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Zinc and Folic Acid: study protocols

16 study groups took Zinc together with Folic Acid. These are the doses the studies gave. They are not a recommendation.

Zinc: what the research found →

Dose per serving from research: Zinc

16 study groups in 14 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 31% of 16 study groups.

Daily doseStudy groups
2.5 mg to 5 mg
3
5 mg to 10 mg
4
10 mg to 25 mg
5
25 mg to 50 mg
4

Dose per serving from research: Folic Acid

15 study groups in 13 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mcg to 250 mcg, 47% of 15 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
7
250 mcg to 500 mcg
6
over 500 mcg
1

Commonly used together

16 of 16 study groups took Zinc and Folic Acid with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Iron
14
Vitamin A
10
Vitamin B12
6
Vitamin C
6
Vitamin B6
4
Vitamin D
4
Copper
3
Iodine
3
Riboflavin
3
Vitamin E
3

16 study groups

Study
Effect of prenatal zinc supplementation on birthweight
2009 · Iron-zinc group · Pregnant women recruited by 16 weeks’ gestation in Ghana; age range 16–44 years; no stated diagnosed condition, with women taking other zinc supplements or with severe anaemia excluded.
20 mg200 mcg—299
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Folic acid + iron + zinc · Pregnant women in rural Nepal
30 mg400 mcg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
30 mg400 mcg——
Maternal zinc supplementation and growth in Peruvian infants
2008 · zinc group · Pregnant women enrolled at 10–24 weeks of gestation; low-risk pregnancy
15 mg250 mcg—273
Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5- to 11-mo old
2006 · iron+folic acid+zinc (FeFA+Zn) · Children aged 5–11 months at the start of supplementation, nutritionally at risk, in Pemba, Zanzibar
10 mg50 mcg1 year—
Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants
2010 · zinc · Pregnant women in a periurban slum of Lima, Peru
15 mg250 mcg——
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
10 mg400 mcg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
12 mg600 mcg165 days749
Short-term daily or weekly administration of micronutrient Sprinkles has high compliance and does not cause iron overload in Chinese schoolchildren: a cluster-randomised trial
2006 · daily group · Children aged 3–6 years in a kindergarten in northern China
5 mg150 mcg13 weeks—
Community-level micronutrient fortification of school lunch meals improved vitamin A, folate, and iron status of schoolchildren in Himalayan villages of India
2010 · multiple micronutrients (treatment group) · Schoolchildren aged 6–10 years in Himalayan villages of India
4.2 mg225 mcg240 days—