Vitamin B12, Folic Acid, Vitamin C, Vitamin B6 and Vitamin E: study protocols
8 study groups took Vitamin B12 together with Folic Acid, Vitamin C, Vitamin B6 and Vitamin E. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin B12
8 study groups in 6 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 63% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mcg to 2.5 mcg | 1 |
| 2.5 mcg to 5 mcg | 5 |
| 5 mcg to 10 mcg | 0 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
Dose per serving from research: Folic Acid
8 study groups in 6 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 50% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg or less | 1 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 4 |
| 500 mcg to 1 mg | 3 |
Dose per serving from research: Vitamin C
7 study groups in 5 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg, 57% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 4 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 2 |
Dose per serving from research: Vitamin B6
8 study groups in 6 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 50% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mcg to 1 mg | 2 |
| 1 mg to 2.5 mg | 4 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 2 |
Dose per serving from research: Vitamin E
8 study groups in 6 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 50% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 2 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 4 |
Commonly used together
8 of 8 study groups took Vitamin B12, Folic Acid, Vitamin C, Vitamin B6 and Vitamin E with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Selenium | 5 |
| Vitamin A | 5 |
| Copper | 4 |
| Riboflavin | 4 |
| Thiamine | 4 |
| Vitamin D | 4 |
| Zinc | 4 |
| Iodine | 3 |
| Iron | 3 |
| Niacin | 3 |
8 study groups
| Study | |||||||
|---|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 2.6 mcg | 400 mcg | 100 mg | 2.2 mg | 10 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 50 mcg | 800 mcg | 500 mg | 25 mg | 30 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women | 50 mcg | 800 mcg | 500 mg | 25 mg | 30 mg | — | — |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active group (RCT1, RCT2 and RCT3) · Men and women aged 50 years or older with mild or mild-to-moderate Alzheimer's disease; RCT3 participants were on stable approved Alzheimer's medication, while RCT1 and RCT2 participants were drug-free for Alzheimer's medication. | 3 mcg | 400 mcg | 80 mg | 1 mg | 40 mg | 24 weeks | 501 |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active product during open-label extension (OLE) · Men and women aged 50 years or older with mild Alzheimer's disease who completed RCT2. | 3 mcg | 400 mcg | 80 mg | 1 mg | 40 mg | 24 weeks | 201 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 2.6 mcg | 600 mcg | 85 mg | 1.9 mg | 15 mg | — | 176 |
| Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial 2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years | 2.4 mcg | 40 mcg | 50 mg | 1.2 mg | 14 mg | 26 weeks | 104 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 2.6 mcg | 400 mcg | — | 1.9 mg | 10 mg | 12 weeks | 105 |