Vitamin A, Vitamin C, Iron and Zinc: study protocols
12 study groups took Vitamin A together with Vitamin C, Iron and Zinc. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin A
10 study groups in 9 studies say how much Vitamin A participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 50% of 10 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 2 |
| 250 mcg to 500 mcg | 5 |
| 500 mcg to 1 mg | 3 |
Dose per serving from research: Vitamin C
12 study groups in 11 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 58% of 12 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg or less | 1 |
| 10 mg to 25 mg | 1 |
| 25 mg to 50 mg | 7 |
| 50 mg to 100 mg | 3 |
Dose per serving from research: Iron
11 study groups in 10 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 45% of 11 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 5 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 3 |
Dose per serving from research: Zinc
12 study groups in 11 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mg to 5 mg and 5 mg to 10 mg, 33% of 12 study groups each.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 1 |
| 2.5 mg to 5 mg | 4 |
| 5 mg to 10 mg | 4 |
| 10 mg to 25 mg | 2 |
| over 25 mg | 1 |
Commonly used together
9 of 12 study groups took Vitamin A, Vitamin C, Iron and Zinc with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Copper | 7 |
| Vitamin E | 7 |
| Folic Acid | 6 |
| Vitamin B12 | 6 |
| Iodine | 5 |
| Vitamin B6 | 5 |
| Vitamin D | 5 |
| Selenium | 4 |
| Niacin | 3 |
| Vitamin K | 3 |
12 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana 2021 · iron-MNP group · Children aged 6–35 months living in rural Ghana; children with severe anaemia, severe malnutrition, recent iron supplementation, or chronic disease were excluded. | 400 mcg | 30 mg | 12.5 mg | 5 mg | 150 days | 967 |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 1 mg | 100 mg | — | 30 mg | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 1,250 IU | 35 mg | 10 mg | 10 mg | 548 days | — |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 156 mcg | 40.2 mg | 9.6 mg | 7.8 mg | 1 year | 316 |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 1,250 IU | 35 mg | 10 mg | 10 mg | 548 days | 126 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 770 mcg | 85 mg | 27 mg | 12 mg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 770 mcg | 85 mg | 27 mg | 12 mg | — | 176 |
| Short-term daily or weekly administration of micronutrient Sprinkles has high compliance and does not cause iron overload in Chinese schoolchildren: a cluster-randomised trial 2006 · daily group · Children aged 3–6 years in a kindergarten in northern China | 300 mcg | 50 mg | 30 mg | 5 mg | 13 weeks | — |
| Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti 2007 · Sprinkles-WSB (S-WSB) · Children aged 9–24 months in rural Haiti receiving take-home fortified wheat-soy blend rations | 400 mcg | 30 mg | 12.5 mg | 5 mg | 60 days | 254 |
| Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial 2021 · intervention · Children aged 6–9 years, apparently healthy, in rural Hai Phong City, Vietnam; included undernourished, normal-weight, and overweight/obese children | 400 mcg | 30 mg | 10 mg | 10 mg | 22 weeks | 175 |