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Vitamin B12, Folic Acid, Zinc, Vitamin A and Vitamin E: study protocols

6 study groups took Vitamin B12 together with Folic Acid, Zinc, Vitamin A and Vitamin E. These are the doses the studies gave. They are not a recommendation.

Vitamin B12: what the research found →

Dose per serving from research: Vitamin B12

6 study groups in 6 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 67% of 6 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
4

Dose per serving from research: Folic Acid

6 study groups in 6 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg and 500 mcg to 1 mg, 33% of 6 study groups each.

Daily doseStudy groups
50 mcg or less
1
50 mcg to 100 mcg
0
100 mcg to 250 mcg
1
250 mcg to 500 mcg
2
500 mcg to 1 mg
2

Dose per serving from research: Zinc

6 study groups in 6 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 50% of 6 study groups.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
3
25 mg to 50 mg
1

Dose per serving from research: Vitamin A

5 study groups in 5 studies say how much Vitamin A participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 80% of 5 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
1
500 mcg to 1 mg
4

Dose per serving from research: Vitamin E

6 study groups in 6 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 50% of 6 study groups.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
2
10 mg to 25 mg
3

Commonly used together

6 of 6 study groups took Vitamin B12, Folic Acid, Zinc, Vitamin A and Vitamin E with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Copper
6
Iodine
5
Iron
5
Selenium
5
Vitamin B6
5
Vitamin C
5
Vitamin D
5
Niacin
4
Riboflavin
3
Thiamine
3

6 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
2.6 mcg400 mcg30 mg1 mg10 mg——
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
2.6 mcg600 mcg12 mg770 mcg15 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
2.6 mcg600 mcg12 mg770 mcg15 mg—176
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
0.9 mcg150 mcg10 mg400 mcg5 mg36 weeks130
Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial
2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years
2.4 mcg40 mcg10 mg800 mcg14 mg26 weeks104
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
2.6 mcg400 mcg15 mg—10 mg12 weeks105