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All Vitamin B12 study protocols

Vitamin B12 and Vitamin C: study protocols

10 study groups took Vitamin B12 together with Vitamin C. These are the doses the studies gave. They are not a recommendation.

Vitamin B12: what the research found →

Dose per serving from research: Vitamin B12

10 study groups in 8 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 60% of 10 study groups.

Daily doseStudy groups
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
6
5 mcg to 10 mcg
1
10 mcg to 25 mcg
0
25 mcg to 50 mcg
2

Dose per serving from research: Vitamin C

9 study groups in 7 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 56% of 9 study groups.

Daily doseStudy groups
25 mg to 50 mg
2
50 mg to 100 mg
5
100 mg to 250 mg
0
250 mg to 500 mg
2

Commonly used together

10 of 10 study groups took Vitamin B12 and Vitamin C with something else. Shown: what 3 or more different studies gave. The 10 most common of 13.

What was given together, not what works together.

Taken withStudy groups
Folic Acid
10
Vitamin B6
9
Vitamin E
9
Selenium
6
Vitamin A
6
Copper
5
Vitamin D
5
Zinc
5
Iodine
4
Iron
4

10 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
2.6 mcg100 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women
50 mcg500 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women
50 mcg500 mg——
Low-dose B vitamins supplementation ameliorates cardiovascular risk: a double-blind randomized controlled trial in healthy Chinese elderly
2015 · treatment group · Healthy adults aged 60–74 years
10 mcg50 mg1 year—
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
2.6 mcg85 mg165 days749
Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease
2015 · Active group (RCT1, RCT2 and RCT3) · Men and women aged 50 years or older with mild or mild-to-moderate Alzheimer's disease; RCT3 participants were on stable approved Alzheimer's medication, while RCT1 and RCT2 participants were drug-free for Alzheimer's medication.
3 mcg80 mg24 weeks501
Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease
2015 · Active product during open-label extension (OLE) · Men and women aged 50 years or older with mild Alzheimer's disease who completed RCT2.
3 mcg80 mg24 weeks201
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
2.6 mcg85 mg—176
Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial
2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years
2.4 mcg50 mg26 weeks104
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
2.6 mcg—12 weeks105