Vitamin B12, Vitamin E, Folic Acid and Vitamin C: study protocols
9 study groups took Vitamin B12 together with Vitamin E, Folic Acid and Vitamin C. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin B12
9 study groups in 7 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 67% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mcg to 2.5 mcg | 1 |
| 2.5 mcg to 5 mcg | 6 |
| 5 mcg to 10 mcg | 0 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
Dose per serving from research: Vitamin E
9 study groups in 7 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 44% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 2 |
| 10 mg to 25 mg | 3 |
| 25 mg to 50 mg | 4 |
Dose per serving from research: Folic Acid
9 study groups in 7 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg and 500 mcg to 1 mg, 44% of 9 study groups each.
| Daily dose | Study groups |
|---|---|
| 100 mcg or less | 1 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 4 |
| 500 mcg to 1 mg | 4 |
Dose per serving from research: Vitamin C
8 study groups in 6 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg, 63% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 5 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 2 |
Commonly used together
9 of 9 study groups took Vitamin B12, Vitamin E, Folic Acid and Vitamin C with something else. Shown: what 3 or more different studies gave. The 10 most common of 11.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin B6 | 8 |
| Selenium | 6 |
| Vitamin A | 6 |
| Copper | 5 |
| Vitamin D | 5 |
| Zinc | 5 |
| Iodine | 4 |
| Iron | 4 |
| Riboflavin | 4 |
| Thiamine | 4 |
9 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 2.6 mcg | 10 mg | 400 mcg | 100 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 50 mcg | 30 mg | 800 mcg | 500 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women | 50 mcg | 30 mg | 800 mcg | 500 mg | — | — |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 2.6 mcg | 15 mg | 600 mcg | 85 mg | 165 days | 749 |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active group (RCT1, RCT2 and RCT3) · Men and women aged 50 years or older with mild or mild-to-moderate Alzheimer's disease; RCT3 participants were on stable approved Alzheimer's medication, while RCT1 and RCT2 participants were drug-free for Alzheimer's medication. | 3 mcg | 40 mg | 400 mcg | 80 mg | 24 weeks | 501 |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active product during open-label extension (OLE) · Men and women aged 50 years or older with mild Alzheimer's disease who completed RCT2. | 3 mcg | 40 mg | 400 mcg | 80 mg | 24 weeks | 201 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 2.6 mcg | 15 mg | 600 mcg | 85 mg | — | 176 |
| Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial 2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years | 2.4 mcg | 14 mg | 40 mcg | 50 mg | 26 weeks | 104 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 2.6 mcg | 10 mg | 400 mcg | — | 12 weeks | 105 |