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Zinc, Folic Acid and Iron: study protocols

21 study groups took Zinc together with Folic Acid and Iron. These are the doses the studies gave. They are not a recommendation.

Zinc: what the research found →

Dose per serving from research: Zinc

21 study groups in 17 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 38% of 21 study groups.

Daily doseStudy groups
2.5 mg to 5 mg
4
5 mg to 10 mg
4
10 mg to 25 mg
5
25 mg to 50 mg
8

Dose per serving from research: Folic Acid

20 study groups in 16 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 45% of 20 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
8
250 mcg to 500 mcg
9
500 mcg to 1 mg
2

Dose per serving from research: Iron

19 study groups in 16 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 37% of 19 study groups.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
5
25 mg to 50 mg
5
50 mg to 100 mg
7

Commonly used together

15 of 21 study groups took Zinc, Folic Acid and Iron with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin A
13
Vitamin C
9
Vitamin D
7
Copper
6
Iodine
6
Vitamin B12
6
Vitamin E
6
Selenium
5
Riboflavin
4
Vitamin B6
4

21 study groups

Study
Effect of prenatal zinc supplementation on birthweight
2009 · Iron-zinc group · Pregnant women recruited by 16 weeks’ gestation in Ghana; age range 16–44 years; no stated diagnosed condition, with women taking other zinc supplements or with severe anaemia excluded.
20 mg200 mcg20 mg—299
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Folic acid + iron + zinc · Pregnant women in rural Nepal
30 mg400 mcg60 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
30 mg400 mcg———
Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5- to 11-mo old
2006 · iron+folic acid+zinc (FeFA+Zn) · Children aged 5–11 months at the start of supplementation, nutritionally at risk, in Pemba, Zanzibar
10 mg50 mcg12.5 mg1 year—
Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants
2010 · zinc · Pregnant women in a periurban slum of Lima, Peru
15 mg250 mcg60 mg——
Zinc plus beta-carotene supplementation of pregnant women is superior to beta-carotene supplementation alone in improving vitamin A status in both mothers and infants
2004 · zinc · Pregnant women; age and specific condition not stated
30 mg400 mcg30 mg——
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
10 mg400 mcg12 mg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
12 mg600 mcg27 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
12 mg600 mcg27 mg—176
mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia
30 mg400 mcg60 mg184 days75