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Vitamin B12, Folic Acid, Vitamin B6 and Vitamin D: study protocols

6 study groups took Vitamin B12 together with Folic Acid, Vitamin B6 and Vitamin D. These are the doses the studies gave. They are not a recommendation.

Vitamin B12: what the research found →

Dose per serving from research: Vitamin B12

6 study groups in 6 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 50% of 6 study groups.

Daily doseStudy groups
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
3
5 mcg to 10 mcg
2

Dose per serving from research: Folic Acid

6 study groups in 6 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 50% of 6 study groups.

Daily doseStudy groups
50 mcg or less
1
50 mcg to 100 mcg
0
100 mcg to 250 mcg
1
250 mcg to 500 mcg
3
500 mcg to 1 mg
1

Dose per serving from research: Vitamin B6

6 study groups in 6 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 67% of 6 study groups.

Daily doseStudy groups
1 mg to 2.5 mg
4
2.5 mg to 5 mg
1
5 mg to 10 mg
1

Commonly used together

6 of 6 study groups took Vitamin B12, Folic Acid, Vitamin B6 and Vitamin D with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Zinc
5
Copper
4
Iodine
4
Iron
4
Riboflavin
4
Vitamin A
4
Vitamin C
4
Vitamin E
4
Niacin
3
Selenium
3

6 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
2.6 mcg400 mcg2.2 mg10 mcg——
A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status
2022 · B-vitamin treatment · Community-dwelling adults aged 50 years or older; men and women; no specific diagnosed condition, and not currently taking B-vitamin supplements at screening
10 mcg200 mcg10 mg10 mcg2 years103
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
5.2 mcg400 mcg2.6 mg10 mcg—870
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
2.6 mcg600 mcg1.9 mg5 mcg—176
Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial
2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years
2.4 mcg40 mcg1.2 mg400 IU26 weeks104
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
2.6 mcg400 mcg1.9 mg—12 weeks105