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Vitamin B12, Iron, Vitamin A and Folic Acid: study protocols

8 study groups took Vitamin B12 together with Iron, Vitamin A and Folic Acid. These are the doses the studies gave. They are not a recommendation.

Vitamin B12: what the research found →

Dose per serving from research: Vitamin B12

8 study groups in 7 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 50% of 8 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
4
5 mcg to 10 mcg
0
10 mcg to 25 mcg
0
25 mcg to 50 mcg
0
50 mcg to 100 mcg
0
100 mcg to 250 mcg
0
250 mcg to 500 mcg
0
500 mcg to 1 mg
0
1 mg to 2.5 mg
0
2.5 mg to 5 mg
0
5 mg to 10 mg
2

Dose per serving from research: Iron

7 study groups in 6 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 43% of 7 study groups.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
2
25 mg to 50 mg
3

Dose per serving from research: Vitamin A

5 study groups in 5 studies say how much Vitamin A participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 60% of 5 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
2
500 mcg to 1 mg
3

Dose per serving from research: Folic Acid

8 study groups in 7 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 50% of 8 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
2
250 mcg to 500 mcg
4
500 mcg to 1 mg
2

Commonly used together

8 of 8 study groups took Vitamin B12, Iron, Vitamin A and Folic Acid with something else. Shown: what 3 or more different studies gave. The 10 most common of 11.

What was given together, not what works together.

Taken withStudy groups
Zinc
6
Copper
5
Vitamin E
5
Iodine
4
Selenium
4
Vitamin B6
4
Vitamin C
4
Vitamin D
4
Niacin
3
Riboflavin
3

8 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
2.6 mcg—1 mg400 mcg——
Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving
2018 · MMN · Pregnant women enrolled at ≤20 weeks’ gestation in Malawi, followed through 6 months postpartum
5.2 mg20 mg—400 mcg1 year239
Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving
2018 · LNS · Pregnant women enrolled at ≤20 weeks’ gestation in Malawi, followed through 6 months postpartum
5.2 mg20 mg—400 mcg1 year234
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
2.6 mcg27 mg770 mcg600 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
2.6 mcg27 mg770 mcg600 mcg—176
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
0.9 mcg6 mg400 mcg150 mcg36 weeks130
Community-level micronutrient fortification of school lunch meals improved vitamin A, folate, and iron status of schoolchildren in Himalayan villages of India
2010 · multiple micronutrients (treatment group) · Schoolchildren aged 6–10 years in Himalayan villages of India
1.35 mcg10 mg375 mcg225 mcg240 days—
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
2.6 mcg30 mg—400 mcg12 weeks105