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Arginine, Glutamine and HMB: study protocols

10 study groups took Arginine together with Glutamine and HMB. These are the doses the studies gave. They are not a recommendation.

Arginine: what the research found →

Dose per serving from research: Arginine

10 study groups in 10 studies say how much Arginine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 g to 25 g, 80% of 10 study groups.

Daily doseStudy groups
5 g to 10 g
2
10 g to 25 g
8

Dose per serving from research: Glutamine

10 study groups in 10 studies say how much Glutamine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 g to 25 g, 80% of 10 study groups.

Daily doseStudy groups
5 g to 10 g
2
10 g to 25 g
8

Dose per serving from research: HMB

10 study groups in 10 studies say how much HMB participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 g to 5 g, 70% of 10 study groups.

Daily doseStudy groups
1 g to 2.5 g
3
2.5 g to 5 g
7

Commonly used together

None of these 10 study groups took Arginine, Glutamine and HMB with anything else.

10 study groups

Study
Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study
2000 · HMB/Arg/Gln · HIV-infected adults with AIDS-associated wasting and at least 5% documented weight loss in the previous 3 months
14 g14 g3 g8 weeks22
Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine
2002 · HMB/Arg/Gln · Patients with advanced solid tumors and at least 5% weight loss
14 g14 g3 g24 weeks18
Effect of administration of β-hydroxy-β-methyl butyrate-enriched formula after liver transplantation: A pilot randomized controlled trial
2020 · HMB group · Adults who underwent living donor liver transplantation
14 g14 g3 g30 days12
Effect of a Food for Special Medical Purposes for Muscle Recovery, Consisting of Arginine, Glutamine and Beta-Hydroxy-Beta-Methylbutyrate on Body Composition and Skin Health in Overweight and Obese Class I Sedentary Postmenopausal Women
2021 · supplement group · Women aged 45–65 who were sedentary, postmenopausal, and overweight or obese class I (BMI 25–35 kg/m²)
7.4 g7.4 g1.3 g4 weeks10
Effects of 6-month supplementation with β-hydroxy-β-methylbutyrate, glutamine and arginine on vascular endothelial function of older adults
2016 · supplement group · Community-dwelling men and women aged 65–87
14 g14 g3 g24 weeks—
Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults
2019 · amino acid supplement group · Community-dwelling, ambulatory men and women aged 65 years and older in generally good health
14 g14 g3 g26 weeks—
The effects of preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine on inflammatory and hematological markers of patients with heart surgery: a randomized controlled trial
2022 · Heallagen® group · Adults aged 18–70 undergoing cardiac surgery
7 g7 g1.5 g30 days30
Evaluation of the recovery after heart surgery following preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, L-arginine, and L-glutamine: a double-blind randomized placebo-controlled clinical trial
2022 · Gln/Arg/HMB · Adults aged 18–70 undergoing cardiac surgery
14 g14 g3 g30 days30
Effect of a specialized amino acid mixture on human collagen deposition
2002 · Specialized amino acid mixture · Healthy, nonsmoking adults aged 70 years or older
14 g14 g3 g2 weeks18
Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial
2025 · HMB supplementation · Patients aged 65 years or older scheduled for elective cardiac surgery
14 g14 g2.4 g2 weeks—
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