Vitamin B12 and Thiamine: study protocols
9 study groups took Vitamin B12 together with Thiamine. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin B12
9 study groups in 7 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mcg to 2.5 mcg and 2.5 mcg to 5 mcg and 25 mcg to 50 mcg and 1 mg to 2.5 mg, 22% of 9 study groups each.
| Daily dose | Study groups |
|---|---|
| 1 mcg or less | 1 |
| 1 mcg to 2.5 mcg | 2 |
| 2.5 mcg to 5 mcg | 2 |
| 5 mcg to 10 mcg | 0 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
| 50 mcg to 100 mcg | 0 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 0 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 2 |
Dose per serving from research: Thiamine
9 study groups in 7 studies say how much Thiamine participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 44% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mcg or less | 1 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 4 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 0 |
| 50 mg to 100 mg | 1 |
| 100 mg to 250 mg | 0 |
| over 250 mg | 1 |
Commonly used together
9 of 9 study groups took Vitamin B12 and Thiamine with something else. Shown: what 3 or more different studies gave. The 10 most common of 11.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin B6 | 9 |
| Riboflavin | 7 |
| Folic Acid | 5 |
| Iron | 5 |
| Vitamin E | 5 |
| Vitamin A | 4 |
| Vitamin C | 4 |
| Vitamin D | 4 |
| Copper | 3 |
| Niacin | 3 |
9 study groups
| Study | ||||
|---|---|---|---|---|
| Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study 2009 · Group DB (combination therapy) · Adults with acute lumbago | 2 mg | 100 mg | 7 days | 187 |
| A Randomized Control Trial of Dexketoprofen/Vitamin B (Thiamine, Pyridoxine and Cyanocobalamin) Fixed-Dose Combination in Post-Traumatic Grade I-II Cervical Sprains 2024 · Dexketoprofen/vitamin B · Adults aged 18 years or older, both sexes, with grade I–II post-traumatic cervical sprain and acute pain | 1.5 mg | 300 mg | 7 days | 83 |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 2.6 mcg | 1.6 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 50 mcg | 20 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women | 50 mcg | 20 mg | — | — |
| Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial 2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies | 0.9 mcg | 500 mcg | 36 weeks | 130 |
| Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial 2016 · Fortified cereal, morning · Females aged 16–19 years who regularly skipped breakfast and had low riboflavin status and haemoglobin; no diagnosed illness | 1.45 mcg | 1.21 mg | 12 weeks | 18 |
| Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial 2016 · Fortified cereal, evening · Females aged 16–19 years who regularly skipped breakfast and had low riboflavin status and haemoglobin; no diagnosed illness | 1.45 mcg | 1.21 mg | 12 weeks | 16 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 2.6 mcg | 1.4 mg | 12 weeks | 105 |