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Vitamin K, Calcium and Vitamin D: study protocols

18 study groups took Vitamin K together with Calcium and Vitamin D. These are the doses the studies gave. They are not a recommendation.

Vitamin K: what the research found →

Dose per serving from research: Vitamin K

18 study groups in 15 studies say how much Vitamin K participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mcg to 250 mcg, 28% of 18 study groups.

Daily doseStudy groups
10 mcg or less
1
10 mcg to 25 mcg
2
25 mcg to 50 mcg
0
50 mcg to 100 mcg
2
100 mcg to 250 mcg
5
250 mcg to 500 mcg
3
500 mcg to 1 mg
3
1 mg to 2.5 mg
0
2.5 mg to 5 mg
1
5 mg to 10 mg
0
10 mg to 25 mg
0
over 25 mg
1

Dose per serving from research: Calcium

17 study groups in 14 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mg to 1 g, 82% of 17 study groups.

Daily doseStudy groups
250 mg to 500 mg
2
500 mg to 1 g
14
1 g to 2.5 g
1

Dose per serving from research: Vitamin D

12 study groups in 9 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mcg to 10 mcg, 58% of 12 study groups.

Daily doseStudy groups
5 mcg or less
1
5 mcg to 10 mcg
7
10 mcg to 25 mcg
2
25 mcg to 50 mcg
2

Commonly used together

2 of 18 study groups took Vitamin K, Calcium and Vitamin D with something else, but nothing that 3 or more different studies gave.

18 study groups

Study
Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
2008 · vitamin K group · Postmenopausal women with osteopenia; mean age 59 years, range 40–82
5 mg1.5 g800 IU4 years217
Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old
2011 · treatment group (vitamin K) · Postmenopausal Korean women over 60 years old
45 mg630 mg400 IU26 weeks40
Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II
2011 · CaDK1 group · Postmenopausal women
100 mcg800 mg10 mcg1 year26
Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II
2011 · CaDK2 group · Postmenopausal women
100 mcg800 mg10 mcg1 year24
Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women
2007 · combined vitamins K1 and D3 plus calcium · Healthy, nonosteoporotic Scottish women aged 60 years or older
200 mcg1 g10 mcg2 years—
The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial
2021 · vitamin K2 (MK-7) group · Postmenopausal women with osteopenia
375 mcg800 mg38 mcg1096 days—
Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study
2013 · geniVida bone blend (GBB) · Healthy postmenopausal women aged 45–55 years, 1–3 years since their last spontaneous menstrual bleeding
150 mcg500 mg800 IU26 weeks31
Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age
2003 · MDK group · Healthy postmenopausal women aged 50–60 years
1 mg——3 years—
Effect of phylloquinone (vitamin K1) supplementation for 12 months on the indices of vitamin K status and bone health in adult patients with Crohn's disease
2014 · 1000 μg vitamin K/d plus calcium and vitamin D3 group (main RCT) · Adults with Crohn's disease, currently in remission
1 mg500 mg10 mcg1 year43
The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD
2016 · vitamin D, vitamin K and calcium supplements · Overweight patients with type 2 diabetes and CHD; age and sex not specified
180 mcg1 g10 mcg12 weeks33
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial
2016 · HD/HK · Postmenopausal women aged 50–65 years
23.1 mcg1 g16.3 mcg12 weeks31
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial
2016 · HD/LK · Postmenopausal women aged 50–65 years
1.37 mcg1 g15 mcg12 weeks31
The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
2016 · vitamin D-K-calcium co-supplementation group · Vitamin D-deficient women aged 18–40 years with polycystic ovary syndrome
180 mcg1 g400 IU8 weeks30
Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention trial
2016 · LD/HK · Postmenopausal women aged 50–65 years
23.1 mcg1 g3.86 mcg12 weeks30
The Effects of Calcium, Vitamins D and K co-Supplementation on Markers of Insulin Metabolism and Lipid Profiles in Vitamin D-Deficient Women with Polycystic Ovary Syndrome
2017 · calcium, vitamin D and vitamin K group · Women aged 18–40 years with vitamin D deficiency and polycystic ovary syndrome
180 mcg1 g400 IU8 weeks28
Effect of calcium, vitamins K1 and D3 on bone in galactosemia
2006 · calcium, vitamins K1 and D3 supplementation · Children aged 3–17 years with classical galactosemia
1 mg750 mg10 mcg2 years—
Effect of vitamin K supplementation on insulin resistance in older men and women
2008 · Vitamin K–treated group · Men and postmenopausal women aged 60–80 without diabetes
500 mcg600 mg10 mcg3 years—
Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial
2021 · MK-7 group · Postmenopausal women; the abstract describes them as healthy
375 mcg800 mg38 mcg1 year—
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