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Vitamin B12, Iron and Folic Acid: study protocols

12 study groups took Vitamin B12 together with Iron and Folic Acid. These are the doses the studies gave. They are not a recommendation.

Vitamin B12: what the research found →

Dose per serving from research: Vitamin B12

12 study groups in 11 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 33% of 12 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
4
5 mcg to 10 mcg
1
10 mcg to 25 mcg
0
25 mcg to 50 mcg
1
50 mcg to 100 mcg
0
100 mcg to 250 mcg
0
250 mcg to 500 mcg
0
500 mcg to 1 mg
1
1 mg to 2.5 mg
1
2.5 mg to 5 mg
0
5 mg to 10 mg
2

Dose per serving from research: Iron

9 study groups in 8 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg and 25 mg to 50 mg, 33% of 9 study groups each.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
3
25 mg to 50 mg
3
over 50 mg
1

Dose per serving from research: Folic Acid

10 study groups in 9 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 60% of 10 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
2
250 mcg to 500 mcg
6
500 mcg to 1 mg
2

Commonly used together

9 of 12 study groups took Vitamin B12, Iron and Folic Acid with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.

What was given together, not what works together.

Taken withStudy groups
Vitamin A
8
Zinc
7
Copper
5
Iodine
5
Vitamin B6
5
Vitamin D
5
Vitamin E
5
Riboflavin
4
Selenium
4
Vitamin C
4

12 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
2.6 mcg—400 mcg——
Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving
2018 · MMN · Pregnant women enrolled at ≤20 weeks’ gestation in Malawi, followed through 6 months postpartum
5.2 mg20 mg400 mcg1 year239
Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving
2018 · LNS · Pregnant women enrolled at ≤20 weeks’ gestation in Malawi, followed through 6 months postpartum
5.2 mg20 mg400 mcg1 year234
Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status
2014 · Vitamin B-12 group · Pregnant women in Bangalore, India, enrolled before 14 weeks of gestation; followed through early lactation
50 mcg———183
Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial
2022 · Group B (oral vitamin B12) · Children aged 2 months–18 years with nutritional macrocytic-megaloblastic anemia
1.5 mg——90 days—
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
5.2 mcg12 mg400 mcg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
2.6 mcg27 mg600 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
2.6 mcg27 mg600 mcg—176
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
0.9 mcg6 mg150 mcg36 weeks130
Community-level micronutrient fortification of school lunch meals improved vitamin A, folate, and iron status of schoolchildren in Himalayan villages of India
2010 · multiple micronutrients (treatment group) · Schoolchildren aged 6–10 years in Himalayan villages of India
1.35 mcg10 mg225 mcg240 days—