Vitamin B12, Riboflavin, Vitamin D and Vitamin B6: study protocols
6 study groups took Vitamin B12 together with Riboflavin, Vitamin D and Vitamin B6. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin B12
6 study groups in 5 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mcg to 2.5 mcg and 2.5 mcg to 5 mcg and 5 mcg to 10 mcg, 33% of 6 study groups each.
| Daily dose | Study groups |
|---|---|
| 1 mcg to 2.5 mcg | 2 |
| 2.5 mcg to 5 mcg | 2 |
| 5 mcg to 10 mcg | 2 |
Dose per serving from research: Riboflavin
6 study groups in 5 studies say how much Riboflavin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 83% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 5 |
| 2.5 mg to 5 mg | 1 |
Dose per serving from research: Vitamin D
5 study groups in 4 studies say how much Vitamin D participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mcg to 10 mcg, 60% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mcg to 5 mcg | 2 |
| 5 mcg to 10 mcg | 3 |
Dose per serving from research: Vitamin B6
6 study groups in 5 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 67% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 4 |
| 2.5 mg to 5 mg | 1 |
| 5 mg to 10 mg | 1 |
Commonly used together
6 of 6 study groups took Vitamin B12, Riboflavin, Vitamin D and Vitamin B6 with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Iron | 5 |
| Folic Acid | 4 |
| Thiamine | 4 |
| Zinc | 3 |
6 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 2.6 mcg | 1.8 mg | 10 mcg | 2.2 mg | — | — |
| A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status 2022 · B-vitamin treatment · Community-dwelling adults aged 50 years or older; men and women; no specific diagnosed condition, and not currently taking B-vitamin supplements at screening | 10 mcg | 5 mg | 10 mcg | 10 mg | 2 years | 103 |
| Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial 2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception | 5.2 mcg | 1.8 mg | 10 mcg | 2.6 mg | — | 870 |
| Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial 2016 · Fortified cereal, morning · Females aged 16–19 years who regularly skipped breakfast and had low riboflavin status and haemoglobin; no diagnosed illness | 1.45 mcg | 1.71 mg | 4.15 mcg | 1.74 mg | 12 weeks | 18 |
| Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: a randomised controlled trial 2016 · Fortified cereal, evening · Females aged 16–19 years who regularly skipped breakfast and had low riboflavin status and haemoglobin; no diagnosed illness | 1.45 mcg | 1.71 mg | 4.15 mcg | 1.74 mg | 12 weeks | 16 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 2.6 mcg | 1.4 mg | — | 1.9 mg | 12 weeks | 105 |