mixture on human collagen deposition
2002 · Specialized amino acid mixture · Healthy, nonsmoking adults aged 70 years or older
14 g14 g2 weeks18
Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial
2025 · HMB supplementation · Patients aged 65 years or older scheduled for elective cardiac surgery
14 g14 g2 weeks—
The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass
2011 · experimental group · Adults with morbid obesity undergoing laparoscopic gastric bypass; age and sex range not reported
14 g14 g8 weeks14
Multinutrient Supplementation Increases Collagen Synthesis during Early Wound Repair in a Randomized Controlled Trial in Patients with Inguinal Hernia
2020 · multinutrient group · Men scheduled for Lichtenstein inguinal hernia repair; mean age 55.2 years, with inguinal hernia disease
14 g14 g4 weeks10
Arginine and Glutamine: study protocols | supp.fit