Vitamin A, Vitamin E and Vitamin C: study protocols
10 study groups took Vitamin A together with Vitamin E and Vitamin C. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin A
5 study groups in 5 studies say how much Vitamin A participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg, 60% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 1 |
| 250 mcg to 500 mcg | 1 |
| 500 mcg to 1 mg | 3 |
Dose per serving from research: Vitamin E
10 study groups in 10 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 40% of 10 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 4 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 2 |
| 50 mg to 100 mg | 1 |
Dose per serving from research: Vitamin C
10 study groups in 10 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 40% of 10 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 2 |
| 500 mg to 1 g | 1 |
Commonly used together
9 of 10 study groups took Vitamin A, Vitamin E and Vitamin C with something else. Shown: what 3 or more different studies gave. The 10 most common of 13.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Copper | 7 |
| Iron | 7 |
| Vitamin B12 | 7 |
| Zinc | 7 |
| Vitamin B6 | 6 |
| Folic Acid | 5 |
| Iodine | 5 |
| Vitamin D | 5 |
| Selenium | 4 |
| Niacin | 3 |
10 study groups
| Study | |||||
|---|---|---|---|---|---|
| Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Colorectal Cancer Study Group of the University of Modena and the Health Care District 16 1993 · Group 1 (vitamins) · Individuals after endoscopic polypectomy; age and sex not reported; adenomas were the condition of interest. | 30,000 IU | 70 mg | 1 g | 548 days | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 1 mg | 10 mg | 100 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 5,000 IU | 30 mg | 500 mg | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 1,250 IU | 6 mg | 35 mg | 548 days | — |
| Supplementation with multivitamins and vitamin A and incidence of malaria among HIV-infected Tanzanian women 2014 · multivitamins with vitamin A · HIV-infected pregnant women in Tanzania | 5,000 IU | 30 mg | 500 mg | 1249 days | — |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 156 mcg | 7.5 mg | 40.2 mg | 1 year | 316 |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 1,250 IU | 6 mg | 35 mg | 548 days | 126 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 770 mcg | 15 mg | 85 mg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 770 mcg | 15 mg | 85 mg | — | 176 |
| Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial 2021 · intervention · Children aged 6–9 years, apparently healthy, in rural Hai Phong City, Vietnam; included undernourished, normal-weight, and overweight/obese children | 400 mcg | 5 mg | 30 mg | 22 weeks | 175 |