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Vitamin B12, Folic Acid, Vitamin C and Vitamin A: study protocols

6 study groups took Vitamin B12 together with Folic Acid, Vitamin C and Vitamin A. These are the doses the studies gave. They are not a recommendation.

Vitamin B12: what the research found →

Dose per serving from research: Vitamin B12

6 study groups in 6 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 67% of 6 study groups.

Daily doseStudy groups
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
4
5 mcg to 10 mcg
0
10 mcg to 25 mcg
0
25 mcg to 50 mcg
1

Dose per serving from research: Folic Acid

6 study groups in 6 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 50% of 6 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
0
250 mcg to 500 mcg
2
500 mcg to 1 mg
3

Dose per serving from research: Vitamin C

5 study groups in 5 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 60% of 5 study groups.

Daily doseStudy groups
50 mg or less
1
50 mg to 100 mg
3
100 mg to 250 mg
0
250 mg to 500 mg
1

Commonly used together

6 of 6 study groups took Vitamin B12, Folic Acid, Vitamin C and Vitamin A with something else. Shown: what 3 or more different studies gave. The 10 most common of 11.

What was given together, not what works together.

Taken withStudy groups
Vitamin E
6
Copper
5
Vitamin B6
5
Vitamin D
5
Zinc
5
Iodine
4
Iron
4
Selenium
4
Niacin
3
Riboflavin
3

6 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
2.6 mcg400 mcg100 mg1 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women
50 mcg800 mcg500 mg5,000 IU——
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
2.6 mcg600 mcg85 mg770 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
2.6 mcg600 mcg85 mg770 mcg—176
Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial
2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years
2.4 mcg40 mcg50 mg800 mcg26 weeks104
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
2.6 mcg400 mcg——12 weeks105